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Tiplaxtinin
- PAI 039
Axon 1383
CAS:
393105-53-8
Purity:
99%
- Soluble in DMSO
- MF: C24H16F3NO4
- MW: 439.38
Description
Tiplaxtinin is a small-molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor that blocks the antifibrinolytic activity of PAI-1.
PAI-1 restrains tissue- and urokinase-type plasminogen activators and contributes to thrombosis, fibrosis, metabolic disease and tumor-associated remodeling. Tiplaxtinin is widely used to investigate PAI-1-dependent fibrinolysis and extracellular-matrix biology.
Key Features
- Small-molecule PAI-1 inhibitor
- Reduces PAI-1-mediated inhibition of plasminogen activators
- Promotes analysis of fibrinolytic pathway activity
- Relevant to thrombosis, fibrosis and cancer research
Applications
- PAI-1 biochemical and functional assays
- Fibrinolysis and thrombotic pathway studies
- Fibrosis and extracellular-matrix remodeling research
- Cancer invasion and metabolic-disease models
More Information
| Parent CAS No. | 393105-53-8 |
|---|---|
| Chemical Name | [1-Benzyl-5-(4-trifluoromethoxy-phe nyl)-1H-indol-3-yl]-oxo-acetic acid |
| SMILES | C1(C2C=CC(OC(F)(F)F)=CC=2)C=C2C(C(=O)C(O)=O)=CN(CC3C=CC=CC=3)C2=CC=1 |
| MFCD | MFCD09475615 |
| InChi | InChI=1S/C24H16F3NO4/c25-24(26,27)32-18-9-6-16(7-10-18)17-8-11-21-19(12-17)20(22(29)23(30)31)14-28(21)13-15-4-2-1-3-5-15/h1-12,14H,13H2,(H,30,31) |
| InChiKey | ODXQFEWQSHNQNI-UHFFFAOYSA-N |
| CID | 6450819 |
| Short Description | PAI-1 inhibitor |
References
- JK Hennan et al. Evaluation of PAI-039 [{1-benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indol-3-yl}(oxo)acetic acid], a novel plasminogen activator inhibitor-1 inhibitor, in a canine model of coronary artery thrombosis. J. Ph. Exp. Ther. 2005, 314(2), 710-6.
- H Elokdah et al. Tiplaxtinin, a Novel, Orally Efficacious Inhibitor of Plasminogen Activator Inhibitor-1: Design, Synthesis, and Preclinical Characterization. J. Med. Chem. 2004, 47, 3491-3494.
- JK Hennan et al. Effect of Tiplaxtinin (PAI-039), an orally bioavailable PAI-1 antagonist, in a rat model of thrombosis. J. Throm. Haem. 2008, 6(9), 1558-1564.
- MP Krause et al. Inhibition of Plasminogen Activator Inhibitor-1 Restores Skeletal Muscle Regeneration in Untreated Type 1 Diabetic Mice. Diabetes, 2011, 60(7), 1964-1972.
- List of publications using Tiplaxtinin (Axon 1383) purchased from Axon Medchem
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