List of publications using CHIR99021 (Axon 1386) purchased from Axon Medchem

(Total 1002 publication citations listed from 2009 up to December 2023)
 

2023 (127 citations)


Almeida, C. F., Robriquet, F., Vetter, T. A., Huang, N., Neinast, R., Hernandez-Rosario, L., ... & Wein, N. (2023). Promising AAV. U7snRNAs vectors targeting DMPK improve DM1 hallmarks in patient-derived cell lines. Frontiers in Cell and Developmental Biology11, 1181040.
https://www.frontiersin.org/articles/10.3389/fcell.2023.1181040/full

Higashitani, Y., & Horie, K. (2023). Long-read sequence analysis of MMEJ-mediated CRISPR genome editing reveals complex on-target vector insertions that may escape standard PCR-based quality control. bioRxiv, 2023-03.
https://www.biorxiv.org/content/10.1101/2023.03.03.531065.abstract
* 2i: PD0325901 and CHIR99021 from Axon Medchem

Zhou, J., Cui, B., Wang, X., Wang, H., Zheng, J., Guo, F., ... & Liang, P. (2023). Overexpression of KCNJ2 enhances maturation of human-induced pluripotent stem cell-derived cardiomyocytes. Stem Cell Research & Therapy14(1), 92.
https://link.springer.com/article/10.1186/s13287-023-03312-9

Ugur, E., de la Porte, A., Qin, W., Bultmann, S., Ivanova, A., Drukker, M., ... & Leonhardt, H. (2023). Comprehensive chromatin proteomics resolves functional phases of pluripotency and identifies changes in regulatory components. Nucleic Acids Research51(6), 2671-2690.
https://academic.oup.com/nar/article-pdf/51/6/2671/49761391/gkad058.pdf
* 2i : PD0325901 and CHIR99021 from Axon Medchem

Mizuno, K., Ohnishi, H., Yoshimatsu, M., Zhao, C., Hayashi, Y., Kuwata, F., ... & Omori, K. (2023). Laryngeal Cartilage Regeneration of Nude Rats by Transplantation of Mesenchymal Stem Cells Derived from Human-Induced Pluripotent Stem Cells. Cell Transplantation32, 09636897231178460.
https://journals.sagepub.com/doi/full/10.1177/09636897231178460

Ying, H., Guo, W., Tang, X., Pan, J., Yu, P., Fan, H., ... & Liang, P. (2023). Colchicine attenuates the electrical remodeling of post-operative atrial fibrillation through inhibited expression of immune-related hub genes and stabilization of microtubules. International Journal of Biological Sciences19(9), 2934.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266076/

Sieliwonczyk, E., Alaerts, M., Simons, E., Snyders, D., Nijak, A., Vandendriessche, B., ... & Loeys, B. (2023). Clinical and functional characterisation of a recurrent KCNQ1 variant in the Belgian population. Orphanet Journal of Rare Diseases18(1), 1-12.
https://ojrd.biomedcentral.com/articles/10.1186/s13023-023-02618-4

Zorzan, I., Betto, R. M., Rossignoli, G., Arboit, M., Drusin, A., Corridori, C., ... & Martello, G. (2023). Chemical conversion of human conventional PSCs to TSCs following transient naive gene activation. EMBO reports24(4), e55235.
https://www.embopress.org/doi/full/10.15252/embr.202255235
* PD0325901, XAV939, GO6983, Y27632, CHIR99021, A83-01 and SB431542 from Axon Medchem

de Jong, M. A., Adegeest, E., Bérenger-Currias, N. M., Mircea, M., Merks, R. M., & Semrau, S. (2023). A combination of convergent extension and differential adhesion explains the shapes of elongating gastruloids. bioRxiv, 2023-05.
https://www.biorxiv.org/content/10.1101/2023.05.24.541949.abstract

Capinha, L., Zhang, Y., Holzer, A. K., Ückert, A. K., Zana, M., Carta, G., ... & Jennings, P. (2023). Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models. Archives of Toxicology97(2), 523-545.
https://link.springer.com/article/10.1007/s00204-022-03436-6

Delás, M. J., Kalaitzis, C. M., Fawzi, T., Demuth, M., Zhang, I., Stuart, H. T., ... & Briscoe, J. (2023). Developmental cell fate choice in neural tube progenitors employs two distinct cis-regulatory strategies. Developmental Cell58(1), 3-17.
https://www.sciencedirect.com/science/article/pii/S1534580722008164

Ribeiro, J., & Crossan, G. P. (2023). GCNA is a histone binding protein required for spermatogonial stem cell maintenance. Nucleic Acids Research51(10), 4791-4813.
https://academic.oup.com/nar/article/51/10/4791/7078046
* PD0325901 and CHIR99021 from Axon Medchem

Baden, P., Perez, M. J., Raji, H., Bertoli, F., Kalb, S., Illescas, M., ... & Deleidi, M. (2023). Glucocerebrosidase is imported into mitochondria and preserves complex I integrity and energy metabolism. Nature Communications14(1), 1930.
https://www.nature.com/articles/s41467-023-37454-4

van Amerongen, R. A., Morton, L. T., Chaudhari, U. G., Remst, D. F., Hagedoorn, R. S., van den Berg, C. W., ... & Heemskerk, M. H. (2023). Human iPSC-derived preclinical models to identify toxicity of tumor-specific T cells with clinical potential. Molecular Therapy-Methods & Clinical Development.
https://www.sciencedirect.com/science/article/pii/S2329050123000074

Ballmer, D., Tardat, M., Ortiz, R., Graff-Meyer, A., Ozonov, E. A., Genoud, C., ... & Fanourgakis, G. (2023). HP1 proteins regulate nucleolar structure and function by secluding pericentromeric constitutive heterochromatin. Nucleic Acids Research51(1), 117-143.
https://academic.oup.com/nar/article/51/1/117/6931869
* CHIR99021 and PD184352 from Axon Medchem

Sakuma, K., Tsubooka-Yamazoe, N., Hashimoto, K., Sakai, N., Asano, S., Watanabe-Matsumoto, S., ... & Toyoda, T. (2023). CDK8/19 inhibition plays an important role in pancreatic β-cell induction from human iPSCs. Stem Cell Research & Therapy14(1), 1.
https://link.springer.com/article/10.1186/s13287-022-03220-4

Sun, J., Osenberg, S., Irwin, A., Ma, L. H., Lee, N., Xiang, Y., ... & Ballas, N. (2023). Mutations in the transcriptional regulator MeCP2 severely impact key cellular and molecular signatures of human astrocytes during maturation. Cell Reports42(1), 111942.
https://www.sciencedirect.com/science/article/pii/S2211124722018435

Kaemena, D. F., Yoshihara, M., Beniazza, M., Ashmore, J., Zhao, S., Bertenstam, M., ... & Kaji, K. (2023). B1 SINE-binding ZFP266 impedes mouse iPSC generation through suppression of chromatin opening mediated by reprogramming factors. Nature Communications14(1), 488.
https://www.nature.com/articles/s41467-023-36097-9
* 2i: PD0325901 and CHIR99021 from Axon Medchem

Schüle, K. M., Weckerle, J., Probst, S., Wehmeyer, A. E., Zissel, L., Schröder, C. M., ... & Arnold, S. J. (2023). Eomes restricts Brachyury functions at the onset of mammalian gastrulation. bioRxiv, 2023-01.
https://www.biorxiv.org/content/10.1101/2023.01.27.525830.abstract
* 2i: PD0325901 and CHIR99021 from Axon Medchem

Messelodi, D., Strocchi, S., Bertuccio, S. N., Baden, P., Indio, V., Giorgi, F. M., ... & Pession, A. (2023). Neuronopathic Gaucher disease models reveal defects in cell growth promoted by Hippo pathway activation. Communications Biology6(1), 431.
https://www.nature.com/articles/s42003-023-04813-2

Breitmeyer, R., Vogel, S., Heider, J., Hartmann, S. M., Wüst, R., Keller, A. L., ... & Volkmer, H. (2023). Regulation of synaptic connectivity in schizophrenia spectrum by mutual neuron-microglia interaction. Communications Biology6(1), 472.
https://www.nature.com/articles/s42003-023-04852-9

Ito, R., Kimura, A., Hirose, Y., Hatano, Y., Mima, A., Mae, S. I., ... & Osafune, K. (2023). Elucidation of HHEX in pancreatic endoderm differentiation using a human iPSC differentiation model. Scientific Reports13(1), 8659.
https://www.nature.com/articles/s41598-023-35875-1

Ensinck, I., Sideri, T., Modic, M., Capitanchik, C., Vivori, C., Toolan-Kerr, P., & van Werven, F. J. (2023). m6A-ELISA, a simple method for quantifying N6-methyladenosine from mRNA populations. RNA29(5), 705-712.
https://rnajournal.cshlp.org/content/29/5/705.full

Park, P. J., & Christopher, C. A. W. Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory 2 elements 3.
https://biblio.ugent.be/publication/8771508/file/8771527.pdf

Sambri, I., Ferniani, M., Campostrini, G., Testa, M., Meraviglia, V., de Araujo, M. E., ... & Ballabio, A. (2023). RagD auto-activating mutations impair MiT/TFE activity in kidney tubulopathy and cardiomyopathy syndrome. Nature Communications14(1), 2775.
https://www.nature.com/articles/s41467-023-38428-2

Linneberg-Agerholm, M., Sell, A. C., Redo-Riveiro, A., Proks, M., Knudsen, T. E., Perera, M., & Brickman, J. M. (2023). Enhancer status in the primitive endoderm supports unrestricted lineage plasticity in regulative development. bioRxiv, 2023-05.
https://www.biorxiv.org/content/10.1101/2023.05.20.540779.abstract

Meier, A. B., Zawada, D., De Angelis, M. T., Martens, L. D., Santamaria, G., Zengerle, S., ... & Moretti, A. (2023). Epicardioid single-cell genomics uncovers principles of human epicardium biology in heart development and disease. Nature Biotechnology, 1-14.
https://www.nature.com/articles/s41587-023-01718-7

Arena, G., Landoulsi, Z., Grossmann, D., Vitali, A., Delcambre, S., Baron, A., ... & Gruenewald, A. (2023). Polygenic risk scores validated in patient-derived cells stratify for mitochondrial subtypes of Parkinson's disease. medRxiv, 2023-05.
https://www.medrxiv.org/content/10.1101/2023.05.12.23289877.abstract

van der Veer, B. K., Chen, L., Custers, C., Athanasouli, P., Schroiff, M., Cornelis, R., ... & Koh, K. P. (2023). Dual functions of TET1 in germ layer lineage bifurcation distinguished by genomic context and dependence on 5-methylcytosine oxidation. Nucleic Acids Research, gkad231.
https://academic.oup.com/nar/advance-article-abstract/doi/10.1093/nar/gkad231/7109501

Rivera‐Arbeláez, J. M., Keekstra, D., Cofiño‐Fabres, C., Boonen, T., Dostanic, M., Ten Den, S. A., ... & Passier, R. (2023). Automated assessment of human engineered heart tissues using deep learning and template matching for segmentation and tracking. Bioengineering & Translational Medicine, e10513.
https://aiche.onlinelibrary.wiley.com/doi/abs/10.1002/btm2.10513

Jones, C., Avino, M., Giroux, V., & Boudreau, F. (2023). HNF4α acts as upstream functional regulator of intestinal Wnt3 and paneth cell fate. Cellular and Molecular Gastroenterology and Hepatology15(3), 593-612.
https://www.sciencedirect.com/science/article/pii/S2352345X22002466

Arena, G., Landoulsi, Z., Grossmann, D., Vitali, A., Delcambre, S., Baron, A., ... & Grünewald, A. (2023). Polygenic risk scores validated in patient-derived cells stratify for mitochondrial subtypes of Parkinson\textquoterights disease 2023.05. 12.23289877.
https://orbilu.uni.lu/bitstream/10993/55367/1/2023.05.12.23289877v1.full.pdf

Dane, T. L., Gill, A. L., Vieira, F. G., & Denton, K. R. (2023). Reduced C9orf72 expression exacerbates polyGR toxicity in patient iPSC-derived motor neurons and a Type I protein arginine methyltransferase inhibitor reduces that toxicity. Frontiers in Cellular Neuroscience17, 1134090.
https://www.frontiersin.org/articles/10.3389/fncel.2023.1134090/full

Hermann, F. M., Kjærgaard, M. F., Tian, C., Tiemann, U., Jackson, A., Olsen, L. R., ... & Semb, H. (2023). An insulin hypersecretion phenotype precedes pancreatic β cell failure in MODY3 patient-specific cells. Cell Stem Cell30(1), 38-51.
https://www.sciencedirect.com/science/article/pii/S1934590922004854
* CHIR99021 and R428 from Axon Medchem

van Royen, M. E., IJcken, W. F. J., French, P., Bedalov, A., & Gribnau, J. H. Mira-Bontenbal,* B. Tan, C. Gontan, S. Goossens, RG Boers, JB Boers, C. Dupont.
https://pure.eur.nl/ws/files/80795622/PIIS2213671122000522.pdf

Tamura, T., Ito, J., Uriu, K., Zahradnik, J., Kida, I., Anraku, Y., ... & Sato, K. (2023). Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants. Nature communications14(1), 2800.
https://www.nature.com/articles/s41467-023-38435-3

Kranaster, P., Blum, J., Dold, J. E., Wittmann, V., & Leist, M. (2023). Use of metabolic glycoengineering and pharmacological inhibitors to assess lipid and protein sialylation on cells. Journal of Neurochemistry164(4), 481-498.
https://onlinelibrary.wiley.com/doi/abs/10.1111/jnc.15737

Lechado-Terradas, A., Schepers, S., Zittlau, K. I., Sharma, K., Ok, O., Fitzgerald, J. C., ... & Kahle, P. J. (2022). Parkin-dependent mitophagy occurs via proteasome-dependent steps sequentially targeting separate mitochondrial sub-compartments for autophagy. Autophagy Reports1(1), 576-602.
https://www.tandfonline.com/doi/abs/10.1080/27694127.2022.2143214

Ito, J., Suzuki, R., Uriu, K., Itakura, Y., Zahradnik, J., Kimura, K. T., ... & Sato, K. (2023). Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ. 1.1 variant. Nature communications14(1), 2671.
https://www.nature.com/articles/s41467-023-38188-z

Patberg, M., Oniani, T., Disse, P., Peischard, S., Vinnenberg, L., Zobeiri, M., ... & Junker, A. (2023). Optimized synthesis and pharmacological evaluation of HCN channel inhibitor EC18. Archiv der Pharmazie356(6), 2200665.
https://onlinelibrary.wiley.com/doi/abs/10.1002/ardp.202200665

Tasca, F. Shepherding precision gene editing ith CRISPR-Cas9 ariants and adeno iral ectors.
https://scholarlypublications.universiteitleiden.nl/access/item%3A3620385/download

Katsuda, T., Li, J., Merrell, A. J., Sussman, J., Matsuzaki, J., Ochiya, T., & Stanger, B. Z. (2023). Evidence for in vitro extensive proliferation of adult hepatocytes and biliary epithelial cells. bioRxiv, 2023-01.
https://www.biorxiv.org/content/10.1101/2023.01.03.522656.abstract

Gil, N., Perry, R. B. T., Mukamel, Z., Tuck, A., Bühler, M., & Ulitsky, I. (2023). Complex regulation of Eomes levels mediated through distinct functional features of the Meteor long non-coding RNA locus. Cell Reports42(6).
https://www.cell.com/cell-reports/pdf/S2211-1247(23)00580-6.pdf
* PD0325901, CHIR99021 and Y27632 from Axon Medchem

Sierra-Delgado, J. A., Sinha-Ray, S., Kaleem, A., Ganjibakhsh, M., Parvate, M., Powers, S., ... & Meyer, K. (2023). In Vitro Modeling as a Tool for Testing Therapeutics for Spinal Muscular Atrophy and IGHMBP2-Related Disorders. Biology12(6), 867.
https://www.mdpi.com/2079-7737/12/6/867

Zittlau, K. I. (2023). Temporal analysis of parkin-dependent mitophagy using mass spectrometry-based proteomics(Doctoral dissertation, Universität Tübingen).
https://tobias-lib.ub.uni-tuebingen.de/xmlui/handle/10900/136757

Robertson, F. L., O’Duibhir, E., Gangoso, E., Bressan, R. B., Bulstrode, H., Marqués-Torrejón, M. Á., ... & Pollard, S. M. (2023). Elevated FOXG1 in glioblastoma stem cells cooperates with Wnt/β-catenin to induce exit from quiescence. Cell Reports42(6).
https://www.cell.com/cell-reports/pdf/S2211-1247(23)00572-7.pdf

Schwarz, L. (2023). Miro1-mutant iPSC-derived Neurons reveal novel functions of Miro1 in mitochondrial respiration and dopamine handling (Doctoral dissertation, Universität Tübingen).
https://tobias-lib.ub.uni-tuebingen.de/xmlui/handle/10900/138359
* dorsomorphin and CHIR99021 from Axon medchem

Sinenko, S. A., Kuzmin, A. A., Skvortsova, E. V., Ponomartsev, S. V., Efimova, E. V., Bader, M., ... & Tomilin, A. N. (2023). Tryptophan hydroxylase-2-mediated serotonin biosynthesis suppresses cell reprogramming into pluripotent state. International Journal of Molecular Sciences24(5), 4862.
https://www.mdpi.com/1422-0067/24/5/4862
* 2i: PD0325901 and CHIR99021 from Axon Medchem

Zujur, D., Al-Akashi, Z., Nakamura, A., Zhao, C., Takahashi, K., Aritomi, S., ... & Ikeya, M. (2023). Enhanced chondrogenic differentiation of iPS cell-derived mesenchymal stem/stromal cells via neural crest cell induction for hyaline cartilage repair. Frontiers in Cell and Developmental Biology11, 1140717.
https://www.frontiersin.org/articles/10.3389/fcell.2023.1140717/full

Miyashita, R., Nishiyama, A., Qin, W., Chiba, Y., Kori, S., Kato, N., ... & Nakanishi, M. (2023). The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD5. Elife12, e79013.
https://elifesciences.org/articles/79013
* 2i: PD0325901 and CHIR99021 from Axon Medchem

Γκουγκούσης, Χ. (2023). Πρωτεωμικός χαρακτηρισμός καρδιομυοκυττάρων προερχόμενων από εμβρυονικά βλαστικά κύτταρα ανθρώπου (Master's thesis).
https://olympias.lib.uoi.gr/jspui/bitstream/123456789/32597/4/Μ.Ε.%20ΓΚΟΥΓΚΟΥΣΗΣ%20ΧΡΗΣΤΟΣ%202023.pdf

Sato, S., Hishida, T., Kinouchi, K., Hatanaka, F., Li, Y., Nguyen, Q., ... & Sassone-Corsi, P. (2023). The circadian clock CRY1 regulates pluripotent stem cell identity and somatic cell reprogramming. Cell Reports42(6).
https://www.cell.com/cell-reports/pdf/S2211-1247(23)00601-0.pdf
* CHIR99021 and SB202190 from Axon Medchem

Bernardini, A., Mukherjee, P., Scheer, E., Kamenova, I., Antonova, S., Sanchez, P. K. M., ... & Tora, L. (2023). Hierarchical TAF1-dependent co-translational assembly of the basal transcription factor TFIID. bioRxiv, 2023-04.
https://www.biorxiv.org/content/10.1101/2023.04.05.535704.abstract
* 2i: PD0325901 and CHIR99021 from Axon Medchem

Luna Velez, M. V., Neikes, H. K., Snabel, R. R., Quint, Y., Qian, C., Martens, A., ... & Vermeulen, M. (2023). ONECUT2 regulates RANKL-dependent enterocyte and microfold cell differentiation in the small intestine; a multi-omics study. Nucleic Acids Research.
https://academic.oup.com/nar/advance-article-abstract/doi/10.1093/nar/gkac1236/6981654

Noviello, G., Gjaltema, R. A., & Schulz, E. G. (2023). CasTuner is a degron and CRISPR/Cas-based toolkit for analog tuning of endogenous gene expression. Nature Communications14(1), 3225.
https://www.nature.com/articles/s41467-023-38909-4
* 2i: PD0325901 and CHIR99021 from Axon Medchem

2022 (121 citations)
Romayor, I., Herrera, L., Burón, M., Martin-Inaraja, M., Prieto, L., Etxaniz, J., ... & Eguizabal, C. (2022). A Comparative Study of Cell Culture Conditions during Conversion from Primed to Naive Human Pluripotent Stem Cells. Biomedicines10(6), 1358.
https://www.mdpi.com/2227-9059/10/6/1358
* CHIR99021, PD0325901, Y27632, Go6983, SP600125 and BIRB796 from Axon Medchem

Zorzan, I., Betto, R. M., Rossignoli, G., Arboit, M., Drusin, A., Martini, P., & Martello, G. (2022). Chemical conversion of human conventional Pluripotent Stem Cells to Trophoblast Stem Cells. bioRxiv, 2022-04.
https://www.biorxiv.org/content/10.1101/2022.04.07.487453v1.full
*PD0325901, XAV939, Go6983, Y27632, CHIR99021, A83-01, SB431542 from Axon Medchem

Viukov, S., Shani, T., Bayerl, J., Sheban, D., Stelzer, Y., Novershtern, N., & Hanna, J. H. (2022). Human primed and naïve PSCs are both competent in differentiating into bona fide trophoblast stem cells. BioRxiv, 2022-05.
https://www.biorxiv.org/content/10.1101/2022.05.20.492766v1.full
*PD0325901, XAV939, GO6983, CGP77675, BIRB796, A883-01, CHIR99021, Y27632 from Axon Medchem

Takao, T., Yamada, D., & Takarada, T. (2022). A protocol to induce expandable limb-bud mesenchymal cells from human pluripotent stem cells. STAR protocols3(4), 101786.
https://www.sciencedirect.com/science/article/pii/S2666166722006669

Marini, V., Marino, F., Aliberti, F., Giarratana, N., Pozzo, E., Duelen, R., ... & Chai, Y. C. (2022). Long-term culture of patient-derived cardiac organoids recapitulated Duchenne muscular dystrophy cardiomyopathy and disease progression. Frontiers in Cell and Developmental Biology10, 878311.
https://www.frontiersin.org/articles/10.3389/fcell.2022.878311/full

Tada, T., Ohnishi, H., Yamamoto, N., Kuwata, F., Hayashi, Y., Okuyama, H., ... & Omori, K. (2022). Transplantation of a human induced pluripotent stem cell-derived airway epithelial cell sheet into the middle ear of rats. Regenerative Therapy19, 77-87.
https://www.sciencedirect.com/science/article/pii/S2352320422000013

Montero-Calle, P., Flandes-Iparraguirre, M., Mountris, K., S de la Nava, A., Laita, N., Rosales, R. M., ... & Mazo, M. M. (2022). Fabrication of human myocardium using multidimensional modelling of engineered tissues. Biofabrication14(4), 045017.
https://iopscience.iop.org/article/10.1088/1758-5090/ac8cb3/meta
* CHIR99021 and C59 from Axon Medchem

Viegas, J. O., Azad, G. K., Lv, Y., Fishman, L., Paltiel, T., Pattabiraman, S., ... & Meshorer, E. (2022). RNA degradation eliminates developmental transcripts during murine embryonic stem cell differentiation via CAPRIN1-XRN2. Developmental Cell57(24), 2731-2744.
https://www.sciencedirect.com/science/article/pii/S1534580722008140
* 2i: PD0325901 and CHIR99021 from Axon Medchem

Kuwata, F., Ohnishi, H., Yamamoto, N., Takezawa, T., Yamashita, M., Okuyama, H., ... & Omori, K. (2022). Transplantation of Human Induced Pluripotent Stem Cell-Derived Airway Cells on Vitrigel Membrane into Rat Nasal Cavity. Tissue Engineering Part A28(13-14), 586-594.
https://www.liebertpub.com/doi/abs/10.1089/ten.TEA.2021.0071

Stolz, P., Mantero, A. S., Tvardovskiy, A., Ugur, E., Wange, L. E., Mulholland, C. B., ... & Bultmann, S. (2022). TET1 regulates gene expression and repression of endogenous retroviruses independent of DNA demethylation. Nucleic Acids Research50(15), 8491-8511.
https://academic.oup.com/nar/article/50/15/8491/6651872
*2i; PD0325901 and CHIR99021 from Axon Medchem

Cao, X., Mircea, M., Yakala, G. K., van den Hil, F. E., Brescia, M., Mei, H., ... & Orlova, V. V. (2023). ETV2 upregulation marks the specification of early cardiomyocytes and endothelial cells during co-differentiation. Stem Cells41(2), 140-152.
https://academic.oup.com/stmcls/article/41/2/140/6895495

Tarazi, S., Aguilera-Castrejon, A., Joubran, C., Ghanem, N., Ashouokhi, S., Roncato, F., ... & Hanna, J. H. (2022). Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs. Cell185(18), 3290-3306.
https://www.sciencedirect.com/science/article/pii/S0092867422009813
* CHIR99021, PD0325901, Y27632 from Axon Medchem

Rousset, F., Schilardi, G., Sgroi, S., Nacher-Soler, G., Sipione, R., Kleinlogel, S., & Senn, P. (2022). WNT Activation and TGFβ-Smad Inhibition Potentiate Stemness of Mammalian Auditory Neuroprogenitors for High-Throughput Generation of Functional Auditory Neurons In Vitro. Cells11(15), 2431.
https://www.mdpi.com/2073-4409/11/15/2431
* CHIR99021, LND193189 and SB431542 from Axon Medchem

Miura, Y., Sato, M., Kuwahara, T., Ebata, T., Tabata, Y., & Sakurai, H. (2022). Transplantation of human iPSC-derived muscle stem cells in the diaphragm of Duchenne muscular dystrophy model mice. Plos one17(4), e0266391.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0266391

Peischard, S., Möller, M., Disse, P., Ho, H. T., Verkerk, A. O., Strutz-Seebohm, N., ... & Seebohm, G. (2022). Virus-induced inhibition of cardiac pacemaker channel HCN4 triggers bradycardia in human-induced stem cell system. Cellular and Molecular Life Sciences79(8), 440.
https://link.springer.com/article/10.1007/s00018-022-04435-7
* CHIR99021 and CID 1067700 (ML282) from Axon Medchem

Girard, O., Lavigne, R., Chevolleau, S., Onfray, C., Com, E., Schmit, P. O., ... & Pineau, C. (2022). Naive Pluripotent and Trophoblastic Stem Cell Lines as a Model for Detecting Missing Proteins in the Context of the Chromosome-Centric Human Proteome Project. Journal of proteome research.
https://pubs.acs.org/doi/abs/10.1021/acs.jproteome.2c00496
* PD0325901, XAV939, GO6983, Y27632 and CHIR99021 from Axon Medchem

Kuwata, F. (2022). Transplantation of human iPS cell-derived airway cells on vitrigel membrane into rat nasal cavity.
https://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/276161/1/digak04869.pdf

Alonso-Alonso, S., Santaló, J., & Ibáñez, E. (2022). Efficient generation of embryonic stem cells from single blastomeres of cryopreserved mouse embryos in the presence of signalling modulators. Reproduction, Fertility and Development34(7), 576-587.
https://www.publish.csiro.au/RD/RD21297
* 2i : PD0325901 and CHIR99021 from Axon Medchem

Trikalitis, V. D., Kroese, N. J., Kaya, M., Cofiño-Fabres, C., Ten Den, S., Khalil, I. S., ... & Rouwkema, J. (2022). Embedded 3D printing of dilute particle suspensions into dense complex tissue fibers using shear thinning xanthan baths. Biofabrication15(1), 015014.
https://iopscience.iop.org/article/10.1088/1758-5090/aca124/meta

Luquette, L. J., Miller, M. B., Zhou, Z., Bohrson, C. L., Zhao, Y., Jin, H., ... & Park, P. J. (2022). Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements. Nature Genetics54(10), 1564-1571.
https://www.nature.com/articles/s41588-022-01180-2
*2i; PD0325901 and CHIR99021 from Axon Medchem

Pham, T. X. A., Panda, A., Kagawa, H., Ertekin, C., Georgolopoulos, G., van Knippenberg, S. S., ... & Pasque, V. (2022). Modeling human extraembryonic mesoderm cells using naive pluripotent stem cells. Cell Stem Cell29(9), 1346-1365.
https://www.sciencedirect.com/science/article/pii/S193459092200337X
* PD0325901, SB431542, CHIR99021, from Axon Medchem

Wakimizu, T., Morikawa, K., Fukumura, K., Yuki, T., Adachi, T., Kurata, Y., ... & Shirayoshi, Y. (2022). SHOX2 refines the identification of human sinoatrial nodal cell population in the in vitro cardiac differentiation. Regenerative Therapy21, 239-249.
https://www.sciencedirect.com/science/article/pii/S2352320422000694

Coppiello, G., Barlabe, P., Moya-Jodar, M., Abizanda, G., Barreda, C., Iglesias, E., ... & Aranguren, X. L. (2022). In vivo generation of heart and vascular system by blastocyst complementation. bioRxiv, 2022-10.
https://www.biorxiv.org/content/10.1101/2022.10.04.510637.abstract
* 2i: PD0325901 and CHIR99021 from Axon Medchem

Hiltunen, A. E., Vuolteenaho, R., Ronkainen, V. P., Miinalainen, I., Uusimaa, J., Lehtonen, S., & Hinttala, R. (2022). Nhlrc2 is crucial during mouse gastrulation. genesis60(3), e23470.
https://onlinelibrary.wiley.com/doi/abs/10.1002/dvg.23470
* 2i: PD0325901 and CHIR99021 from Axon Medchem

Rivera-Arbeláez, J. M., Cofiño-Fabres, C., Schwach, V., Boonen, T., Ten Den, S. A., Vermeul, K., ... & Passier, R. (2022). Contractility analysis of human engineered 3D heart tissues by an automatic tracking technique using a standalone application. Plos one17(4), e0266834.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0266834

Gu, Y., Zhou, Y., Ju, S., Liu, X., Zhang, Z., Guo, J., ... & Hu, Z. (2022). Multi-omics profiling visualizes dynamics of cardiac development and functions. Cell Reports41(13), 111891.
https://www.sciencedirect.com/science/article/pii/S2211124722017909

Zagare, A., Barmpa, K., Smajic, S., Smits, L. M., Grzyb, K., Grünewald, A., ... & Schwamborn, J. C. (2022). Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p. Gly2019Ser-associated gene expression. The American Journal of Human Genetics109(2), 311-327.
https://www.sciencedirect.com/science/article/pii/S000292972100464X

van Neerven, S. M., Smit, W. L., van Driel, M. S., Kakkar, V., de Groot, N. E., Nijman, L. E., ... & Vermeulen, L. (2022). Intestinal Apc‐inactivation induces HSP25 dependency. EMBO Molecular Medicine, e16194.
https://www.embopress.org/doi/full/10.15252/emmm.202216194

Tamai, K., Sakai, K., Yamaki, H., Moriguchi, K., Igura, K., Maehana, S., ... & Gotoh, S. (2022). iPSC-derived mesenchymal cells that support alveolar organoid development. Cell Reports Methods2(10), 100314.
https://www.sciencedirect.com/science/article/pii/S2667237522002041

Cao, X., & Mircea, M. (2022). akala, GK, Hil, FE an den, Brescia, M. Mei, HL,… Orlo a5, 140-152.
https://scholarlypublications.universiteitleiden.nl/access/item%3A3594532/download

Kwok, C. K., Sébastien, I., Hariharan, K., Meiser, I., Wihan, J., Altmaier, S., ... & Zimmermann, H. (2022). Scalable expansion of iPSC and their derivatives across multiple lineages. Reproductive Toxicology112, 23-35.
https://www.sciencedirect.com/science/article/pii/S0890623822000685

Hauth, A., Galupa, R., Servant, N., Villacorta, L., Hauschulz, K., van Bemmel, J. G., ... & Heard, E. (2022). Deciphering High-Resolution 3D Chromatin Organization via Capture Hi-C. JoVE (Journal of Visualized Experiments), (188), e64166.
https://www.jove.com/t/64166/deciphering-high-resolution-3d-chromatin-organization-via-capture-hi-c
* 2i: PD0325901 and CHIR99021 from Axon Medchem

Bérenger-Currias, N. M., Mircea, M., Adegeest, E., van den Berg, P. R., Feliksik, M., Hochane, M., ... & Semrau, S. (2022). A gastruloid model of the interaction between embryonic and extra-embryonic cell types. Journal of Tissue Engineering13, 20417314221103042.
https://journals.sagepub.com/doi/pdf/10.1177/20417314221103042

Dekel, C., Morey, R., Hanna, J., Laurent, L. C., Ben-Yosef, D., & Amir, H. (2022). Stabilization of hESCs in two distinct substates along the continuum of pluripotency. Iscience25(12), 105469.
https://www.sciencedirect.com/science/article/pii/S2589004222017412
* CHIR99021, PD0325901, BIRB796, CGP77675 and Y27632 from Axon Medchem

Kamiya, D., Takenaka-Ninagawa, N., Motoike, S., Kajiya, M., Akaboshi, T., Zhao, C., ... & Ikeya, M. (2022). Induction of functional xeno-free MSCs from human iPSCs via a neural crest cell lineage. npj Regenerative Medicine7(1), 47.
https://www.nature.com/articles/s41536-022-00241-8

Higa, T., Okita, Y., Matsumoto, A., Nakayama, S., Oka, T., Sugahara, O., ... & Nakayama, K. I. (2022). Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium. Nature communications13(1), 1500.
https://www.nature.com/articles/s41467-022-29165-z

López-Muneta, L., Linares, J., Casis, O., Martínez-Ibáñez, L., González Miqueo, A., Bezunartea, J., ... & Carvajal-Vergara, X. (2022). Generation of NKX2. 5GFP reporter human iPSCs and differentiation into functional cardiac fibroblasts. Frontiers in Cell and Developmental Biology9, 3669.
https://www.frontiersin.org/articles/10.3389/fcell.2021.797927/full

Blanch-Asensio, A., Grandela, C., Brandão, K. O., de Korte, T., Mei, H., Ariyurek, Y., ... & Davis, R. P. (2022). STRAIGHT-IN enables high-throughput targeting of large DNA payloads in human pluripotent stem cells. Cell Reports Methods2(10), 100300.
https://www.sciencedirect.com/science/article/pii/S2667237522001825

Spreng, A. S., Brüll, M., Leisner, H., Suciu, I., & Leist, M. (2022). Distinct and Dynamic Transcriptome Adaptations of iPSC-Generated Astrocytes after Cytokine Stimulation. Cells 2022, 11, 2644.
https://kops.uni-konstanz.de/server/api/core/bitstreams/25d55d0c-2b3c-448e-a44b-ac4f70eebe67/content

Yue, Z. H. O. U., Chen, C. H. E. N. G., Enlin, Z. H. E. N. G., Zhuo, M. E. N. G., Jian, W. A. N. G., Qingjie, W. A. N. G., & Yongning, H. E. (2022). Exploring potential new receptors for ELABELA in human embryonic stem cells by Crispr/Cas9-mediated gene editing system. Journal of Shanghai Jiao Tong University (Medical Science)42(9), 1258.
https://xuebao.shsmu.edu.cn/EN/abstract/abstract13498.shtml

Yoshida, Y., Takahashi, M., Yamanishi, H., Nakazawa, Y., Kishimoto, J., & Ohyama, M. (2022). Changes in the Expression of Smooth Muscle Cell–Related Genes in Human Dermal Sheath Cup Cells Associated with the Treatment Outcome of Autologous Cell–Based Therapy for Male and Female Pattern Hair Loss. International Journal of Molecular Sciences23(13), 7125.
https://www.mdpi.com/1422-0067/23/13/7125

Zijlmans, D. W., Talon, I., Verhelst, S., Bendall, A., Van Nerum, K., Javali, A., ... & Pasque, V. (2022). Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction. Nature Cell Biology24(6), 858-871.
https://www.nature.com/articles/s41556-022-00932-w
* PD0325901, CHIR99021 and SB431542 from Axon Medchem

Costamagna, D., Casters, V., Beltrà, M., Sampaolesi, M., Van Campenhout, A., Ortibus, E., ... & Duelen, R. (2022). Autologous iPSC-Derived Human Neuromuscular Junction to Model the Pathophysiology of Hereditary Spastic Paraplegia. Cells11(21), 3351.
https://www.mdpi.com/1903718

Li, J., Wiesinger, A., Fokkert, L., Boukens, B. J., Verkerk, A. O., Christoffels, V. M., ... & Devalla, H. D. (2022). Molecular and electrophysiological evaluation of human cardiomyocyte subtypes to facilitate generation of composite cardiac models. Journal of Tissue Engineering13, 20417314221127908.
https://journals.sagepub.com/doi/pdf/10.1177/20417314221127908

Tasca, F., Brescia, M., Wang, Q., Liu, J., Janssen, J. M., Szuhai, K., & Gonçalves, M. A. (2022). Large-scale genome editing based on high-capacity adenovectors and CRISPR-Cas9 nucleases rescues full-length dystrophin synthesis in DMD muscle cells. Nucleic Acids Research50(13), 7761-7782.
https://academic.oup.com/nar/article-abstract/50/13/7761/6625817

Wu, X., Ciminieri, C., Bos, I. S. T., Woest, M. E., D'Ambrosi, A., Wardenaar, R., ... & Gosens, R. (2022). Diesel exhaust particles distort lung epithelial progenitors and their fibroblast niche. Environmental Pollution305, 119292.
https://www.sciencedirect.com/science/article/pii/S0269749122005061

Tamura, T., Yamasoba, D., Oda, Y., Ito, J., Kamasaki, T., Nao, N., ... & Fukuhara, T. (2022). Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA. 1, BA. 2, and BA. 5. bioRxiv, 2022-08.
https://www.biorxiv.org/content/10.1101/2022.08.05.502758.abstract

Choy Buentello, D., Koch, L. S., Trujillo-de Santiago, G., Alvarez, M. M., & Broersen, K. (2022). Use of standard U-bottom and V-bottom well plates to generate neuroepithelial embryoid bodies. Plos one17(5), e0262062.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0262062

Smith, A. S., Luttrell, S. M., Dupont, J. B., Gray, K., Lih, D., Fleming, J. W., ... & Mack, D. L. (2022). High-throughput, real-time monitoring of engineered skeletal muscle function using magnetic sensing. Journal of Tissue Engineering13, 20417314221122127.
https://journals.sagepub.com/doi/pdf/10.1177/20417314221122127

Vivas, A., van den Berg, A., Passier, R., Odijk, M., & van der Meer, A. D. (2022). Fluidic circuit board with modular sensor and valves enables stand-alone, tubeless microfluidic flow control in organs-on-chips. Lab on a Chip22(6), 1231-1243.
https://pubs.rsc.org/en/content/articlehtml/2022/lc/d1lc00999k

Hiyoshi, H., Sakuma, K., Tsubooka-Yamazoe, N., Asano, S., Mochida, T., Yamaura, J., ... & Toyoda, T. (2022). Characterization and reduction of non-endocrine cells accompanying islet-like endocrine cells differentiated from human iPSC. Scientific Reports12(1), 4740.
https://www.nature.com/articles/s41598-022-08753-5

Nalbandian, M., Zhao, M., Kato, H., Jonouchi, T., Nakajima-Koyama, M., Yamamoto, T., & Sakurai, H. (2022). Single-cell RNA-seq reveals heterogeneity in hiPSC-derived muscle progenitors and E2F family as a key regulator of proliferation. Life Science Alliance5(8).
https://www.life-science-alliance.org/content/5/8/e202101312.abstract

Desloovere, K., Verfaillie, C. M., Sipido, K. R., Buyse, G. M., & Sampaolesi, M. Robin Duelen, Domiziana Costamagna, Guillaume Gilbert, 3 Liesbeth De Waele, 4 Nathalie Goemans, 4. Stem Cell Reports (2022), https://doi.org/10.1016/j.stemcr.2021.12.019
https://www.researchgate.net/profile/Robin-Duelen/publication/358187131_Human_iPSC_model_reveals_a_central_role_for_NOX4_and_oxidative_stress_in_Duchenne_cardiomyopathy/links/61f92001007fb504472ca672/Human-iPSC-model-reveals-a-central-role-for-NOX4-and-oxidative-stress-in-Duchenne-cardiomyopathy.pdf

Ozawa, M., Taguchi, J., Katsuma, K., Ishikawa-Yamauchi, Y., Kikuchi, M., Sakamoto, R., ... & Ikawa, M. (2022). Efficient simultaneous double DNA knock-in in murine embryonic stem cells by CRISPR/Cas9 ribonucleoprotein-mediated circular plasmid targeting for generating gene-manipulated mice. Scientific Reports12(1), 21558.
https://www.nature.com/articles/s41598-022-26107-z

Yoshimoto, Y., Uezumi, A., Ikemoto-Uezumi, M., Tanaka, K., Yu, X., Kurosawa, T., ... & Shukunami, C. (2022). Tenogenic Induction From Induced Pluripotent Stem Cells Unveils the Trajectory Towards Tenocyte Differentiation. Frontiers in Cell and Developmental Biology10, 780038.
https://www.frontiersin.org/articles/10.3389/fcell.2022.780038/pdf

Fujisawa, Y., Ming, L., Yamada, D., Takao, T., & Takarada, T. (2022). Establishment of a human pluripotent stem cell-derived MKX-td Tomato reporter system. Stem Cell Research & Therapy13(1), 1-8.
https://stemcellres.biomedcentral.com/articles/10.1186/s13287-022-03203-5

Hata, K., Kobayashi, N., Sugimura, K., Qin, W., Haxholli, D., Chiba, Y., ... & Arita, K. (2022). Structural basis for the unique multifaceted interaction of DPPA3 with the UHRF1 PHD finger. Nucleic Acids Research50(21), 12527-12542.
https://academic.oup.com/nar/article-abstract/50/21/12527/6845435

Skvortsova, E. V., Nazarov, I. B., Tomilin, A. N., & Sinenko, S. A. (2022). Dual Mode of Mitochondrial ROS Action during Reprogramming to Pluripotency. International Journal of Molecular Sciences23(18), 10924.
https://www.mdpi.com/1836184
* 2i; PD0325901 and CHIR99021 from Axon Medchem

Nijak, A., Simons, E., Vandendriessche, B., Van de Sande, D., Fransen, E., Sieliwończyk, E., ... & Loeys, B. L. (2022). Morpho-functional comparison of differentiation protocols to create iPSC-derived cardiomyocytes. Biology Open11(2), bio059016.
https://journals.biologists.com/bio/article-abstract/11/2/bio059016/274508

Aguilar, C., Pauzuolis, M., Pompaiah, M., Vafadarnejad, E., Arampatzi, P., Fischer, M., ... & Bartfeld, S. (2022). Helicobacter pylori shows tropism to gastric differentiated pit cells dependent on urea chemotaxis. Nature Communications13(1), 5878.
https://www.nature.com/articles/s41467-022-33165-4
Viukov, S., Shani, T., Bayerl, J., Aguilera-Castrejon, A., Oldak, B., Sheban, D., ... & Novershtern, N. (2022). Human primed and naïve PSCs are both able to differentiate into trophoblast stem cells. Stem cell reports17(11), 2484-2500.
https://www.sciencedirect.com/science/article/pii/S221367112200457X
* PD0325901, XAV939, Go6983, Y27632, CGP77675, PD173074 and CHIR99021 from Axon Medchem

Vierthaler, M. A. (2022). The influence of ADCK2 on melanoma cells and during the development to melanocytic progenitors (NCCs) (Doctoral dissertation).
https://archiv.ub.uni-heidelberg.de/volltextserver/31334/

Harberts, J., Siegmund, M., Hedrich, C., Kim, W., Fontcuberta i Morral, A., Zierold, R., & Blick, R. H. (2022). Generation of Human iPSC‐Derived Neurons on Nanowire Arrays Featuring Varying Lengths, Pitches, and Diameters. Advanced Materials Interfaces9(24), 2200806.
https://onlinelibrary.wiley.com/doi/abs/10.1002/admi.202200806

Ugur, E., de la Porte, A., Bultmann, S., Drukker, M., Mann, M., Wierer, M., & Leonhardt, H. (2022). Comprehensive chromatin proteomics resolves functional phases of pluripotency. bioRxiv, 2022-08.
https://www.biorxiv.org/content/10.1101/2022.08.08.503208v1.full
* 2i; CHIR99021 and PD0325901 from Axon Medchem

Kimura, I., Yamasoba, D., Tamura, T., Nao, N., Suzuki, T., Oda, Y., ... & Sato, K. (2022). Virological characteristics of the SARS-CoV-2 Omicron BA. 2 subvariants, including BA. 4 and BA. 5. Cell185(21), 3992-4007.
https://www.sciencedirect.com/science/article/pii/S0092867422011904

Delás, M. J., Kalaitzis, C. M., Fawzi, T., Demuth, M., Zhang, I., Stuart, H. T., ... & Briscoe, J. (2022). Developmental cell fate choice employs two distinct cis regulatory strategies. bioRxiv, 2022-06.
https://www.biorxiv.org/content/10.1101/2022.06.06.494792v1.full

Duelen, R., Costamagna, D., Gilbert, G., De Waele, L., Goemans, N., Desloovere, K., ... & Sampaolesi, M. (2022). Human iPSC model reveals a central role for NOX4 and oxidative stress in Duchenne cardiomyopathy. Stem Cell Reports17(2), 352-368.
https://www.sciencedirect.com/science/article/pii/S2213671121006585

Ray, S. S., Dutta, D., Dennys, C., Powers, S., Roussel, F., Lisowski, P., ... & Meyer, K. C. (2022). Mechanisms of IRF2BPL-related disorders and identification of a potential therapeutic strategy. Cell Reports41(10), 111751.
https://www.sciencedirect.com/science/article/pii/S2211124722016345

Spreng, A. S., Brüll, M., Leisner, H., Suciu, I., & Leist, M. (2022). Distinct and Dynamic Transcriptome Adaptations of iPSC-Generated Astrocytes after Cytokine Stimulation. Cells11(17), 2644.
https://www.mdpi.com/2073-4409/11/17/2644

Gjaltema, R. A., Schwämmle, T., Kautz, P., Robson, M., Schöpflin, R., Lustig, L. R., ... & Schulz, E. G. (2022). Distal and proximal cis-regulatory elements sense X chromosome dosage and developmental state at the Xist locus. Molecular Cell82(1), 190-208
https://www.sciencedirect.com/science/article/pii/S109727652101025X
* 2i; CHIR99021 and PD0325901 from Axon Medchem

Wiesinger, A., Li, J., Fokkert, L., Bakker, P., Verkerk, A. O., Christoffels, V. M., ... & Devalla, H. D. (2022). A single cell transcriptional roadmap of human pacemaker cell differentiation. Elife11, e76781.
https://elifesciences.org/articles/76781

Ciminieri, C., Wu, X., Bosa, I. S. T., Woesta, M. E., D’Ambrosia, A., Wardenaard, R., ... & Gosens, R. (2022). Diesel exhaust particles distort lung epithelial progenitors and their fibroblast niche. Targeting the COPD lung microenvironment for lung repair: mechanisms and novel therapeutic opportunities305, 159.
https://research.rug.nl/files/560224354/Complete_thesis.pdf#page=160

Coll, M., Ariño, S., Martínez‐Sánchez, C., Garcia‐Pras, E., Gallego, J., Moles, A., ... & Sancho‐Bru, P. (2022). Ductular reaction promotes intrahepatic angiogenesis through Slit2–Roundabout 1 signaling. Hepatology75(2), 353-368.
https://aasldpubs.onlinelibrary.wiley.com/doi/abs/10.1002/hep.32140
* CHIR99021, Forkolin and Y27632 from Axon Medchem

Ramadan, R., Wouters, V. M., van Neerven, S. M., de Groot, N. E., Garcia, T. M., Muncan, V., ... & Huels, D. J. (2022). The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut. Biology Open11(12), bio059544.
https://journals.biologists.com/bio/article-abstract/11/12/bio059544/284355

Rawat, H. (2022). Pleiotropic role of the myocytic cell cycle in congenital heart disease (Doctoral dissertation, Technische Universität München).
https://mediatum.ub.tum.de/1656803

Butti, E., Cattaneo, S., Bacigaluppi, M., Cambiaghi, M., Scotti, G. M., Brambilla, E., ... & Martino, G. (2022). Neural precursor cells tune striatal connectivity through the release of IGFBPL1. Nature Communications13(1), 7579.
https://www.nature.com/articles/s41467-022-35341-y

Ferdaos, N., Lowell, S., & Mason, J. O. (2022). Pax6 mutant cerebral organoids partially recapitulate phenotypes of Pax6 mutant mouse strains. Plos one17(11), e0278147.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0278147
* 2i; CHIR99021 and PD0325901 from Axon Medchem

Song, L., Bekdash, R., Morikawa, K., Quejada, J. R., Klein, A. D., Aina-Badejo, D., ... & Yazawa, M. (2022). Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome. Nature cardiovascular research1(2), 142-156.
https://www.nature.com/articles/s44161-021-00016-2

Zierold1Ε, R., & Blick, R. H. (2022). Robust neuronal differentiation of human iPSC‑derived neural progenitor cells cultured on densely‑spaced spiky silicon nanowire arrays. Electrophysiology of human induced pluripotent stem cell-derived neurons cultivated on micro-and nanostructured substrates11(1), 112.
https://d-nb.info/1272406814/34#page=124

Vivas, A., IJspeert, C., Pan, J. Y., Vermeul, K., van den Berg, A., Passier, R., ... & van der Meer, A. D. (2022). Generation and Culture of Cardiac Microtissues in a Microfluidic Chip with a Reversible Open Top Enables Electrical Pacing, Dynamic Drug Dosing and Endothelial Cell Co‐Culture. Advanced Materials Technologies7(7), 2101355.
https://onlinelibrary.wiley.com/doi/abs/10.1002/admt.202101355

Lehmann, J. I. (2022). Zelldifferenzierung und Selbsterneuerung in porzinen intestinalen Organoiden(Doctoral dissertation, Dissertation, Hannover, Stiftung Tierärztliche Hochschule Hannover, 2022).
https://elib.tiho-hannover.de/servlets/MCRFileNodeServlet/tiho_derivate_00001876/Lehmannj-ws22.pdf

Schwarz, L., & Fitzgerald, J. C. (2022). Steady-state levels of Miro1 linked to phosphorylation at serine 156 and mitochondrial respiration in dopaminergic neurons. Cells11(8), 1269.
https://www.mdpi.com/1580082
* Dorsomorphin and CHIR99021 from Axon Medchem

Fischer, V., Hisler, V., Scheer, E., Lata, E., Morlet, B., Plassard, D., ... & Vincent, S. D. (2022). SUPT3H-less SAGA coactivator can assemble and function without significantly perturbing RNA polymerase II transcription in mammalian cells. Nucleic Acids Research50(14), 7972-7990.
https://academic.oup.com/nar/article-abstract/50/14/7972/6649377
* 2i; CHIR99021 and PD0325901 from Axon Medchem

Takakura, H., Horinaka, M., Imai, A., Aono, Y., Nakao, T., Miyamoto, S., ... & Sakai, T. (2022). Sodium salicylate and 5-aminosalicylic acid synergistically inhibit the growth of human colon cancer cells and mouse intestinal polyp-derived cells. Journal of Clinical Biochemistry and Nutrition70(2), 93.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921728/

Sabaté Soler, S. (2022). INCREASING THE COMPLEXITY OF MIDBRAIN ORGANOID SYSTEMS FOR DEVELOPMENTAL STUDIES AND DISEASE MODELLING(Doctoral dissertation, University of Luxembourg, Belvaux, Luxembourg).
https://orbilu.uni.lu/bitstream/10993/50803/1/PhD%20Thesis_Sònia%20Sabaté%20Soler.pdf

Correia, B., Sousa, M. I., Branco, A. F., Rodrigues, A. S., & Ramalho-Santos, J. (2022). Leucine and Arginine Availability Modulate Mouse Embryonic Stem Cell Proliferation and Metabolism. International Journal of Molecular Sciences23(22), 14286.
https://www.mdpi.com/1953034
* 2i; CHIR99021 and PD0325901 from Axon Medchem

Mira-Bontenbal, H., Tan, B., Gontan, C., Goossens, S., Boers, R. G., Boers, J. B., ... & Gribnau, J. (2022). Genetic and epigenetic determinants of reactivation of Mecp2 and the inactive X chromosome in neural stem cells. Stem Cell Reports17(3), 693-706.
https://www.sciencedirect.com/science/article/pii/S2213671122000522

Schmid, M. (2022). Depicting the role of CDKN2A in pancreatic differentiation exploiting a patient-specific human induced pluripotent stem cell model (Doctoral dissertation, Universität Ulm).
https://oparu.uni-ulm.de/xmlui/handle/123456789/43989
* CHIR99021 and SB432542 from Axon Medchem

Saito, A., Tamura, T., Zahradnik, J., Deguchi, S., Tabata, K., Kimura, I., ... & Sato, K. (2022). Virological characteristics of the SARS-CoV-2 Omicron BA. 2.75. bioRxiv, 2022-08.
https://www.biorxiv.org/content/10.1101/2022.08.07.503115.abstract

Organ-on-a-Chip, A. C. Microfluidic and Microengineered Systems for Automated Cardiac Organ-on-a-Chip Tissue Culture.
https://research.utwente.nl/files/287974408/Thesis_Aisen_Vivas.pdf

Suenaga, R., Konagaya, S., Yamaura, J., Ito, R., Tanaka, S., Ishizaki, Y., & Toyoda, T. (2022). Microwell bag culture for large-scale production of homogeneous islet-like clusters. Scientific reports12(1), 5221.
https://www.nature.com/articles/s41598-022-09124-w

Coda, D. M., Patel, H., Gori, I., Gaarenstroom, T. E., Song, O. R., Howell, M., & Hill, C. S. (2022). A network of transcription factors governs the dynamics of NODAL/Activin transcriptional responses. Journal of Cell Science135(8), jcs259972.
https://journals.biologists.com/jcs/article-abstract/135/8/jcs259972/275130

Saito, A., Tamura, T., Zahradnik, J., Deguchi, S., Tabata, K., Anraku, Y., ... & Sato, K. (2022). Virological characteristics of the SARS-CoV-2 Omicron BA. 2.75 variant. Cell host & microbe30(11), 1540-1555.
https://www.sciencedirect.com/science/article/pii/S1931312822005169

Wehmeyer, A. E., Schüle, K. M., Conrad, A., Schröder, C. M., Probst, S., & Arnold, S. J. (2022). Chimeric 3D gastruloids–a versatile tool for studies of mammalian peri-gastrulation development. Development149(22), dev200812.
https://journals.biologists.com/dev/article/149/22/dev200812/283179/Chimeric-3D-gastruloids-a-versatile-tool-for
* 2i; CHIR99021 and PD0325901 from Axon Medchem

Mamberti, S., Pabba, M. K., Rapp, A., Cardoso, M. C., & Scholz, M. (2022). The Chromatin Architectural Protein CTCF Is Critical for Cell Survival upon Irradiation-Induced DNA Damage. International Journal of Molecular Sciences23(7), 3896.
https://www.mdpi.com/1422-0067/23/7/3896
* 2i; CHIR99021 and PD0325901 from Axon Medchem

Pilotto, F., Schmitz, A., Maharjan, N., Diab, R., Odriozola, A., Tripathi, P., ... & Saxena, S. (2022). PolyGA targets the ER stress-adaptive response by impairing GRP75 function at the MAM in C9ORF72-ALS/FTD. Acta neuropathologica144(5), 939-966.
https://link.springer.com/article/10.1007/s00401-022-02494-5

Di Minin, G., Holzner, M., Grison, A., Dumeau, C. E., Chan, W., Monfort, A., ... & Wutz, A. (2022). TMED2 binding restricts SMO to the ER and Golgi compartments. PLoS Biology20(3), e3001596.
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001596
* 2i; CHIR99021 and PD0325901 from Axon Medchem

Palframan, S. L., Mahmud, M. T., Tan, K. S., Grinter, R., Xin, V., Dunstan, R. A., ... & Kwok, T. (2022). Helicobacter pylori vacuolating cytotoxin A exploits human endosomes for intracellular activation. bioRxiv, 2022-08.
https://www.biorxiv.org/content/10.1101/2022.08.22.504206.abstract

Mukamel, Z., Lifshitz, A., Mittnenzweig, M., Chomsky, E., Schwartzman, O., Ben-Kiki, O., ... & Tanay, A. (2022). DNA methyltransferases 3A and 3B target specific sequences during mouse gastrulation. Nature structural & molecular biology, 1-14.
https://www.nature.com/articles/s41594-022-00885-6
* 2i; CHIR99021 and PD0325901 from Axon Medchem

Arroyo, M., Hastert, F. D., Zhadan, A., Schelter, F., Zimbelmann, S., Rausch, C., ... & Cardoso, M. C. (2022). Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicating heterochromatin modulates methylcytosine oxidation. Nature Communications13(1), 5173.
https://www.nature.com/articles/s41467-022-32799-8
* 2i; CHIR99021 and PD0325901 from Axon Medchem

Knudsen, T. E., Hamilton, W., Proks, M., Lykkegaard, M., Nielsen, A. V., Trusina, A., & Brickman, J. M. (2022). A bipartite function of ESRRB can integrate signaling over time to balance self-renewal and differentiation. bioRxiv, 2022-09.
https://www.biorxiv.org/content/10.1101/2022.09.20.508291.abstract

Mach, P., Kos, P. I., Zhan, Y., Cramard, J., Gaudin, S., Tünnermann, J., ... & Giorgetti, L. (2022). Cohesin and CTCF control the dynamics of chromosome folding. Nature Genetics, 1-12.
https://www.nature.com/articles/s41588-022-01232-7
* 2i; CHIR99021 and PD0325901 from Axon Medchem

Mach, P., Kos, P. I., Zhan, Y., Cramard, J., Gaudin, S., Tünnermann, J., ... & Giorgetti, L. (2022). Live-cell imaging and physical modeling reveal control of chromosome folding dynamics by cohesin and CTCF. BioRxiv, 2022-03.
https://www.biorxiv.org/content/10.1101/2022.03.03.482826.abstract
* 2i; CHIR99021 and PD0325901 from Axon Medchem

Hanuscheck, N., Thalman, C., Domingues, M., Schmaul, S., Muthuraman, M., Hetsch, F., ... & Zipp, F. (2022). Interleukin-4 receptor signaling modulates neuronal network activity. Journal of Experimental Medicine219(6), e20211887.
https://rupress.org/jem/article-abstract/219/6/e20211887/213227

Sabate‐Soler, S., Nickels, S. L., Saraiva, C., Berger, E., Dubonyte, U., Barmpa, K., ... & Schwamborn, J. C. (2022). Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality. Glia70(7), 1267-1288.
https://onlinelibrary.wiley.com/doi/abs/10.1002/glia.24167

Pazur, K., Giannios, I., Lesche, M., Rodriguez-Aznar, E., & Gavalas, A. (2022). Hoxb1 regulates distinct signaling pathways in neuromesodermal and hindbrain progenitors to promote cell survival and specification. Stem Cells40(2), 175-189.
https://academic.oup.com/stmcls/article-abstract/40/2/175/6514433

Yuri, S., Murase, Y., & Isotani, A. Generation of Rat Lungs by Blastocyst Complementation in Fgfr2b-Deficient Mouse. Available at SSRN 4096295.
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4096295
* CHIR99021 and CGP77675 from Axon Medchem

Zhao, M., Ren, K., Xiong, X., Xin, Y., Zou, Y., Maynard, J. C., ... & Ruan, H. B. (2022). Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C. Immunity55(4), 623-638.
https://www.sciencedirect.com/science/article/pii/S1074761322001327

Velez, M. V. L., Neikes, H. K., Snabel, R. R., Quint, Y., Qian, C., Martens, A., ... & Vermeulen, M. (2022). ONECUT2 restricts Microfold cell numbers in the small intestine; a multi-omics study. bioRxiv, 2022-09.
https://www.biorxiv.org/content/10.1101/2022.09.01.506202v1.full

Zhang, F., Meier, A. B., Poch, C. M., Tian, Q., Engelhardt, S., Sinnecker, D., ... & Dorn, T. (2022). High-throughput optical action potential recordings in hiPSC-derived cardiomyocytes with a genetically encoded voltage indicator in the AAVS1 locus. Frontiers in Cell and Developmental Biology10.
https://mediatum.ub.tum.de/doc/1690899/document.pdf

Fagerlund, I., Dougalis, A., Shakirzyanova, A., Gómez-Budia, M., Pelkonen, A., Konttinen, H., ... & Malm, T. (2022). Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids. Cells, 11(1), 124.
https://www.mdpi.com/1430004
* CHIR99021 from Axon Medchem

Sheban, D., Shani, T., Maor, R., Aguilera-Castrejon, A., Mor, N., Oldak, B., ... & Merbl, Y. (2022). SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity. Molecular cell82(1), 106-122.
https://www.sciencedirect.com/science/article/pii/S1097276521009904?dgcid=author
*3i: CHIR99021, PD 0325901 and Y 27632 from Axon Medchem

Meier, A. B., Murthi, S. R., Rawat, H., Toepfer, C. N., Santamaria, G., Schmid, M., ... & Wolf, C. M. (2022). Cell cycle defects underlie childhood-onset cardiomyopathy associated with Noonan syndrome. Iscience25(1), 103596.
https://www.sciencedirect.com/science/article/pii/S2589004221015662
* CHIR99021 from Axon Medchem

Kaemena, D. F., Yoshihara, M., Ashmore, J., Beniazza, M., Zhao, S., Bertenstam, M., ... & Kaji, K. (2022). B1 SINE-binding ZFP266 impedes reprogramming through suppression of chromatin opening by pioneering factors. bioRxiv.
https://www.biorxiv.org/content/10.1101/2022.01.04.474927v1.full
* 2i: CHIR99021 and PD 0325901 from Axon Medchem

Pazur, K., Giannios, I., Lesche, M., Rodriguez-Aznar, E., & Gavalas, A. (2022). Hoxb1 regulates distinct signaling pathways in neuromesodermal and hindbrain progenitors to promote cell survival and specification. Stem Cells.
https://academic.oup.com/stmcls/advance-article-abstract/doi/10.1093/stmcls/sxab014/6514433

Zagare, A., Barmpa, K., Smajic, S., Smits, L. M., Grzyb, K., Grünewald, A., ... & Schwamborn, J. C. (2022). Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p. Gly2019Ser-associated gene expression. The American Journal of Human Genetics.
https://www.sciencedirect.com/science/article/pii/S000292972100464X

Sáez, M., Blassberg, R., Camacho-Aguilar, E., Siggia, E. D., Rand, D. A., & Briscoe, J. (2022). Statistically derived geometrical landscapes capture principles of decision-making dynamics during cell fate transitions. Cell Systems13(1), 12-28.
https://www.sciencedirect.com/science/article/pii/S2405471221003367
* 2i: CHIR99021 and PD 0325901 from Axon Medchem

Franck, S., Couvreu De Deckersberg, E., Bubenik, J. L., Markouli, C., Barbé, L., Allemeersch, J., ... & Karen, D. (2022). Myotonic dystrophy type 1 embryonic stem cells show decreased myogenic potential, increased CpG methylation at the DMPK locus and RNA mis-splicing. Biology open11(1), bio058978.
https://journals.biologists.com/bio/article/11/1/bio058978/273965/Myotonic-dystrophy-type-1-embryonic-stem-cells

Klemke, L., Blume, J. P., De Oliveira, T., & Schulz-Heddergott, R. (2022). Preparation and Cultivation of Colonic and Small Intestinal Murine Organoids Including Analysis of Gene Expression and Organoid Viability. Bio-protocol12(2), e4298-e4298.
https://bio-protocol.org/e4298

Yuri, S., Murase, Y., & Isotani, A. (2022). Generation of rat lungs by blastocyst complementation in Fgfr2b-deficient mouse model. bioRxiv.
https://www.biorxiv.org/content/10.1101/2022.01.05.475149v1.full

Duelen, R., Costamagna, D., Gilbert, G., De Waele, L., Goemans, N., Desloovere, K., ... & Sampaolesi, M. (2022). Human iPSC model reveals a central role for NOX4 and oxidative stress in Duchenne cardiomyopathy. Stem Cell Reports.
https://www.sciencedirect.com/science/article/pii/S2213671121006585

Ribeiro, M. C., Rivera-Arbeláez, J. M., Cofiño-Fabres, C., Schwach, V., Slaats, R. H., Den, S. A. T., ... & Passier, R. (2022). A New Versatile Platform for Assessment of Improved Cardiac Performance in Human-Engineered Heart Tissues. Journal of Personalized Medicine12(2), 214.
https://www.mdpi.com/2075-4426/12/2/214

2021 (117 citations)
Gjaltema, R. A., Schwämmle, T., Kautz, P., Robson, M., Schöpflin, R., Lustig, L. R., ... & Schulz, E. G. (2021). Distal and proximal cis-regulatory elements sense X chromosome dosage and developmental state at the Xist locus. Molecular Cell.
https://www.sciencedirect.com/science/article/pii/S109727652101025X
* 2i; CHIR99021 and PD0325901 from Axon Medchem

Mishra, S., Taelman, J., Popovic, M., Tilleman, L., Duthoo, E., Jeught, M., ... & Heindryckx, B. (2021). Activin A-derived human embryonic stem cells show increased competence to differentiate into primordial germ cell-like cells. Stem Cells39(5), 551-563.
https://academic.oup.com/stmcls/article-abstract/39/5/551/6423762

Nemoto, A., Kobayashi, R., Yoshimatsu, S., Sato, Y., Kondo, T., Yoo, A. S., ... & Okano, H. (2021). Direct neuronal reprogramming of common marmoset fibroblasts by ASCL1, microRNA-9/9*, and microRNA-124 overexpression. Cells10(1), 6.
https://www.mdpi.com/932898

Festuccia, N., Owens, N., Chervova, A., Dubois, A., & Navarro, P. (2021). The combined action of Esrrb and Nr5a2 is essential for murine naïve pluripotency. Development148(17), dev199604.
https://journals.biologists.com/dev/article-abstract/148/17/dev199604/272136
2i: CHIR99021 and PD0325901 from Axon Medchem

Di Stefano, B., & Hochedlinger, K. Reduced MEK inhibition preserves genomic stability in naïve human ES cells. Protocol Exchange, doi, 10. posted 2018, online 2021
httpikeos://assets.researchsquare.com/files/nprot-6829/v1/eb3f5184-8291-4206-8e0d-6ed902bce15f.pdf
* CHIR99021, PD 0325901, IM-12, Y 27632, Go 6983, SB 590885, WH-4-023 from Axon Medchem

Ikeo, S., Yamamoto, Y., Ikeda, K., Sone, N., Korogi, Y., Tomiyama, L., ... & Gotoh, S. (2021). Core-shell hydrogel microfiber-expanded pluripotent stem cell-derived lung progenitors applicable to lung reconstruction in vivo. Biomaterials276, 121031.
https://www.sciencedirect.com/science/article/pii/S0142961221003872

Tam, W. L., Freitas Mendes, L., Chen, X., Lesage, R., Van Hoven, I., Leysen, E., ... & Luyten, F. P. (2021). Human pluripotent stem cell-derived cartilaginous organoids promote scaffold-free healing of critical size long bone defects. Stem cell research & therapy12(1), 1-16.
* CHIR99021 and BIO from Axon Medchem
 
Bayerl, J., Ayyash, M., Shani, T., Manor, Y. S., Gafni, O., Massarwa, R., ... & Hanna, J. H. (2021). Principles of signaling pathway modulation for enhancing human naive pluripotency induction. Cell Stem Cell.
* CHIR99021 and 14i from Axon Medchem (including PD0325901, IWR1, BIR0796, Go6983, Y27632, CGP77675, RIN1, LDN193189, A83-01, SB590885, BIX02189, RU-SKI43, BIX01294.

Fischer, V., Scheer, E., Lata, E., Morlet, B., Plassard, D., Vincent, S. D., ... & Tora, L. (2021). SUPT3H-less SAGA coactivator can assemble and function without significantly perturbing RNA polymerase II transcription in mammalian cells. bioRxiv.
* 2i: CHIR99021, PD 0325901 from Axon Medchem

Zagare, A., Gobin, M., Monzel, A. S., & Schwamborn, J. C. (2021). A robust protocol for the generation of human midbrain organoids. STAR protocols2(2), 100524.
Qin, W., Ugur, E., Mulholland, C. B., Bultmann, S., Solovei, I., Modic, M., ... & Leonhardt, H. (2021). Phosphorylation of the HP1β hinge region sequesters KAP1 in heterochromatin and promotes the exit from naïve pluripotency. Nucleic acids research49(13), 7406-7423.
* 2i: CHIR99021, PD 0325901 from Axon Medchem

Hall, G. N., Tam, W. L., Andrikopoulos, K. S., Casas-Fraile, L., Voyiatzis, G. A., Geris, L., ... & Papantoniou, I. (2021). Patterned, organoid-based cartilaginous implants exhibit zone specific functionality forming osteochondral-like tissues in vivo. Biomaterials273, 120820.
Kuwata, F., Ohnishi, H., Yamamoto, N., Takezawa, T., Yamashita, M., Okuyama, H., ... & Omori, K. (2021). Transplantation of human iPS cell-derived airway cells on vitrigel membrane into rat nasal cavity. Tissue Engineering, (ja).
Rausch, C., Zhang, P., Casas-Delucchi, C. S., Daiß, J. L., Engel, C., Coster, G., ... & Cardoso, M. C. (2021). Cytosine base modifications regulate DNA duplex stability and metabolism. Nucleic acids research49(22), 12870-12894.
* 2i: CHIR99021, PD 0325901 from Axon Medchem

Giacomelli, E., Sala, L., Ward-van Oostwaard, D., & Bellin, M. (2021). Cardiac microtissues from human pluripotent stem cells recapitulate the phenotype of long-QT syndrome. Biochemical and Biophysical Research Communications572, 118-124.
Devika, A. S., Montebaur, A., Saravanan, S., Bhushan, R., Koch, F., & Sudheer, S. (2021). Human ES Cell Culture Conditions Fail to Preserve the Mouse Epiblast State. Stem cells international2021.
* 2i: CHIR99021, PD 0325901 from Axon Medchem

Yoshimatsu, S., Murakami, R., Nakajima, M., Sato, T., Kawasaki, H., & Okano, H. (2021). Establishment of an induced pluripotent stem cell line from a female domestic ferret (Mustela putorius furo) with an X chromosome instability. Stem Cell Research53, 102385.
Mishra, S., Taelman, J., Chang, Y. W., Boel, A., De Sutter, P., Heindryckx, B., & Chuva De Sousa Lopes, S. M. (2021). Sex-Specific Isolation and Propagation of Human Premeiotic Fetal Germ Cells and Germ Cell-Like Cells. Cells10(5), 1214.
Renner, H., Becker, K. J., Kagermeier, T. E., Grabos, M., Eliat, F., Günther, P., ... & Bruder, J. M. (2021). Cell-type-specific high throughput toxicity testing in human midbrain Organoids. Frontiers in molecular neuroscience14.
Salti, A., Etemad, S., Cubero, M. S., Albertini, E., Kovacs-Szalka, B., Holzknecht, M., ... & Jansen Dürr, P. (2021). High Glycolytic Activity Enhances Stem Cell Reprogramming of Fahd1-KO Mouse Embryonic Fibroblasts. Cells10(8), 2040.
Wang, F., El-Saafin, F., Ye, T., Stierle, M., Negroni, L., Durik, M., ... & Tora, L. (2021). Histone H2Bub1 deubiquitylation is essential for mouse development, but does not regulate global RNA polymerase II transcription. Cell Death & Differentiation, 1-19.
* 2i: CHIR99021, PD 0325901 from Axon Medchem

Stathakos, P., Jiménez-Moreno, N., Crompton, L. A., Nistor, P. A., Badger, J. L., Barbuti, P. A., ... & Lane, J. D. (2021). A monolayer hiPSC culture system for autophagy/mitophagy studies in human dopaminergic neurons. Autophagy17(4), 855-871.
* 2i: CHIR99021, PD 0325901 from Axon Medchem

Saraswat, D., Shayya, H. J., Polanco, J. J., Tripathi, A., Welliver, R. R., Pol, S. U., ... & Sim, F. J. (2021). Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following experimental demyelination. Nature communications12(1), 1-18.
Yoshimatsu, S., Qian, E., Sato, T., Yamamoto, M., Ishikawa, M., & Okano, H. (2021). Establishing an induced pluripotent stem cell line from neonatal common marmoset fibroblasts by an all-in-one episomal vector approach. Stem Cell Research53, 102380.
Kobayashi, T., Castillo-Venzor, A., Penfold, C. A., Morgan, M., Mizuno, N., Tang, W. W., ... & Surani, M. A. (2021). Tracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cells. Cell Reports37(2), 109812.
Breunig, M., Merkle, J., Melzer, M. K., Heller, S., Seufferlein, T., Meier, M., ... & Kleger, A. (2021). Differentiation of human pluripotent stem cells into pancreatic duct-like organoids. STAR protocols2(4), 100913.
Tong, Z., Kwak, E., Aguiar, A., Peng, B., Pouton, C. W., Voelcker, N. H., & Haynes, J. M. (2021). Compartmentalized microfluidic chambers enable long-term maintenance and communication between human pluripotent stem cell-derived forebrain and midbrain neurons. Lab on a Chip21(20), 4016-4030.
* Purmorphamine and CHIR99021 from Axon Medchem

Yoshida, J., Watanabe, H., Yamauchi, K., Nishikubo, T., Isotani, A., Ohtsuka, S., ... & Horie, K. (2021). Inhibition of N-myristoyltransferase Promotes Naive Pluripotency in Mouse and Human Pluripotent Stem Cells. bioRxiv.
* 2i: CHIR99021 and PD 0325901 from Axon Medchem

Klima, S., Suciu, I., Hoelting, L., Gutbier, S., Waldmann, T., Dietrich, D. R., & Leist, M. (2021). Examination of microcystin neurotoxicity using central and peripheral human neurons. Alternatives to Animal Experimentation: ALTEX38(1), 73-81.
Steinberg, D. J., Repudi, S., Saleem, A., Kustanovich, I., Viukov, S., Abudiab, B., ... & Aqeilan, R. I. (2021). Modeling genetic epileptic encephalopathies using brain organoids. EMBO molecular medicine13(8), e13610.
* CHIR99021, A83-01 and LDN 193189 from Axon Medchem

Zhou, D., Tan, Y., Liu, X., Tang, L., Wang, H., Shen, J., ... & Zhao, M. (2021). Patient-specific iPSC-derived endothelial cells reveal aberrant p38 MAPK signaling in atypical hemolytic uremic syndrome. Stem cell reports16(9), 2305-2319.
Campostrini, G., Meraviglia, V., Giacomelli, E., van Helden, R. W., Yiangou, L., Davis, R. P., ... & Mummery, C. L. (2021). Generation, functional analysis and applications of isogenic three-dimensional self-aggregating cardiac microtissues from human pluripotent stem cells. Nature Protocols16(4), 2213-2256.
Harberts, J., Siegmund, M., Schnelle, M., Zhang, T., Lei, Y., Yu, L., ... & Blick, R. H. (2021). Robust neuronal differentiation of human iPSC-derived neural progenitor cells cultured on densely-spaced spiky silicon nanowire arrays. Scientific reports11(1), 1-10.
Klima, S., Brüll, M., Spreng, A. S., Suciu, I., Falt, T., Schwamborn, J. C., ... & Leist, M. (2021). A human stem cell-derived test system for agents modifying neuronal N-methyl-d-aspartate-type glutamate receptor Ca 2+-signalling. Archives of toxicology95(5), 1703-1722.
Buentello, D. C., Koch, L. S., Trujillo-de Santiago, G., Alvarez, M. M., & Broersen, K. (2021). Use of standard U-bottom and V-bottom well plates to generate neuroepithelial embryoid bodies. bioRxiv.
Heller, S., Li, Z., Lin, Q., Geusz, R., Breunig, M., Hohwieler, M., ... & Costa, I. G. (2021). Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation. Communications biology4(1), 1-12.
Fabyanic, E. B., Hu, P., Qiu, Q., Wang, T., Berríos, K. N., Flournoy, J., ... & Wu, H. (2021). Quantitative single cell 5hmC sequencing reveals non-canonical gene regulation by non-CG hydroxymethylation. bioRxiv.
* 2i: CHIR99021, PD 0325901 from Axon Medchem

Duelen, R., Costamagna, D., Gilbert, G., De Waele, L., Goemans, N., Desloovere, K., ... & Sampaolesi, M. COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv.
Fischer, V., Plassard, D., Ye, T., Reina-San-Martin, B., Stierle, M., Tora, L., & Devys, D. (2021). The related coactivator complexes SAGA and ATAC control embryonic stem cell self-renewal through acetyltransferase-independent mechanisms. Cell reports36(8), 109598.
* 2i: CHIR99021 and PD 0325901 from Axon Medchem

Isermann, T., Şener, Ö. Ç., Stender, A., Klemke, L., Winkler, N., Neesse, A., ... & Schulz-Heddergott, R. (2021). Suppression of HSF1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity. Nature communications12(1), 1-17.
Zhu, S., Stanslowsky, N., Fernández-Trillo, J., Mamo, T. M., Yu, P., Kalmbach, N., ... & Viejo-Borbolla, A. (2021). Generation of hiPSC-derived low threshold mechanoreceptors containing axonal termini resembling bulbous sensory nerve endings and expressing Piezo1 and Piezo2. Stem Cell Research56, 102535.
Walter, J., Bolognin, S., Poovathingal, S. K., Magni, S., Gérard, D., Antony, P. M., ... & Schwamborn, J. C. (2021). The Parkinson’s-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1. Cell Reports37(3), 109864.
Ghelman, J., Grewing, L., Windener, F., Albrecht, S., Zarbock, A., & Kuhlmann, T. (2021). SKAP2 as a new regulator of oligodendroglial migration and myelin sheath formation. bioRxiv.
Wiedenmann, S., Breunig, M., Merkle, J., von Toerne, C., Georgiev, T., Moussus, M., ... & Meier, M. (2021). Single-cell-resolved differentiation of human induced pluripotent stem cells into pancreatic duct-like organoids on a microwell chip. Nature biomedical engineering5(8), 897-913.
Cao, B., Coelho, S., Li, J., Wang, G., & Pertsinidis, A. (2021). Volumetric interferometric lattice light-sheet imaging. Nature Biotechnology39(11), 1385-1393.
Vivas, A., van den Berg, A., Passier, R., Odijk, M., & van der Meer, A. D. (2021). Fluidic Circuit Board with Modular Sensor and Valves Enables Stand-Alone, Tubeless Microfluidic Flow Control in Organs-on-Chips. bioRxiv.
Dolde, X., Karreman, C., Wiechers, M., Schildknecht, S., & Leist, M. (2021). Profiling of Human Neural Crest Chemoattractant Activity as a Replacement of Fetal Bovine Serum for In Vitro Chemotaxis Assays. International journal of molecular sciences22(18), 10079.
Duelen, R., Costamagna, D., Gilbert, G., De Waele, L., Goemans, N., Desloovere, K., ... & Sampaolesi, M. (2021). Human iPSC-Based Model Reveals NOX4 as Therapeutic Target in Duchenne Cardiomyopathy. bioRxiv.
Scheer, E., Luo, J., Bernardini, A., Ruffenach, F., Garnier, J. M., Kolb-Cheynel, I., ... & Tora, L. (2021). TAF8 regions important for TFIID lobe B assembly or for TAF2 interactions are required for embryonic stem cell survival. Journal of Biological Chemistry297(5).
* 2i: CHIR99021 and PD 0325901 from Axon Medchem

Funa, N. S., de Lichtenberg, K. H., Hansen, M. S., van Cuyl Kuylenstierna, J., Jensen, K. B., Miao, Y., ... & Serup, P. (2021). TGF-β modulates cell fate in human ES cell-derived foregut endoderm by inhibiting multiple endogenous signaling pathways. bioRxiv.
* CHIR99021 and IWP-L6 from Axon Medchem

Desai, V. P., Chouaref, J., Wu, H., Pastor, W. A., Kan, R. L., Oey, H. M., ... & Daxinger, L. (2021). The role of MORC3 in silencing transposable elements in mouse embryonic stem cells. Epigenetics & chromatin14(1), 1-14.
* 2i: CHIR99021 + PD 0325901 from Axon Medchem

Coll, M., Ariño, S., Martínez-Sánchez, C., Garcia-Pras, E., Gallego, J., Moles, A., ... & Sancho-Bru, P. (2021). Ductular reaction promotes intrahepatic angiogenesis through Slit2-Roundabout 1 signaling. Hepatology (Baltimore, Md.).
* CHIR99021, Y 27632, A83-01 and Forskolin from Axon Medchem

Sapir, G., Steinberg, D. J., Aqeilan, R. I., & Katz-Brull, R. (2021). Real-Time Non-Invasive and Direct Determination of Lactate Dehydrogenase Activity in Cerebral Organoids—A New Method to Characterize the Metabolism of Brain Organoids?. Pharmaceuticals14(9), 878.
Harberts, J., Bours, K., Siegmund, M., Hedrich, C., Glatza, M., Schöler, H. R., ... & Blick, R. H. (2021). Culturing human iPSC-derived neural progenitor cells on nanowire arrays: mapping the impact of nanowire length and array pitch on proliferation, viability, and membrane deformation. Nanoscale13(47), 20052-20066.
Philippi, A., Heller, S., Costa, I. G., Senée, V., Breunig, M., Li, Z., ... & Kleger, A. (2021). Mutations and variants of ONECUT1 in diabetes. Nature Medicine27(11), 1928-1940.
萩原玲子. (2021). Generation of metabolically functional hepatocyte-like cells from dedifferentiated fat cells by Foxa2, Hnf4a, and Sall1 transduction.
Jansch, C. (2021). Effects of SLC2A3 copy number variants on neurodevelopment and glucose metabolism in ADHD patient-specific neurons (Doctoral dissertation, Universität Würzburg).
Wiesinger, A., Li, J., Fokkert, L. J., Bakker, P., Verkerk, A. O., Christoffels, V. M., ... & Devalla, H. D. (2021). A single cell transcriptional roadmap for human pacemaker cell differentiation. bioRxiv.
Cano Ballesteros, S. (2021). FSP1/S100A4 delineates distinct cardiac cell populations.
Grandela, C., Blanch-Asensio, A., Brandao, K. O., de Korte, T., Yiangou, L., Mol, M. P., ... & Davis, R. P. (2021). STRAIGHT-IN: A platform for high-throughput targeting of large DNA payloads into human pluripotent stem cells. bioRxiv.
Klein, T. (2021). Establishing an in vitro disease model for Fabry Disease using patient specific induced pluripotent stem cell-derived sensory neurons (Doctoral dissertation, Universität Würzburg).
Festuccia, N., Owens, N., Chervova, A., Dubois, A., & Navarro, P. (2021). The combined action of Esrrb and Nr5a2 is essential for murine naïve pluripotency. Development148(17), dev199604.
Vivas, A., IJspeert, C., Pan, J. Y., Vermeul, K., van den Berg, A., Passier, R., ... & van der Meer, A. D. (2021). Generation and Culture of Cardiac Microtissues in a Microfluidic Chip with a Reversible Open Top Enables Electrical Pacing, Dynamic Drug Dosing and Endothelial Cell Co-Culture. bioRxiv.
van Neerven, S. M., de Groot, N. E., Nijman, L. E., Scicluna, B. P., van Driel, M. S., Lecca, M. C., ... & Vermeulen, L. (2021). Apc-mutant cells act as supercompetitors in intestinal tumour initiation. Nature594(7863), 436-441.
Klima, S. (2021). Developmental neurotoxicity in a human model system (Doctoral dissertation).
Reeh, L. (2021). Immunmodulatorische Effekte CD44-positiver Gefäßwand-residenter Stamm-und Vorläuferzellen im myokardialen Gewebe (Doctoral dissertation, Universität Würzburg).
Preciat, G., Moreno, E. L., Wegrzyn, A. B., Willacey, C. C., Modamio, J., Monteiro, F. L., ... & Fleming, R. M. (2021). Mechanistic model-driven exometabolomic characterisation of human dopaminergic neuronal metabolism. bioRxiv.
Shiozawa, S., & Okano, H. Sho Yoshimatsu,* Mayutaka Nakajima, Aozora Iguchi, 4 Tsukasa Sanosaka, Tsukika Sato, Mari Nakamura, Ryusuke Nakajima, 3 Eri Arai, 5 Mitsuru Ishikawa, Kent Imaizumi, Hirotaka Watanabe, Junko Okahara, 3, 6 Toshiaki Noce, 3 Yuta Takeda, 3 Erika Sasaki, 3, 6 Rüdiger Behr, 7, 8 Kazuya Edamura, 4.
Morpurgo, E. NECAB2/MitoNEET represents an alternative activity-triggered mitochondrial quality control system.
Löw, K. (2021). Identifizierung und Charakterisierung koronarer Gefäßwand-residenter Stammzellen (Doctoral dissertation, Universität Würzburg).
Rang, F. J., de Luca, K. L., de Vries, S. S., Valdes-Quezada, C., Boele, E., Nguyen, P. D., ... & Kind, J. (2021). Single-cell profiling of transcriptome and histone modifications with EpiDamID. bioRxiv.
Dolde, X. (2021). Novel neural crest cell function assays to evaluate developmental toxicity hazards (Doctoral dissertation).
Slaats, R. H. MODELLING THE HUMAN HEART.
Dambacher, H. (2021). Die Etablierung des CRISPR/Cas9-Systems in humanen induzierten pluripotenten Stammzellen zur Untersuchung der Funktion des Kanalproteins Connexin 43 in der Embryonalentwicklung (Doctoral dissertation, Universität Würzburg).
持田泰佑. (2021). 消化管と膵臓の内分泌機能に着目した糖尿病および肥満の予防・改善に関する研究 (Doctoral dissertation, 北海道大学).
Zagare, A., Gobin, M., Monzel, A. S., & Schwamborn, J. C. (2021). A robust protocol for the generation of human midbrain organoids. STAR protocols2(2), 100524.
Genolet Alberdi, O. (2021). Identification of X-chromosomal genes that drive global X-dosage effects in mammals(Doctoral dissertation).
* 2i: CHIR99021 and PD 0325901 from Axon Medchem
 
Kobayashi, T., Goto, T., Oikawa, M., Sanbo, M., Yoshida, F., Terada, R., ... & Hirabayashi, M. (2021). Blastocyst complementation using Prdm14-deficient rats enables efficient germline transmission and generation of functional mouse spermatids in rats. Nature communications12(1), 1-10.
* 2i: CHIR99021 + PD 0325901 from Axon Medchem

Gonçalves, C. A., Larsen, M., Jung, S., Stratmann, J., Nakamura, A., Leuschner, M., ... & Grapin-Botton, A. (2021). A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansion. Nature communications12(1), 1-17.
Schütz, A., Richter, C., Weissgerber, P., Tsvilovskyy, V., Hesse, M., Ottenheijm, R., ... & Freichel, M. (2021). Trophectoderm cell failure leads to peri-implantation lethality in Trpm7-deficient mouse embryos. Cell Reports37(3), 109851.
* 2i: CHIR99021 + PD 0325901 from Axon Medchem

Bruzelius, A., Kidnapillai, S., Drouin-Ouellet, J., Stoker, T., Barker, R. A., & Rylander Ottosson, D. (2021). Reprogramming human adult fibroblasts into GABAergic interneurons. Cells10(12), 3450.
* CHIR99021 + PD 0325901 + LDN 193189 from Axon Medchem

Pantier, R., Chhatbar, K., Quante, T., Skourti-Stathaki, K., Cholewa-Waclaw, J., Alston, G., ... & Bird, A. (2021). SALL4 controls cell fate in response to DNA base composition. Molecular cell81(4), 845-858.
* 2i: CHIR99021 + PD 0325901 from Axon Medchem

Zuin, J., Roth, G., Zhan, Y., Cramard, J., Redolfi, J., Piskadlo, E., ... & Giorgetti, L. (2021). Nonlinear control of transcription through enhancer-promoter interactions. bioRxiv.
* 2i: CHIR99021 + PD 0325901 from Axon Medchem
 
Xiong, M., Tao, Y., Gao, Q., Feng, B., Yan, W., Zhou, Y., ... & Zhang, S. C. (2021). Human stem cell-derived neurons repair circuits and restore neural function. Cell Stem Cell28(1), 112-126.
Merlevede, A., Legault, E. M., Drugge, V., Barker, R. A., Drouin-Ouellet, J., & Olariu, V. (2021). A quantitative model of cellular decision making in direct neuronal reprogramming. Scientific reports11(1), 1-18.
* CHIR99021 + SB 431542 + LDN 193189 from Axon Medchem

Yin, H., Wei, C., & Lee, J. T. (2021). Revisiting the consequences of deleting the X inactivation center. Proceedings of the National Academy of Sciences118(25).
* 2i: CHIR99021 + PD 0325901 from Axon Medchem

Drouin-Ouellet, J., Pircs, K., Legault, E. M., Birtele, M., Nilsson, F., Shrigley, S., ... & Parmar, M. (2021). Age-related pathological impairments in induced neurons derived from patients with idiopathic Parkinson's disease. bioRxiv.
* CHIR99021 + SB 431542 + LDN 193189 from Axon Medchem

Saez, M., Blassberg, R., Camacho-Aguilar, E., Siggia, E. D., Rand, D. A., & Briscoe, J. (2021). A quantitative landscape of cell fate transitions identifies principles of cellular decision-making. bioRxiv.
Exelby, K., Herrera-Delgado, E., Perez, L. G., Perez-Carrasco, R., Sagner, A., Metzis, V., ... & Briscoe, J. (2021). Precision of tissue patterning is controlled by dynamical properties of gene regulatory networks. Development148(4), dev197566.
Sagner, A., Zhang, I., Watson, T., Lazaro, J., Melchionda, M., & Briscoe, J. (2021). A shared transcriptional code orchestrates temporal patterning of the central nervous system. PLoS biology19(11), e3001450.
Lagerwall, J. (2021). Autophagy and antipsychotic treatment response: Characterising a potential relationship in a neuropsychiatric disorders context.
CHIR99021 + SB 431542 + LDN 193189 from Axon Medchem

Bernad, R., Lynch, C. J., Urdinguio, R. G., Stephan-Otto Attolini, C., Fraga, M. F., & Serrano, M. (2021). Stability of Imprinting and Differentiation Capacity in Naïve Human Cells Induced by Chemical Inhibition of CDK8 and CDK19. Cells10(4), 876.
https://www.mdpi.com/2073-4409/10/4/876/htm
* 2i: CHIR99021 + PD 0325901 from Axon Medchem

Martinez-Val, A., Lynch, C. J., Calvo, I., Ximénez-Embún, P., Garcia, F., Zarzuela, E., ... & Munoz, J. (2021). Dissection of two routes to naïve pluripotency using different kinase inhibitors. Nature Communications12(1), 1-16.
https://www.nature.com/articles/s41467-021-22181-5
* 2i: CHIR99021 and PD 0325901 from Axon Medchem

Fischer, V., Plassard, D., Ye, T., San Martin, B. R., Stierle, M., Tora, L., & Devys, D. Two Related Coactivator Complexes SAGA and ATAC Control Embryonic Stem Cell Self-Renewal Through Two Different Acetyltransferase-Independent Mechanisms. Available at SSRN 3782006.
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3782006
* 2i: CHIR99021 + PD 0325901 from Axon Medchem

Genolet, O., Monaco, A. A., Dunkel, I., Boettcher, M., & Schulz, E. G. (2021). Identification of X-chromosomal genes that drive sex differences in embryonic stem cells through a hierarchical CRISPR screening approach. Genome Biology22(1), 1-41.
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-021-02321-2
* 2i: CHIR99021 + PD 0325901 from Axon Medchem

Kanagaki, S., Ikeo, S., Suezawa, T., Yamamoto, Y., Seki, M., Hirai, T., ... & Gotoh, S. (2021). Directed induction of alveolar type I cells derived from pluripotent stem cells via Wnt signaling inhibition. Stem Cells, 39(2), 156-169.
https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/stem.3302

Müller, J. A., Groß, R., Conzelmann, C., Krüger, J., Merle, U., Steinhart, J., ... & Kleger, A. (2021). SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas. Nature Metabolism, 1-17.
https://www.nature.com/articles/s42255-021-00347-1?elqTrackId=e0563488ddb44e0e89d32dfd961b20c6

Nemoto, A., Kobayashi, R., Yoshimatsu, S., Sato, Y., Kondo, T., Yoo, A. S., ... & Okano, H. (2021). Direct Neuronal Reprogramming of Common Marmoset Fibroblasts by ASCL1, microRNA-9/9*, and microRNA-124 Overexpression. Cells, 10(1), 6.
https://www.mdpi.com/2073-4409/10/1/6

Spijkers, X. M., Pasteuning-Vuhman, S., Dorleijn, J. C., Vulto, P., Wevers, N. R., & Pasterkamp, R. J. (2021). A directional 3D neurite outgrowth model for studying motor axon biology and disease. Scientific reports, 11(1), 1-15.
https://www.nature.com/articles/s41598-021-81335-z?elqTrackId=89cdfe62350e4404b93097e862af6ee2

Bartoschek, M. D., Ugur, E., Nguyen, T. A., Rodschinka, G., Wierer, M., Lang, K., & Bultmann, S. (2021). Identification of permissive amber suppression sites for efficient non-canonical amino acid incorporation in mammalian cells. Nucleic Acids Research.
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkab132/6158120?login=true
* 2i: CHIR99021 and PD 0325901 from Axon Medchem

Qin, W., Stengl, A., Ugur, E., Leidescher, S., Ryan, J., Cardoso, M. C., & Leonhardt, H. (2021). HP1β carries an acidic linker domain and requires H3K9me3 for phase separation. Nucleus, 12(1), 44-57.
https://www.tandfonline.com/doi/full/10.1080/19491034.2021.1889858
* 2i: CHIR99021 and PD 0325901 from Axon Medchem

Manstein, F., Ullmann, K., Kropp, C., Halloin, C., Triebert, W., Franke, A., ... & Zweigerdt, R. (2021). High density bioprocessing of human pluripotent stem cells by metabolic control and in silico modeling. Stem cells translational medicine.
https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/sctm.20-0453
* CHIR99021 and SB 431542 from Axon Medchem

Mishra, S., Taelman, J., Popovic, M., Tilleman, L., Duthoo, E., Van der Jeught, M., ... & Heindryckx, B. (2021). Activin A‐derived human embryonic stem cells show increased competence to differentiate into primordial germ cell‐like cells. Stem Cells.
https://stemcellsjournals.onlinelibrary.wiley.com/doi/abs/10.1002/stem.3335

Yoshimatsu, M., Ohnishi, H., Zhao, C., Hayashi, Y., Kuwata, F., Okuyama, H., ... & Omori, K. (2021). In vivo regeneration of rat laryngeal cartilage with mesenchymal stem cells derived from human induced pluripotent stem cells via neural crest cells. Stem cell research, 102233.
https://www.sciencedirect.com/science/article/pii/S1873506121000799

Lee, M. H., Thomas, J. L., Su, Z. L., Yeh, W. K., Monzel, A. S., Bolognin, S., ... & Lin, H. Y. (2021). Epitope imprinting of alpha-synuclein for sensing in Parkinson's brain organoid culture medium. Biosensors and Bioelectronics, 175, 112852.
https://www.sciencedirect.com/science/article/abs/pii/S0956566320308381

Mus, L. M., Van Haver, S., Popovic, M., Trypsteen, W., Lefever, S., Zeltner, N., ... & Speleman, F. (2021). Recurrent chromosomal imbalances provide selective advantage to human embryonic stem cells under enhanced replicative stress conditions. Genes, Chromosomes and Cancer, 60(4), 272-281.
https://onlinelibrary.wiley.com/doi/abs/10.1002/gcc.22931

Zanetti, C., Spitz, S., Berger, E., Bolognin, S., Smits, L., Crepaz, P., ... & Ertl, P. (2021). Monitoring the neurotransmitter release of human midbrain organoids using a redox cycling microsensor as a novel tool for personalized Parkinson’s disease modeling and drug screening. Analyst.
https://pubs.rsc.org/en/content/articlehtml/2021/an/d0an02206c

Chang, W. F., Peng, M., Hsu, J., Xu, J., Cho, H. C., Hsieh-Li, H. M., ... & Sung, L. Y. (2021). Effects of Survival Motor Neuron Protein on Germ Cell Development in Mouse and Human. International Journal of Molecular Sciences, 22(2), 661.
https://www.mdpi.com/1422-0067/22/2/661
* 2i: CHIR99021 and PD 0325901 from Axon Medchem

Jansch, C., Ziegler, G. C., Forero, A., Gredy, S., Wäldchen, S., Vitale, M. R., ... & Lesch, K. P. (2021). Serotonin-specific neurons differentiated from human iPSCs form distinct subtypes with synaptic protein assembly. Journal of Neural Transmission, 1-17.
https://link.springer.com/article/10.1007/s00702-021-02303-5

Watanabe, M., Yamada, Y., Kurumida, Y., Kameda, T., Sukeno, M., Iizuka-Ohashi, M., ... & Mutoh, M. (2021). Rabdosianone I, a Bitter Diterpene from an Oriental Herb, Suppresses Thymidylate Synthase Expression by Directly Binding to ANT2 and PHB2. Cancers, 13(5), 982.
https://www.mdpi.com/2072-6694/13/5/982/htm

Wang, F., El-Saafin, F., Ye, T., Stierle, M., Negroni, L., Durik, M., ... & Tora, L. (2021). Histone H2Bub1 deubiquitylation is essential for mouse development, but does not regulate global RNA polymerase II transcription. bioRxiv.
https://www.biorxiv.org/content/10.1101/2021.02.23.432458v1.abstract
* 2i: CHIR99021 and PD 0325901 from Axon Medchem

Fischer, V., Plassard, D., Ye, T., San Martin, B. R., Stierle, M., Tora, L., & Devys, D. Two Related Coactivator Complexes SAGA and ATAC Control Embryonic Stem Cell Self-Renewal Through Two Different Acetyltransferase-Independent Mechanisms. Available at SSRN 3782006.
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3782006
* 2i: CHIR99021 and PD 0325901 from Axon Medchem

Mira-Bontenbal, H., Tan, B., Gontan, C., Goossens, S., Boers, R. G., Boers, J. B., ... & Gribnau, J. M. (2021). Genetic and epigenetic determinants of reactivation of Mecp2 and the inactive X chromosome in neural stem cells. bioRxiv.
https://www.biorxiv.org/content/10.1101/2021.02.25.432827v1.full

Klein, T. (2021). Establishing an in vitro disease model for Fabry Disease using patient specific induced pluripotent stem cell-derived sensory neurons (Doctoral dissertation, Universität Würzburg).
https://opus.bibliothek.uni-wuerzburg.de/opus4-wuerzburg/frontdoor/deliver/index/docId/19970/file/Klein_Thomas_iPSC_Dissertation.pdf

Mitsunaga, S., Shioda, K., Hanna, J. H., Isselbacher, K. J., & Shioda, T. (2021). Production and Analysis of Human Primordial Germ Cell–Like Cells. In Testicular Germ Cell Tumors (pp. 125-145). Humana, New York, NY.
https://link.springer.com/protocol/10.1007/978-1-0716-0860-9_10

Kanagaki, S., Suezawa, T., Moriguchi, K., Nakao, K., Toyomoto, M., Yamamoto, Y., ... & Gotoh, S. (2021). Hydroxypropyl cyclodextrin improves amiodarone-induced aberrant lipid homeostasis of alveolar cells. American Journal of Respiratory Cell and Molecular Biology, (ja).
https://onlinelibrary.wiley.com/doi/abs/10.1111/gtc.12736

2020 (105 citations)
Vered, I. (2020). Analysis of translesion DNA synthesis in embryonic stem cells (Doctoral dissertation, The Weizmann Institute of Science).
Analysis of translesion DNA synthesis in embryonic stem cells
* 2i: CHIR99021 + PD 0325901 from Axon Medchem

Han, B. Y., Seah, M. K., Brooks, I. R., Quek, D. H., Huxley, D. R., Foo, C. S., ... & Guccione, E. (2020). Global translation during early development depends on the essential transcription factor PRDM10. Nature communications, 11(1), 1-14.
Global translation during early development depends on the essential transcription factor PRDM10
* 2i: CHIR99021 + PD 0325901 from Axon Medchem

Ma, H., Hayama, T., Van Dyken, C., Darby, H., Koski, A., Lee, Y., ... & Mitalipov, S. (2020). Deleterious mtDNA mutations are common in mature oocytes. Biology of reproduction102(3), 607-619.
https://academic.oup.com/biolreprod/article/102/3/607/5588758?login=true
* 2i: CHIR99021 + PD 0325901 from Axon

Posfai, E., Schell, J. P., Janiszewski, A., Rovic, I., Murray, A., Bradshaw, B., ... & Rossant, J. (2020). Defining totipotency using criteria of increasing stringency. BioRxiv.
https://www.biorxiv.org/content/10.1101/2020.03.02.972893v1.full
* 2i: CHIR99021 + PD 0325901 from Axon

Pacini, G., Dunkel, I., Mages, N., Mutzel, V., Timmermann, B., Marsico, A., & Schulz, E. G. (2020). Integrated analysis of Xist upregulation and gene silencing at the onset of random X-chromosome inactivation at high temporal and allelic resolution. bioRxiv.
https://www.biorxiv.org/content/10.1101/2020.07.20.211573v1.full
* 2i: CHIR99021 + PD 0325901 from Axon Medchem

Lynch, C. J., Bernad, R., Martínez-Val, A., Shahbazi, M. N., Nóbrega-Pereira, S., Calvo, I., ... & Serrano, M. (2020). Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases. Nature Cell Biology, 22(10), 1223-1238.
https://www.nature.com/articles/s41556-020-0573-1
* CHIR99021, PD 0325901 and BIRB 796 from Axon Medchem

Kong, J. H., Young, C. B., Pusapati, G. V., Patel, C. B., Ho, S., Krishnan, A., ... & Rohatgi, R. (2020). A membrane-tethered ubiquitination pathway regulates Hedgehog signaling and heart development. Developmental Cell, 55(4), 432-449.
* CHIR99021 and PD 98059 from Axon Medchem

Sato, T., Ishikawa, S., Asano, J., Yamamoto, H., Fujii, M., Sato, T., ... & Ohteki, T. (2020). Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages. Nature Cell Biology, 22(8), 919-926.

Neagu, A., van Genderen, E., Escudero, I., Verwegen, L., Kurek, D., Lehmann, J., ... & Ten Berge, D. (2020). In vitro capture and characterization of embryonic rosette-stage pluripotency between naive and primed states. Nature cell biology, 22(5), 534-545.
https://www.nature.com/articles/s41556-020-0508-x

Ma, B., Trieu, T. J., Habib, S. J., & Chen, X. (2020). Protocol for Establishing Mouse Embryonic Stem Cells to Study Histone Inheritance Pattern at Single-Cell Resolution. STAR protocols, 1(3), 100178.
https://www.sciencedirect.com/science/article/pii/S2666166720301659
* 2i: CHIR99021 and PD 0325901 from Axon Medchem

Castel, G., Meistermann, D., Bretin, B., Firmin, J., Blin, J., Loubersac, S., ... & David, L. (2020). Induction of Human Trophoblast Stem Cells from Somatic Cells and Pluripotent Stem Cells. Cell Reports, 33(8), 108419.
https://www.sciencedirect.com/science/article/pii/S221112472031408X
* 8 inhibitors are from Axon Medchem, including CHIR99021, PD 0325901, Y 27632, IWR-1, A83-01, SB4 31542, Go 6983, Forskolin.

Dries, R., Stryjewska, A., Coddens, K., Okawa, S., Notelaers, T., Birkhoff, J., ... & Huylebroeck, D. (2020). Integrative and perturbation‐based analysis of the transcriptional dynamics of TGFβ/BMP system components in transition from embryonic stem cells to neural progenitors. Stem Cells, 38(2), 202-217.
https://stemcellsjournals.onlinelibrary.wiley.com/doi/abs/10.1002/stem.3111
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Kuo, Y. C., Hsu, C. C., & Rajesh, R. (2020). iPSCs-laden GDF8-grafted aldehyde hyaluronic acid-polyacrylamide inverted colloidal crystal constructs with controlled release of CHIR99021 and retinoic acid to generate insulin-producing cells. Journal of the Taiwan Institute of Chemical Engineers, 116, 223-237.
https://www.sciencedirect.com/science/article/pii/S1876107020303412

Shiozawa, S., Nakajima, M., Okahara, J., Kuortaki, Y., Kisa, F., Yoshimatsu, S., ... & Okano, H. (2020). Primed to naïve-like conversion of the common marmoset embryonic stem cells. Stem cells and development, 29(12), 761-773.
https://www.liebertpub.com/doi/abs/10.1089/scd.2019.0259

Sangokoya, C., & Blelloch, R. (2020). MicroRNA-dependent inhibition of PFN2 orchestrates ERK activation and pluripotent state transitions by regulating endocytosis. Proceedings of the National Academy of Sciences, 117(34), 20625-20635.
https://www.pnas.org/content/117/34/20625.full
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Stathakos, P., Jiménez-Moreno, N., Crompton, L. A., Nistor, P. A., Badger, J. L., Barbuti, P. A., ... & Lane, J. D. (2020). A monolayer hiPSC culture system for autophagy/mitophagy studies in human dopaminergic neurons. Autophagy, 1-17.
https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1739441
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Postlmayr, A., Dumeau, C. E., & Wutz, A. (2020). Cdk8 is required for establishment of H3K27me3 and gene repression by Xist and mouse development. Development, 147(11).
https://dev.biologists.org/content/147/11/dev175141.full
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Lee, M. H., Thomas, J. L., Su, Z. L., Yeh, W. K., Monzel, A. S., Bolognin, S., ... & Lin, H. Y. (2020). Epitope imprinting of alpha-synuclein for sensing in Parkinson's brain organoid culture medium. Biosensors and Bioelectronics, 112852.
https://www.sciencedirect.com/science/article/abs/pii/S0956566320308381

Qiu, Q., Hu, P., Qiu, X., Govek, K. W., Cámara, P. G., & Wu, H. (2020). Massively parallel and time-resolved RNA sequencing in single cells with scNT-seq. Nature methods, 17(10), 991-1001.
https://www.nature.com/articles/s41592-020-0935-4
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Schruf, E., Schroeder, V., Le, H. Q., Schönberger, T., Raedel, D., Stewart, E. L., ... & Garnett, J. P. (2020). Recapitulating idiopathic pulmonary fibrosis related alveolar epithelial dysfunction in a human iPSC‐derived air‐liquid interface model. The FASEB Journal, 34(6), 7825-7846.
https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fj.201902926R

Castel, G., Meistermann, D., Bretin, B., Firmin, J., Justine, B. L. I. N., Loubersac, S., ... & David, L. (2020). Generation of human induced trophoblast stem cells. bioRxiv.
https://www.biorxiv.org/content/10.1101/2020.09.15.298257v1.full
* 5i: CHIR99021, PD0325901, Y27632, PD173074 from Axon Medchem

Yoshimatsu, M., Ohnishi, H., Zhao, C., Hayashi, Y., Kuwata, F., Kaba, S., ... & Omori, K. In Vivo Regeneration of Rat Laryngeal Cartilage with Mesenchymal Stem Cells Derived from Human Induced Pluripotent Stem Cells Via Neural Crest Cells. Available at SSRN 3733569.
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3733569

Luo, X., van der Veer, B. K., Sun, L., Bartoccetti, M., Boretto, M., Vankelecom, H., ... & Koh, K. P. (2020). Coordination of germ layer lineage choice by TET1 during primed pluripotency. Genes & development, 34(7-8), 598-618.
http://genesdev.cshlp.org/content/34/7-8/598.full
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Giacomelli, E., Meraviglia, V., Campostrini, G., Cochrane, A., Cao, X., van Helden, R. W., ... & Mummery, C. L. (2020). Human-iPSC-derived cardiac stromal cells enhance maturation in 3D cardiac microtissues and reveal non-cardiomyocyte contributions to heart disease. Cell Stem Cell, 26(6), 862-879.
https://www.sciencedirect.com/science/article/pii/S1934590920302022

Yamanaka, Y., Uemura, M., & Alev, C. (2020). Stepwise in vitro induction of human somitic mesoderm and its derivatives.
https://www.researchsquare.com/article/pex-827/v1.pdf

Harberts, J., Kusch, M., O’Sullivan, J., Zierold, R., & Blick, R. H. (2020). A Temperature-Controlled Patch Clamp Platform Demonstrated on Jurkat T Lymphocytes and Human Induced Pluripotent Stem Cell-Derived Neurons. Bioengineering, 7(2), 46.
https://www.mdpi.com/2306-5354/7/2/46

Hagiwara, R., Oki, Y., Matsumaru, T., Ibayashi, S., & Kano, K. (2020). Generation of metabolically functional hepatocyte‐like cells from dedifferentiated fat cells by Foxa2, Hnf4a and Sall1 transduction. Genes to Cells, 25(12), 811-824.
https://onlinelibrary.wiley.com/doi/abs/10.1111/gtc.12814

Ribeiro, M. C., Slaats, R. H., Schwach, V., Rivera-Arbelaez, J. M., Tertoolen, L. G., Van Meer, B. J., ... & Passier, R. (2020). A cardiomyocyte show of force: A fluorescent alpha-actinin reporter line sheds light on human cardiomyocyte contractility versus substrate stiffness. Journal of molecular and cellular cardiology, 141, 54-64.
https://www.sciencedirect.com/science/article/pii/S0022282820300699

Yamamoto, Y., Korogi, Y., Hirai, T., & Gotoh, S. (2020). A method of generating alveolar organoids using human pluripotent stem cells. In Methods in Cell Biology (Vol. 159, pp. 115-141). Academic Press.
https://www.sciencedirect.com/science/article/pii/S0091679X20300108

Bayerl, J., Ayyash, M., Shani, T., Manor, Y., Gafni, O., Kalma, Y., ... & Hanna, J. H. (2020). Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naïve Pluripotency. bioRxiv.
https://www.biorxiv.org/content/10.1101/2020.05.23.112433v1.full
* CHIR99021, PD 0325901, IWR-1, XAV 939, BIRB0796, Go6983, Y27632, CGP77675, LDN193189, A83-01, DBZ, SB590885, BIX02189, RU-SKI43, BIX-02194

Bollmanna, E., Schreibera, J. A., Rittera, N., Peischarda, S., Hoa, H. T., Wünschb, B., ... & Seebohma, G. (2020). Stilbenedisulfonic Acid (DIDS) Modulates the Activity of KCNQ1/KCNE1 Channels by an Interaction with the Central Pore Region. Cell Physiol Biochem, 54, 321-332.
https://www.researchgate.net/profile/Julian_Schreiber/publication/340512366_44'-Diisothiocyanato-22'-Stilbenedisulfonic_Acid_DIDS_Modulates_the_Activity_of_KCNQ1KCNE1_Channels_by_an_Interaction_with_the_Central_Pore_Region/links/5ea126da458515ec3aff263c/4-4-Diisothiocyanato-2-2-Stilbenedisulfonic-Acid-DIDS-Modulates-the-Activity-of-KCNQ1-KCNE1-Channels-by-an-Interaction-with-the-Central-Pore-Region.pdf

Kane, K. I., Jarazo, J., Moreno, E. L., Fleming, R. M., & Schwamborn, J. C. (2020). Passive controlled flow for Parkinson's disease neuronal cell culture in 3D microfluidic devices. Organs-on-a-Chip, 2, 100005.
https://www.sciencedirect.com/science/article/pii/S2666102020300057

Salzberg, Y., Pechuk, V., Gat, A., Setty, H., Sela, S., & Oren-Suissa, M. (2020). Synaptic protein degradation controls sexually dimorphic circuits through regulation of DCC/UNC-40. Current Biology, 30(21), 4128-4141.
https://www.sciencedirect.com/science/article/pii/S0960982220311568

Bustos, F., Segarra-Fas, A., Nardocci, G., Cassidy, A., Antico, O., Davidson, L., ... & Findlay, G. M. (2020). Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling. Developmental cell, 55(5), 629-647.
https://www.sciencedirect.com/science/article/pii/S1534580720307577
* CHIR99021, PD0325901 and SPHINX31 from Axon Medchem

Steinberg, D. J., Saleem, A., Repudi, S. R., Banne, E., Mahajnah, M., Hanna, J. H., ... & Aqeilan, R. I. (2020). Modeling Genetic Epileptic Encephalopathies using Brain Organoids. bioRxiv.
https://www.biorxiv.org/content/10.1101/2020.08.23.263236v1.full
* CHIR99021, LDN193189, A83-01 from Axon Medchem

Vila-Cejudo, M., Alonso-Alonso, S., Pujol, A., Santaló, J., & Ibáñez, E. (2020). Wnt pathway modulation generates blastomere-derived mouse embryonic stem cells with different pluripotency features. Journal of Assisted Reproduction and Genetics, 37(12), 2967-2979.
https://link.springer.com/article/10.1007/s10815-020-01964-7
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Alendar, A., Lambooij, J. P., Bhaskaran, R., Lancini, C., Song, J. Y., van Vugt, H., ... & Berns, A. (2020). Gene expression regulation by the Chromodomain helicase DNA-binding protein 9 (CHD9) chromatin remodeler is dispensable for murine development. PloS one, 15(5), e0233394.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233394
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Weinberger, L. (2020). Characterization of human naive pluripotent stem cells and their differentiation to Primordial Germ Cells (Doctoral dissertation, The Weizmann Institute of Science).
https://weizmann.esploro.exlibrisgroup.com/view/delivery/972WIS_INST/1274955990003596/1374919490003596
* CHIR99021, PD0325901, SB202190, BIRB796, Y27632, CGP77675 from Axon Medchem

Ma, B., Trieu, T. J., Cheng, J., Zhou, S., Tang, Q., Xie, J., ... & Chen, X. (2020). Differential histone distribution patterns in induced asymmetrically dividing mouse embryonic stem cells. Cell Reports, 32(6), 108003.
https://www.sciencedirect.com/science/article/pii/S2211124720309888
*2i: CHIR99021 and PD0325901 from Axon Medchem

Klima, S., Suciu, I., Hoelting, L., Gutbier, S., Waldmann, T., Dietrich, D. R., & Leist, M. (2020). Examination of microcystin neurotoxicity using central and peripheral human neurons. Alternatives to Animal Experimentation: ALTEX.
http://kops.uni-konstanz.de/handle/123456789/50031

Schenke, M., Schjeide, B. M., Püschel, G. P., & Seeger, B. (2020). Analysis of Motor Neurons Differentiated from Human Induced Pluripotent Stem Cells for the Use in Cell-Based Botulinum Neurotoxin Activity Assays. Toxins, 12(5), 276.
https://www.mdpi.com/2072-6651/12/5/276/htm

Nesterenko, Y., Dolde, X., Leist, M., & Mayans, O. (2020). Strategy to replace animal-derived ECM by a modular and highly defined matrix. Alternatives to Animal Experimentation: ALTEX, 37(3).
http://kops.uni-konstanz.de/handle/123456789/49891

Heß, K., Starost, L., Kieran, N. W., Thomas, C., Vincenten, M. C., Antel, J., ... & Kuhlmann, T. (2020). Lesion stage-dependent causes for impaired remyelination in MS. Acta neuropathologica, 140(3), 359-375.
https://link.springer.com/article/10.1007/s00401-020-02189-9

Kamiya, D., Takenaka-Ninagawa, N., Motoike, S., Kajiya, M., Akaboshi, T., Zhao, C., ... & Ikeya, M. Induction of Functional Mesenchymal Stem/Stromal Cells from Human iPCs Via a Neural Crest Cell Lineage Under Xeno-Free Conditions. Stromal Cells from Human iPCs Via a Neural Crest Cell Lineage Under Xeno-Free Conditions.
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3741231

Minamide, K., Sato, T., Nakanishi, Y., Ohno, H., Kato, T., Asano, J., & Ohteki, T. (2020). IRF2 maintains the stemness of colonic stem cells by limiting physiological stress from interferon. Scientific reports, 10(1), 1-12.
https://www.nature.com/articles/s41598-020-71633-3?elqTrackId=5f68eaf2a3044295b9a1caad4716bf51

Lasman, L., Krupalnik, V., Viukov, S., Mor, N., Aguilera-Castrejon, A., Schneir, D., ... & Hanna, J. H. (2020). Context-dependent functional compensation between Ythdf m6A reader proteins. Genes & development, 34(19-20), 1373-1391.
https://www.biorxiv.org/content/biorxiv/early/2020/06/03/2020.06.03.131441.full.pdf
* 2i from Axon Medchem

Kano, M., Takanashi, M., Oyama, G., Yoritaka, A., Hatano, T., Shiba-Fukushima, K., ... & Hattori, N. (2020). Reduced astrocytic reactivity in human brains and midbrain organoids with PRKN mutations. npj Parkinson's Disease, 6(1), 1-9.
https://www.nature.com/articles/s41531-020-00137-8

Starost, L., Lindner, M., Herold, M., Xu, Y. K. T., Drexler, H. C., Heß, K., ... & Kuhlmann, T. (2020). Extrinsic immune cell-derived, but not intrinsic oligodendroglial factors contribute to oligodendroglial differentiation block in multiple sclerosis. Acta neuropathologica, 140(5), 715-736.
https://link.springer.com/article/10.1007/s00401-020-02217-8

Gafni, O. (2020). Delineating routes and applications of naive pluripotency (Doctoral dissertation, The Weizmann Institute of Science).
https://weizmann.esploro.exlibrisgroup.com/view/delivery/972WIS_INST/1275016610003596/1375015210003596
* CHIR99021, PD0325901, SB201920, Y27632, BIRB796 from Axon Medchem

Mulholland, C. B., Traube, F. R., Ugur, E., Parsa, E., Eckl, E. M., Schönung, M., ... & Bultmann, S. (2020). Distinct and stage-specific contributions of TET1 and TET2 to stepwise cytosine oxidation in the transition from naive to primed pluripotency. Scientific reports, 10(1), 1-12.
https://www.nature.com/articles/s41598-020-68600-3?elqTrackId=f22b504ca3bf400ca13ed38bda449fd7
* 2i from Axon Medchem

Liu, Y., Bai, H., Guo, F., Thai, P. N., Luo, X., Zhang, P., ... & Lu, X. (2020). PGC-1α activator ZLN005 promotes maturation of cardiomyocytes derived from human embryonic stem cells. Aging (Albany NY), 12(8), 7411.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202542/

Fischer, V., Plassard, D., Ye, T., San Martin, B. R., Stierle, M., Tora, L., & Devys, D. Two Related Coactivator Complexes SAGA and ATAC Control Embryonic Stem Cell Self-Renewal Through Two Different Acetyltransferase-Independent Mechanisms. Available at SSRN 3782006.
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3782006
* 2i from Axon Medchem

Geula, S. (2020). Deciphering the molecular role of N6-Methyladenosine mRNA modification in development of mammalian stem cells (Doctoral dissertation, The Weizmann Institute of Science).
https://weizmann.esploro.exlibrisgroup.com/view/delivery/972WIS_INST/1274920170003596/1374919530003596

Nickels, S. L., Modamio, J., Mendes-Pinheiro, B., Monzel, A. S., Betsou, F., & Schwamborn, J. C. (2020). Reproducible generation of human midbrain organoids for in vitro modeling of Parkinson’s disease. Stem Cell Research, 46, 101870.
https://www.sciencedirect.com/science/article/pii/S1873506120301719

Allijn, I., Ribeiro, M., Poot, A., Passier, R., & Stamatialis, D. (2020). Membranes for modelling cardiac tissue stiffness in vitro based on poly (Trimethylene carbonate) and poly (ethylene glycol) polymers. Membranes, 10(10), 274.
https://www.mdpi.com/2077-0375/10/10/274

Ignatova, V. V., Stolz, P., Kaiser, S., Gustafsson, T. H., Lastres, P. R., Sanz-Moreno, A., ... & Schneider, R. (2020). The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs. Genes & development, 34(9-10), 715-729.
http://genesdev.cshlp.org/content/34/9-10/715.full
* 2i from Axon Medchem

Breuls, N., Giarratana, N., Yedigaryan, L., Carai, P., Heymans, S., Ranga, A., ... & Sampaolesi, M. (2020). Valproic acid stimulates myogenesis in pluripotent stem cell–derived mesodermal progenitors in a Notch-dependent manner. bioRxiv.
https://www.biorxiv.org/content/10.1101/2020.12.16.423053v1.full

Schruf, E. (2020). Recapitulating aspects of alveolar epithelial dysfunction related to idiopathic pulmonary fibrosis utilizing an iPSC-derived air-liquid interface model system (Doctoral dissertation, Universität Ulm).
https://oparu.uni-ulm.de/xmlui/handle/123456789/33478

Shetzer, Y. (2020). Losing the brakes: p53 loss of heterozygosity in malignant transformation of differentiated cells and stem cells (Doctoral dissertation, The Weizmann Institute of Science).
https://weizmann.esploro.exlibrisgroup.com/view/delivery/972WIS_INST/1275000770003596/1375014450003596

Panagiotakopoulou, V., Ivanyuk, D., De Cicco, S., Haq, W., Arsić, A., Yu, C., ... & Deleidi, M. (2020). Interferon-γ signaling synergizes with LRRK2 in neurons and microglia derived from human induced pluripotent stem cells. Nature communications, 11(1), 1-17.
https://www.nature.com/articles/s41467-020-18755-4

van IJzendoorn, D. G., Salvatori, D. C., Cao, X., van den Hil, F., Briaire-de Bruijn, I. H., de Jong, D., ... & Orlova, V. V. (2020). Vascular Tumor Recapitulated in Endothelial Cells from hiPSCs Engineered to Express the SERPINE1-FOSB Translocation. Cell Reports Medicine, 1(9), 100153.
https://www.sciencedirect.com/science/article/pii/S2666379120302007

Spada, F., Schiffers, S., Kirchner, A., Zhang, Y., Arista, G., Kosmatchev, O., ... & Carell, T. (2020). Active turnover of genomic methylcytosine in pluripotent cells. Nature Chemical Biology, 16(12), 1411-1419.
https://www.nature.com/articles/s41589-020-0621-y
* from Axon Medchem (CHIR, CGP, PD, IWR1)
Krupalnik, V. (2020). Aire as a novel factor promoting induction of pluripotency (Doctoral dissertation, The Weizmann Institute of Science).
https://weizmann.esploro.exlibrisgroup.com/view/delivery/972WIS_INST/1275016260003596/1375015250003596
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Sato, T., Sase, M., Ishikawa, S., Kajita, M., Asano, J., Sato, T., ... & Ohteki, T. (2020). Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestine. Scientific reports, 10(1), 1-15.
https://www.nature.com/articles/s41598-020-64987-1

Lange, L., Hoffmann, D., Schwarzer, A., Ha, T. C., Philipp, F., Lenz, D., ... & Schambach, A. (2020). Inducible forward programming of human pluripotent stem cells to hemato-endothelial progenitor cells with hematopoietic progenitor potential. Stem cell reports, 14(1), 122-137.
https://www.sciencedirect.com/science/article/pii/S2213671119304084

Ignatova, V. V., Kaiser, S., Ho, J. S. Y., Bing, X., Stolz, P., Tan, Y. X., ... & Schneider, R. (2020). METTL6 is a tRNA m3C methyltransferase that regulates pluripotency and tumor cell growth. Science advances, 6(35), eaaz4551.
https://advances.sciencemag.org/content/6/35/eaaz4551.abstract

Ohishi, H., Au Yeung, W. K., Unoki, M., Ichiyanagi, K., Fukuda, K., Maenohara, S., ... & Sasaki, H. (2020). Characterization of genetic‐origin‐dependent monoallelic expression in mouse embryonic stem cells. Genes to Cells, 25(1), 54-64.
https://onlinelibrary.wiley.com/doi/abs/10.1111/gtc.12736

Rausch, C., Weber, P., Prorok, P., Hörl, D., Maiser, A., Lehmkuhl, A., ... & Cardoso, M. C. (2020). Developmental differences in genome replication program and origin activation. Nucleic acids research, 48(22), 12751-12777.
https://academic.oup.com/nar/article/48/22/12751/6017362?login=true
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Smits, L. M., Magni, S., Kinugawa, K., Grzyb, K., Luginbühl, J., Sabate-Soler, S., ... & Schwamborn, J. C. (2020). Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids. Cell and tissue research, 382(3), 463-476.
https://link.springer.com/article/10.1007/s00441-020-03249-y

Varga, J., Nicolas, A., Petrocelli, V., Pesic, M., Mahmoud, A., Michels, B. E., ... & Greten, F. R. (2020). AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer. Journal of Experimental Medicine, 217(10).
https://rupress.org/jem/article-abstract/217/10/e20191515/151998

Di Minin, G., Dumeau, C. E., Grison, A., Chan, W., Monfort, A., Jerome-Majewska, L. A., & Wutz, A. (2020). Tmed2 regulates Smoothened trafficking and Hedgehog signalling. bioRxiv.
https://www.biorxiv.org/content/10.1101/2020.04.20.049957v1.full
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Mulholland, C. B., Nishiyama, A., Ryan, J., Nakamura, R., Yiğit, M., Glück, I. M., ... & Leonhardt, H. (2020). Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals. Nature communications, 11(1), 1-24.
https://www.nature.com/articles/s41467-020-19603-1
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Schenke, M. (2020). DOCTOR OF PHILOSOPHY (PhD) (Doctoral dissertation, University of Veterinary Medicine Hannover).
https://elib.tiho-hannover.de/servlets/MCRFileNodeServlet/tiho_derivate_00000305/SchenkeM-ss20%20.pdf

Renner, H., Grabos, M., Becker, K. J., Kagermeier, T. E., Wu, J., Otto, M., ... & Bruder, J. M. (2020). A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids. Elife, 9, e52904.
https://elifesciences.org/articles/52904

Butti, E., Cattaneo, S., Bacigaluppi, M., Cambiaghi, M., Scotti, G., Brambilla, E., ... & Martino, G. (2020). Neural precursor cells contribute to decision-making by tuning striatal connectivity via secretion of IGFBPL-1. bioRxiv.
https://www.biorxiv.org/content/10.1101/2020.12.29.424678v1.full

Rais, Y. (2020). Deterministic reprogramming of somatic cells to pluripotency via regulation of Mbd3/NuRD activity (Doctoral dissertation, The Weizmann Institute of Science).
https://weizmann.esploro.exlibrisgroup.com/view/delivery/972WIS_INST/1275015690003596/1375014170003596

Pieters, T., Sanders, E., Tian, H., van Hengel, J., & Van Roy, F. (2020). Neural defects caused by total and Wnt1-Cre mediated ablation of p120ctn in mice. BMC developmental biology, 20(1), 1-18.
https://link.springer.com/article/10.1186/s12861-020-00222-4
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Rao, V. K., Swarnaseetha, A., Tham, G. H., Lin, W. Q., Han, B. B., Benoukraf, T., ... & Ong, C. T. (2020). Phosphorylation of Tet3 by cdk5 is critical for robust activation of BRN2 during neuronal differentiation. Nucleic acids research, 48(3), 1225-1238.
https://academic.oup.com/nar/article/48/3/1225/5661090?login=true

Warzych, E., Pawlak, P., Lechniak, D., & Madeja, Z. E. (2020). WNT signalling supported by MEK/ERK inhibition is essential to maintain pluripotency in bovine preimplantation embryo. Developmental biology, 463(1), 63-76.
https://www.sciencedirect.com/science/article/pii/S001216062030124X
* many inhibitors used were from Axon Medchem

Moretti, A., Fonteyne, L., Giesert, F., Hoppmann, P., Meier, A. B., Bozoglu, T., ... & Kupatt, C. (2020). Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy. Nature medicine, 26(2), 207-214.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212064/

Liu, Z., Tardat, M., Gill, M. E., Royo, H., Thierry, R., Ozonov, E. A., & Peters, A. H. (2020). SUMO ylated PRC 1 controls histone H3. 3 deposition and genome integrity of embryonic heterochromatin. The EMBO journal, 39(13), e103697.
https://www.embopress.org/doi/full/10.15252/embj.2019103697
(3 μM CHIR99021 and 0.8 μM PD184352, Axon Medchem).

Fischer, B. (2020). Comparative analysis of biopolymer-based scaffolds for therapeutically relevant cells.
https://scidok.sulb.uni-saarland.de/handle/20.500.11880/30668
https://scidok.sulb.uni-saarland.de/bitstream/20.500.11880/30668/1/Dissertation_Benjamin_Fischer.pdf

Evans, R. E. (2020). Biomaterial encapsulation to improve cell therapy for Parkinson's disease (Doctoral dissertation, UCL (University College London)).

Kane, K. I., Jarazo, J., Moreno, E. L., Fleming, R. M., & Schwamborn, J. C. (2020). Passive controlled flow for Parkinson's disease neuronal cell culture in 3D microfluidic devices. Organs-on-a-Chip, 2, 100005.

Ito, H., Watari, K., Shibata, T., Miyamoto, T., Murakami, Y., Nakahara, Y., ... & Ono, M. (2020). Bidirectional regulation between NDRG1 and GSK3β controls tumor growth and is targeted by differentiation inducing factor-1 in glioblastoma. Cancer research, 80(2), 234-248.
https://cancerres.aacrjournals.org/content/80/2/234.full
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Genolet, O., Monaco, A. A., Dunkel, I., Boettcher, M., & Schulz, E. G. (2020). Identification of X-chromosomal genes that drive global X-dosage effects in mammals. bioRxiv.
https://www.biorxiv.org/content/10.1101/2020.03.09.983544v1.full
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Cuartas-López, A. M., & Gallego-Gómez, J. C. (2020). Glycogen synthase kinase 3ß participates in late stages of Dengue virus-2 infection. Memórias do Instituto Oswaldo Cruz, 115.

Nishiyama, A., Mulholland, C. B., Bultmann, S., Kori, S., Endo, A., Saeki, Y., ... & Kumamoto, S. (2020). Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation. Nature Communications, 11(1), 1-17.
https://www.nature.com/articles/s41467-020-15006-4
2i: PD0325901 and CHIR99021 from Axon Medchem

Katsuda, T., Kawamata, M., Inoue, A., Yamaguchi, T., Abe, M., & Ochiya, T. (2020). Long‐term maintenance of functional primary human hepatocytes using small molecules. FEBS letters, 594(1), 114-125.
https://febs.onlinelibrary.wiley.com/doi/abs/10.1002/1873-3468.13582
2i: CHIR99021 and PD0325901 from Axon Medchem

Rao, V. K., Swarnaseetha, A., Tham, G. H., Lin, W. Q., Han, B. B., Benoukraf, T., ... & Ong, C. T. (2020). Phosphorylation of Tet3 by cdk5 is critical for robust activation of BRN2 during neuronal differentiation. Nucleic Acids Research, 48(3), 1225-1238.
https://academic.oup.com/nar/article/48/3/1225/5661090

Mochida, T., Ueno, H., Tsubooka-Yamazoe, N., Hiyoshi, H., Ito, R., Matsumoto, H., & Toyoda, T. (2020). Insulin-Deficient Diabetic Condition Upregulates the Insulin-Secreting Capacity of Human Induced Pluripotent Stem Cell–Derived Pancreatic Endocrine Progenitor Cells After Implantation in Mice. Diabetes, 69(4), 634-646.
https://diabetes.diabetesjournals.org/content/69/4/634.abstract

Bérenger-Currias, N. M., Mircea, M., Adegeest, E., van den Berg, P. R., Feliksik, M., Hochane, M., ... & Semrau, S. (2020). Early neurulation recapitulated in assemblies of embryonic and extraembryonic cells. bioRxiv.
https://www.biorxiv.org/content/10.1101/2020.02.13.947655v1.abstract

Rahimoff, R., & KSR, K. S. R. (2020). 4 Material und Methoden der unveröffentlichten Arbeiten. Untersuchung des Metabolismus nicht-kanonischer DNA-Basen in embryonalen Stammzellen, 121.
https://edoc.ub.uni-muenchen.de/25568/1/Kirchner_Angie_G.pdf#page=137
*3i: PD0325901, CHIR99021, and CGP77675 from Axon Medchem

El-Sehemy, A., Selvadurai, H. J., Ortin-Martinez, A., Pokrajac, N. T., Mamatjan, Y., Tachibana, N., ... & Dirks, P. (2020). Norrin mediates tumor-promoting and-suppressive effects in glioblastoma via Notch and WNT. The Journal of Clinical Investigation. 130(6):3069-3086.
https://www.jci.org/articles/view/128994/pdf

Meek, S., Wei, J., Oh, T., Watson, T., Olavarrieta, J., Sutherland, L., ... & Burdon, T. (2020). A Stem Cell Reporter for Investigating Pluripotency and Self-Renewal in the Rat. Stem Cell Reports. 14 (1), 154-166.
https://www.sciencedirect.com/science/article/pii/S2213671119304151

Tang, L., Wang, H., Dai, B., Wang, X., Zhou, D., Shen, J., ... & Wu, Q. (2020). Human induced pluripotent stem cell-derived cardiomyocytes reveal abnormal TGFβ signaling in type 2 diabetes mellitus. Journal of Molecular and Cellular Cardiology. 142, 53-64.
https://www.sciencedirect.com/science/article/pii/S002228282030081X

Shiozawa, S., Nakajima, M., Okahara, J., Kuortaki, Y., Kisa, F., Yoshimatsu, S., ... & Nikaido, I. (2020). Primed to naïve-like conversion of the common marmoset embryonic stem cells. Stem Cells and Development, 29, 12, https://doi.org/10.1089/scd.2019.0259
https://www.liebertpub.com/doi/abs/10.1089/scd.2019.0259

Haraguchi, S., Dang-Nguyen, T. Q., Wells, D., Fuchimoto, D., Fukuda, T., & Tokunaga, T. (2020). Establishment of porcine nuclear transfer-derived embryonic stem cells using induced pluripotent stem cells as donor nuclei. Journal of Reproduction and Development, 2019-137.
https://www.jstage.jst.go.jp/article/jrd/advpub/0/advpub_2019-137/_article/-char/ja/

Bartoccetti, M., van der Veer, B. K., Luo, X., Khoueiry, R., She, P., Bajaj, M., ... & Koh, K. P. (2020). Regulatory dynamics of Tet1 and Oct4 resolve stages of global DNA demethylation and transcriptomic changes in reprogramming. Cell reports, 30(7), 2150-2169.
https://www.sciencedirect.com/science/article/pii/S2211124720300905
*2i: CHIR99021 and PD0325901 from Axon Medchem

Saraswat, D., Polanco, J. J., Shayya, H. J., Tripathi, A., Welliver, R., Pol, S. U., ... & Dutta, R. (2020). Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following demyelination. bioRxiv.
https://www.biorxiv.org/content/10.1101/2020.01.21.906073v2.abstract

Van Den Brink, L., Brandão, K. O., Yiangou, L., Mol, M. P., Grandela, C., Mummery, C. L., ... & Davis, R. P. (2020). Cryopreservation of human pluripotent stem cell-derived cardiomyocytes is not detrimental to their molecular and functional properties. Stem Cell Research, 43, 101698.
https://www.sciencedirect.com/science/article/pii/S1873506119303289

De Cicco, S., Ivanyuk, D., Haq, W., Panagiotakopoulou, V., Arsic, A., Schoendorf, D., ... & Schneiderhan-Marra, N. (2020). Interferon-γ signaling synergizes with LRRK2 in human neurons and microglia. bioRxiv.
https://www.biorxiv.org/content/10.1101/2020.01.30.925222v1.abstract

Le Harzic, R., Meiser, I., Neubauer, J. C., Riemann, I., Schiffer, M., Stracke, F., & Zimmermann, H. (2020). Diffraction-based technology for the monitoring of contraction dynamics in 3D and 2D tissue models. Biomedical Optics Express, 11(2), 517-532.
https://www.osapublishing.org/abstract.cfm?uri=boe-11-2-517

Marques, L. B., Ottoni, F. M., Pinto, M. C. X., Ribeiro, J. M., de Sousa, F. S., Weinlich, R., ... & Alves, R. J. (2020). Lapachol acetylglycosylation enhances its cytotoxic and pro-apoptotic activities in HL60 cells. Toxicology in Vitro, 65, 104772.
https://www.sciencedirect.com/science/article/pii/S0887233319307131

Katsuda, T., Hosaka, K., Matsuzaki, J., Usuba, W., Prieto-Vila, M., Yamaguchi, T., ... & Ochiya, T. (2020). Transcriptomic dissection of hepatocyte heterogeneity: linking ploidy, zonation, and stem/progenitor cell characteristics. Cellular and molecular gastroenterology and hepatology, 9(1), 161-183.
https://www.sciencedirect.com/science/article/pii/S2352345X19301171

2019 (74 citations)
Karoutas, A., Szymanski, W., Rausch, T., Guhathakurta, S., Rog-Zielinska, E. A., Peyronnet, R., ... & Kimura, H. (2019). The NSL complex maintains nuclear architecture stability via lamin A/C acetylation. Nature Cell Biology, 21(10), 1248-1260.  
https://www.nature.com/articles/s41556-019-0397-z
*2i: CHIR99021 + PD0325901 from Axon Medchem

Hamilton, W. B., Mosesson, Y., Monteiro, R. S., Emdal, K. B., Knudsen, T. E., Francavilla, C., ... & Brickman, J. M. (2019). Dynamic lineage priming is driven via direct enhancer regulation by ERK. Nature, 575(7782), 355-360.
https://www.nature.com/articles/s41586-019-1732-z

Madeja, Z. E., Warzych, E., Pawlak, P., & Lechniak, D. (2019). Inhibitor mediated WNT and MEK/ERK signalling affects apoptosis and the expression of quality related genes in bovine in vitro obtained blastocysts. Biochemical and biophysical research communications, 510(3), 403-408.
https://www.sciencedirect.com/science/article/abs/pii/S0006291X19301421
*CHIR99021, PD0325901, PD184352 and SU5402 from Axon Medchem

M A Garcia-Campos, S Edelheit, U Toth, M Safra, R Shachar, S Viukov, R Winkler, R tNir, L Lasman, A Brandis, J H.Hanna, W Rossmanith, S Schwartz. Deciphering the “m6A Code” via Antibody-Independent Quantitative Profiling. Cell, 2019, 178 (3), 731-747.
https://www.sciencedirect.com/science/article/pii/S0092867419306762
*2i: CHIR99021 and PD0325901 from Axon medchem.

Giulitti, S., Pellegrini, M., Zorzan, I., Martini, P., Gagliano, O., Mutarelli, M., ... & Martello, G. (2019). Direct generation of human naive induced pluripotent stem cells from somatic cells in microfluidics. Nat. Cell Biol, 21, 1-19.
https://www.nature.com/articles/s41556-018-0254-5.pdf?origin=ppub
*6i: CHIR99021, PD0325901, GO6983, WH-4-023, SB590885, and Y27632 from Axon Medchem

Heurtier, V., Owens, N., Gonzalez, I., Mueller, F., Proux, C., Mornico, D., ... & Navarro, P. (2019). The molecular logic of Nanog-induced self-renewal in mouse embryonic stem cells. Nature communications, 10(1), 1109.
https://www.nature.com/articles/s41467-019-09041-z
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Kamenova, I., Mukherjee, P., Conic, S., Mueller, F., El-Saafin, F., Bardot, P., ... & Vincent, S. D. (2019). Co-translational assembly of mammalian nuclear multisubunit complexes. Nature communications, 10(1), 1-15.
https://www.nature.com/articles/s41467-019-09749-y
* 2i: PD0325901 and CHIR99021 from Axon Medchem

Rooijers, K., Markodimitraki, C. M., Rang, F. J., de Vries, S. S., Chialastri, A., de Luca, K. L., ...  Dey, S. & Kind, J. (2019). Simultaneous quantification of protein–DNA contacts and transcriptomes in single cells. Nature biotechnology, 37(7), 766-772.
https://www.nature.com/articles/s41587-019-0150-y
*2i: CHIR99021 and PD0325901 from Axon Medchem

Rooijers, K., Markodimitraki, C. M., Rang, F. J., de Vries, S. S., Chialastri, A., de Luca, K. L., ... & Kind, J. (2019). scDam&T‐seq combines DNA adenine methyltransferase-based labeling of protein-DNA contact sites with transcriptome sequencing to analyze regulatory programs in single cells. Nature biotechnology, 37(7), 766.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609448/
*2i: CHIR99021 and PD0325901 from Axon Medchem

Li, J., Rozwadowska, N., Clark, A., Fil, D., Napierala, J. S., & Napierala, M. (2019). Excision of the expanded GAA repeats corrects cardiomyopathy phenotypes of iPSC-derived Friedreich's ataxia cardiomyocytes. Stem cell research, 40, 101529.
https://www.sciencedirect.com/science/article/pii/S187350611930159X

B. Di Stefano, E.C. Luo, C. Haggerty, ..., A. Meissner, Gene W. Yeo, K. Hochedlinger (2019) The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis. Cell Stem Cell, 25, 1-17.
http://yeolab.github.io/papers/2019/Stefano_Enching_cellstemmcell_2019.pdf
* IM-12, SB590885, WH-4-23, PD0325901, CHIR99021, Y-27632 from Axon Medchem

Toyoda, T., Kimura, A., Tanaka, H., & Osafune, K. (2019). Efficient Generation of Pancreas/Duodenum Homeobox Protein 1+ Posterior Foregut/Pancreatic Progenitors from hPSCs in Adhesion Cultures. JoVE (Journal of Visualized Experiments), (145), e57641.
https://www.jove.com/video/57641/efficient-generation-pancreasduodenum-homeobox-protein-1-posterior

Goodrich, L. (2019). Mutational Analysis of Xist and the X-inactivation Center (Doctoral dissertation, UCSF).
https://escholarship.org/content/qt94k5n9jh/qt94k5n9jh.pdf

Heap, R. E., Segarra-Fas, A., Blain, A. P., Findlay, G. M., & Trost, M. (2019). Profiling embryonic stem cell differentiation by MALDI TOF mass spectrometry: development of a reproducible and robust sample preparation workflow. Analyst, 144(21), 6371-6381.
https://pubs.rsc.org/en/content/articlehtml/2019/an/c9an00771g
2i: from Axon Medchem

De Clerck, L., Taelman, J., Popovic, M., Willems, S., Van der Jeught, M., Heindryckx, B., ... & Dhaenens, M. (2019). Untargeted histone profiling during naive conversion uncovers conserved modification markers between mouse and human. Scientific reports, 9(1), 1-11.
https://www.nature.com/articles/s41598-019-53681-6
* CHIR99021 and BIRB796 from Axon Medchem

Monzel, A. S., Hemmer, K., Mukendi, T. K., Lucarelli, P., Rosety, I., Zagare, A., ... & Azuaje, F. (2019). Machine learning-assisted neurotoxicity prediction in human midbrain organoids. bioRxiv, 774240.
https://www.biorxiv.org/content/10.1101/774240v1.abstract

Drowley, L., McPheat, J., Nordqvist, A., Peel, S., Karlsson, U., Martinsson, S., ... & Sánchez, J. (2019). Discovery of retinoic acid receptor agonists as proliferators of cardiac progenitor cells through a phenotypic screening approach. Stem cells translational medicine.
https://stemcellsjournals.onlinelibrary.wiley.com/doi/abs/10.1002/sctm.19-0069

Qiu, Q., Hu, P., Govek, K. W., Camara, P. G., & Wu, H. (2019). Massively parallel, time-resolved single-cell RNA sequencing with scNT-Seq. bioRxiv.
https://www.biorxiv.org/content/10.1101/2019.12.19.882050v1.full
2i: CHIR99021 and PD0325901 from Axon Medchem

Vanheer, L., Song, J., De Geest, N., Janiszewski, A., Talon, I., Provenzano, C., ... & Pasque, V. (2019). Tox4 modulates cell fate reprogramming. Journal of cell science, 132(20), jcs232223.
https://jcs.biologists.org/content/joces/132/20/jcs232223.full.pdf

S Tanigawa, H Naganuma, Y Kaku, T Era, T Sakuma, T Yamamoto, A Taguchi, R Nishinakamura. Activin Is Superior to BMP7 for Efficient Maintenance of Human iPSC-Derived Nephron Progenitors. Stem Cell Reports. 2019, 13 (2), 322-337.
https://www.sciencedirect.com/science/article/pii/S2213671119302553

Otomo, N., Takeda, K., Kawai, S., Kou, I., Guo, L., Osawa, M., ... & Yasuhiko, Y. (2019). Bi-allelic loss of function variants of TBX6 causes a spectrum of malformation of spine and rib including congenital scoliosis and spondylocostal dysostosis. Journal of medical genetics, jmedgenet-2018.
https://www.ncbi.nlm.nih.gov/pubmed/31015262  

Yoshida, Y., Soma, T., Matsuzaki, T., & Kishimoto, J. (2019). Wnt activator CHIR99021-stimulated human dermal papilla spheroids contribute to hair follicle formation and production of reconstituted follicle-enriched human skin. Biochemical and biophysical research communications, 516(3), 599-605.
https://www.sciencedirect.com/science/article/pii/S0006291X19311611

Okuyama, H., Ohnishi, H., Nakamura, R., Yamashita, M., Kishimoto, Y., Tateya, I., ... & Omori, K. (2019). Transplantation of multiciliated airway cells derived from human iPS cells using an artificial tracheal patch into rat trachea. Journal of tissue engineering and regenerative medicine, 13(6), 1019-1030.
https://onlinelibrary.wiley.com/doi/abs/10.1002/term.2849

Dierickx, P., Emmett, M. J., Jiang, C., Uehara, K., Liu, M., Adlanmerini, M., & Lazar, M. A. (2019). SR9009 has REV-ERB–independent effects on cell proliferation and metabolism. Proceedings of the National Academy of Sciences, 116(25), 12147-12152.
https://www.pnas.org/content/116/25/12147
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Bluhmki, T., Traub, S., Schruf, E., Garnett, J., Gantner, F., Bischoff, D., & Heilker, R. (2019). Differentiation of hiPS Cells into Definitive Endoderm for High-Throughput Screening. In Cell-Based Assays Using iPSCs for Drug Development and Testing (pp. 101-115). Humana, New York, NY.
https://link.springer.com/protocol/10.1007/978-1-4939-9477-9_9

Minami, T., Ishii, T., Yasuchika, K., Fukumitsu, K., Ogiso, S., Miyauchi, Y., ... & Kawamoto, H. (2019). Novel hybrid three-dimensional artificial liver using human induced pluripotent stem cells and a rat decellularized liver scaffold. Regenerative therapy, 10, 127-133.
https://www.sciencedirect.com/science/article/pii/S235232041830107X

Malaguti, M., Migueles, R. P., Blin, G., Lin, C. Y., & Lowell, S. (2019). Id1 Stabilizes Epiblast Identity by Sensing Delays in Nodal Activation and Adjusting the Timing of Differentiation. Developmental cell. 50(4), 462-477.
https://www.sciencedirect.com/science/article/pii/S1534580719304459
* CHIR99021, LDN193189 and PD0325901 from Axon Medchem

Yang, S., Ding, S., He, S., He, L., Gao, K., Peng, S., & Shuai, C. (2019). Differentiation of primordial germ cells from premature ovarian insufficiency-derived induced pluripotent stem cells. Stem cell research & therapy, 10(1), 156.
https://stemcellres.biomedcentral.com/articles/10.1186/s13287-019-1261-6

Weber, P., Rausch, C., Scholl, A., & Cardoso, M. C. (2019). Repli-FISH (Fluorescence in Situ Hybridization): Application of 3D-(Immuno)-FISH for the Study of DNA Replication Timing of Genetic Repeat Elements.
http://www.cardoso-lab.org/publications/Weber,%20Rausch%202019.pdf
*2i: CHIR99021 and PD0325901 from Axon Medchem

Hirabayashi, M., Takizawa, A., & Hochi, S. (2019). Embryonic Stem Cells and Gene Manipulation in Rat. In Rat Genomics (pp. 115-130). Humana, New York, NY.
https://link.springer.com/protocol/10.1007/978-1-4939-9581-3_5

Nakajima, M., Yoshimatsu, S., Sato, T., Nakamura, M., Okahara, J., Sasaki, E., ... & Okano, H. (2019). Establishment of induced pluripotent stem cells from common marmoset fibroblasts by RNA-based reprogramming. Biochemical and biophysical research communications.
https://www.sciencedirect.com/science/article/pii/S0006291X19310939

Saludas, L., Garbayo, E., Mazo, M., Abizanda, G., Garcia, O. I., Raya, A., ... & Blanco-prieto, M. J. (2019). Long-term engraftment of human cardiomyocytes combined with biodegradable microparticles induces heart repair. Journal of Pharmacology and Experimental Therapeutics, jpet-118.
http://jpet.aspetjournals.org/content/jpet/early/2019/02/06/jpet.118.256065.full.pdf
*CHIR99021 and C-59 from Axon Medchem

Wu, H., Vonk, K. K., van der Maarel, S. M., Santen, G. W., & Daxinger, L. (2019). A functional assay to classify ZBTB24 missense variants of unknown significance. Human mutation.
https://onlinelibrary.wiley.com/doi/abs/10.1002/humu.23786
2i: CHIR99021 and PD0325901 from Axon Medchem

Smits, L. M., Reinhardt, L., Reinhardt, P., Glatza, M., Monzel, A. S., Stanslowsky, N., ... & Nicklas, S. M. (2019). Modeling Parkinson’s disease in midbrain-like organoids. NPJ Parkinson's disease, 5(1), 5.
https://www.nature.com/articles/s41531-019-0078-4

Cosset, E., Locatelli, M., Marteyn, A., Lescuyer, P., Antonia, F. D., Mor, F. M., ... & Tieng, V. (2019). Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases. JoVE (Journal of Visualized Experiments), (148), e59682.
https://www.jove.com/video/59682/human-neural-organoids-for-studying-brain-cancer-neurodegenerative
* CHIR99021 and LDN193189 from Axon Medchem

An, S., Park, U. H., Moon, S., Kang, M., Youn, H., Hwang, J. T., ... & Um, S. J. (2019). Asxl1 ablation in mouse embryonic stem cells impairs neural differentiation without affecting self-renewal. Biochemical and biophysical research communications, 508(3), 907-913.
https://www.sciencedirect.com/science/article/pii/S0006291X18326901
* 3i: SU5402, PD184352 and CHIR99021 from Axon Medchem

Katsuda, T., Matsuzaki, J., Yamaguchi, T., Yamada, Y., Hosaka, K., Takeuchi, A., ... & Ochiya, T. (2019). Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes. BioRxiv, 601922.
https://www.biorxiv.org/content/10.1101/601922v1.abstract

Cao, X., Yakala, G. K., van den Hil, F. E., Cochrane, A., Mummery, C. L., & Orlova, V. V. (2019). Differentiation and Functional Comparison of Monocytes and Macrophages from hiPSCs with Peripheral Blood Derivatives. Stem cell reports, 12(6), 1282-1297.
https://www.sciencedirect.com/science/article/pii/S2213671119301705

Bursch, F., Kalmbach, N., Naujock, M., Staege, S., Eggenschwiler, R., Abo-Rady, M., ... & Boeckers, T. M. (2019). Altered calcium dynamics and glutamate receptor properties in iPSC derived motor neurons from ALS patients with C9orf72, FUS, SOD1 or TDP43 mutations. Human molecular genetics.
https://academic.oup.com/hmg/advance-article-abstract/doi/10.1093/hmg/ddz107/5492438

Schöneborn, H., Raudzus, F., Secret, E., Otten, N., Michel, A., Fresnais, J., ... & Heumann, R. (2019). Novel Tools towards Magnetic Guidance of Neurite Growth:(I) Guidance of Magnetic Nanoparticles into Neurite Extensions of Induced Human Neurons and In Vitro Functionalization with RAS Regulating Proteins. Journal of functional biomaterials, 10(3), 32.
https://www.mdpi.com/2079-4983/10/3/32

Duval, N., Vaslin, C., Barata, T. C., Frarma, Y., Contremoulins, V., Baudin, X., ... & Ribes, V. C. (2019). BMP4 patterns Smad activity and generates stereotyped cell fate organization in spinal organoids. Development, 146(14), dev175430.
https://dev.biologists.org/content/146/14/dev175430.full

Boonen, T. M. P. M. (2019). Development of a myocardial infarction model by the design of a miniaturized 3D culture platform (Master's thesis, University of Twente).
https://essay.utwente.nl/79975/1/Master%20thesis%20T.M.P.M.%20Boonen.pdf 
Azacytidines Directly in the Genome. Helvetica Chimica Acta, 102(3), e1800229.
https://onlinelibrary.wiley.com/doi/abs/10.1002/hlca.201800229
* 2i from Axon Medchem

Aizawa, E., 2019. Characterization of in vitro systems to generate oocytes and substitutes of sperm from pluripotent stem cells (Doctoral dissertation, ETH Zurich).
https://www.research-collection.ethz.ch/bitstream/handle/20.500.11850/391005/1/Dissertation_EishiAizawa.pdf
* 2i from Axon Medchem

Spada, F., Schiffers, S., Kirchner, A., Zhang, Y., Kosmatchev, O., Korytiakova, E., ... & Carell, T. (2019). Oxidative and non-oxidative active turnover of genomic methylcytosine in distinct pluripotent states. BioRxiv, 846584.
https://www.biorxiv.org/content/10.1101/846584v1.full
* Axon Medchem (CHIR, CGP, PD, IWR1)

Smits, L. M., Magni, S., Grzyb, K., Antony, P. M., Krüger, R., Skupin, A., ... & Schwamborn, J. (2019). Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids. bioRxiv, 589598.
https://www.biorxiv.org/content/10.1101/589598v1.abstract

Amit, I., David, L.A. and Meital, G.U.R.Y., Yeda Research and Development Co Ltd, 2019. Methods and kits for analyzing dna binding moieties attached to dna. U.S. Patent Application 16/319,499.
https://patents.google.com/patent/US20190203270A1/en
* 2i: PD0325901 and CHIR99021 from Axon Medchem

Hill, R. J., & Crossan, G. P. (2019). DNA cross-link repair safeguards genomic stability during premeiotic germ cell development. Nature genetics, 51(8), 1283.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675612/
2i: Pd0325901 and CHIR99021 from Axon

Canizo, J. R., Rivolta, A. E. Y., Echegaray, C. V., Suvá, M., Alberio, V., Aller, J. F., ... & Alberio, R. (2019). A dose-dependent response to MEK inhibition determines hypoblast fate in bovine embryos. BMC developmental biology, 19(1), 13.
https://bmcdevbiol.biomedcentral.com/articles/10.1186/s12861-019-0193-9
* PD0325901, GO6983 from Axon Medchem

Ooi, J., Langley, S. R., Xu, X., Utami, K. H., Sim, B., Huang, Y., ... & Low, D. (2019). Unbiased profiling of isogenic Huntington disease hPSC-derived CNS and peripheral cells reveals strong cell-type specificity of CAG length effects. Cell reports, 26(9), 2494-2508.
https://www.sciencedirect.com/science/article/pii/S2211124719301706

Larsen, S. (2019). PHENOTYPIC CHARACTERIZATION OF CELLULAR MODELS OF VPS35-ASSOCIATED MUTATION IN PARKINSON’S DISEASE (Doctoral dissertation, University of Luxembourg, Belvaux, Luxembourg).
https://orbilu.uni.lu/bitstream/10993/40938/1/Larsen_thesis_FSTC_2019_56.pdf

Postlmayr, A. (2019). DCK8–A New Modulator for X-Chromosome Inactivation (Doctoral dissertation, ETH Zurich).
https://www.research-collection.ethz.ch/bitstream/handle/20.500.11850/341767/1/PhDTHESISPostlmayr.pdf

Ripani, P. (2019). Synergy between thiazolides and glutathione-S-transferases in cell death induction in colorectal tumor cells (Doctoral dissertation).
https://kops.uni-konstanz.de/bitstream/handle/123456789/48634/Ripani_2-132onngy88tg9.pdf?sequence=3

García-Pérez, A. (2019). Generation of pacemaker cardiomyocytes based on hHCN4 overexpression in hiPSCs by the Sleeping Beauty transposon system (Doctoral dissertation).
https://refubium.fu-berlin.de/bitstream/handle/fub188/26224/FINAL_Thesis.pdf?sequence=1&isAllowed=y&save=y

Halsberghe, E. (2019). The Use of CRISPR/Cas9 to Study the Function of Pluripotency-Associated Genes in Human Embryonic Stem Cells (Doctoral dissertation, Ghent University).
https://lib.ugent.be/fulltxt/RUG01/002/782/982/RUG01-002782982_2019_0001_AC.pdf

Pegg, A. K. (2019). BMP signalling via Id proteins in mesoderm progenitor cell differentiation.
https://era.ed.ac.uk/bitstream/handle/1842/36159/Pegg2019.pdf?sequence=1&isAllowed=y

Ekberg, J., Hansson, M., Doehn, U., Hess, K. and Funa, N., Novo Nordisk AS and Takara Bio Europe AB, 2019. Generation of pancreatic endoderm from pluripotent stem cells using small molecules. U.S. Patent 10,221,392.
https://patents.google.com/patent/US10221392B2/en

Goto, T., Hara, H., Sanbo, M., Masaki, H., Sato, H., Yamaguchi, T., ... & Hirabayashi, M. (2019). Generation of pluripotent stem cell-derived mouse kidneys in Sall1-targeted anephric rats. Nature communications, 10(1), 451.
 
Tang, L., Yao, F., Wang, H., Wang, X., Shen, J., Dai, B., ... & Li, T. (2019). Inhibition of TRPC1 prevents cardiac hypertrophy via NF-κB signaling pathway in human pluripotent stem cell-derived cardiomyocytes. Journal of molecular and cellular cardiology, 126, 143-154.
*CHIR99021 and IWR-1 from Axon Medchem
 
Yoshimura, Y., Taguchi, A., & Nishinakamura, R. (2019). Generation of Three-Dimensional Nephrons from Mouse and Human Pluripotent Stem Cells. In Kidney Organogenesis (pp. 87-102). Humana Press, New York, NY.
 
OCHIYA, T; KATSUDA, T. Method for producing hepatic stem/precursor cells from mature hepatic cells using low-molecular-weight compound. U.S. Patent Application No 16/068,607, 2019.
*CHIR99021, PD0325901 and GSK269962A from Axon Medchem
 
Vila-Cejudo, M., Massafret, O., Santaló, J., & Ibáñez, E. (2019). Single blastomeres as a source of mouse embryonic stem cells: effect of genetic background, medium supplements, and signaling modulators on derivation efficiency. Journal of assisted reproduction and genetics, 36(1), 99-111.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Katsuda, T., & Ochiya, T. (2019). Chemically Induced Liver Progenitors (CLiPs): A Novel Cell Source for Hepatocytes and Biliary Epithelial Cells. In Hepatic Stem Cells (pp. 117-130). Humana Press, New York, NY.
 
Zviran, A., Mor, N., Rais, Y., Gingold, H., Peles, S., Chomsky, E., ... & Manor, Y. S. (2019). Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules. Cell stem cell, 24(2), 328-341.
*2i: CHIR99021 + PD0325901, and 10058-F4 from Axon Medchem
 
Stathakos, P., Jimenez-Moreno, N., Crompton, L., Nistor, P., Caldwell, M. A., & Lane, J. D. (2019). Imaging Autophagy in hiPSC-Derived Midbrain Dopaminergic Neuronal Cultures for Parkinson’s Disease Research. In Autophagy (pp. 257-280). Humana Press, New York, NY.
 
Yoshimura, Y., Taguchi, A., Tanigawa, S., Yatsuda, J., Kamba, T., Takahashi, S., ... & Nishinakamura, R. (2019). Manipulation of Nephron-Patterning Signals Enables Selective Induction of Podocytes from Human Pluripotent Stem Cells. Journal of the American Society of Nephrology, 30(2), 304-321.
 
Frank, S., Ahuja, G., Bartsch, D., Russ, N., Yao, W., Kuo, J. C. C., ... & Messling, J. E. (2019). yylncT Defines a Class of Divergently Transcribed lncRNAs and Safeguards the T-mediated Mesodermal Commitment of Human PSCs. Cell stem cell, 24(2), 318-327.
*CHIR99021 and Y27632 from Axon Medchem
 
An, S., Park, U. H., Moon, S., Kang, M., Youn, H., Hwang, J. T., ... & Um, S. J. (2019). Asxl1 ablation in mouse embryonic stem cells impairs neural differentiation without affecting self-renewal. Biochemical and biophysical research communications, 508(3), 907-913.
*3i: SU5402, PD0325901 and CHIR99021 from Axon Medchem
 
Duval, N., Vaslin, C., Barata, T. C., Nedelec, S., & Ribes, V. C. (2019). BMP4 patterns Smad activity and generates stereotyped cell fate organisation in spinal organoids. bioRxiv, 511899.
 
Kuo, J. C. C., Derks, J. P., Akhade, V. S., Kargapolova, Y., Vargas, N. E., Kuroczik, A., ... & Sachinidis, A. (2019). yylncT Defines a Class of Divergently Transcribed lncRNAs and Safeguards the T-mediated Mesodermal Commitment of Human PSCs. Cell Stem Cell, 24, 1-10.
*CHIR99021 and Y27632 from Axon Medchem
 
Khateb, M., Azriel, A., & Levi, B. Z. (2019). The Third Intron of IRF8 Is a Cell-Type-Specific Chromatin Priming Element during Mouse Embryonal Stem Cell Differentiation. Journal of molecular biology, 431(2), 210-222.
*2i: PD0325910 and CHIR99021 from Axon Medchem
 
Heap, R. E., Fas, A. S., Findlay, G., & Trost, M. (2019). Profiling embryonic stem cell differentiation by MALDI-MS: development of a reproducible and robust sample preparation workflow. bioRxiv, 536664.
*2i: PD0325901 and CHIR99021 from Axon Medchem
 
Madeja, Z. E., Warzych, E., Pawlak, P., & Lechniak, D. (2019). Inhibitor mediated WNT and MEK/ERK signalling affects apoptosis and the expression of quality related genes in bovine in vitro obtained blastocysts. Biochemical and biophysical research communications.
*2i: CHIR99021, PD0325901, PD184352, SU5402 from Axon Medchem
 
Rooijers, K., Markodimitraki, C., Rang, F., de Vries, S., Chialastri, A., de Luca, K., ... & Dey, S. (2019). Simultaneous quantification of protein-DNA contacts and transcriptomes in single cells. bioRxiv, 529388.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
2018 (79 citations; with 15 highlighted publications (#) in prestigious journals)
# Metzis, V., Steinhauser, S., Pakanavicius, E., Gouti, M., Stamataki, D., Ivanovitch, K., ... & Luscombe, N. M. (2018). Nervous system regionalization entails axial allocation before neural differentiation. Cell, 175(4), 1105-1118.
 
# Sonnen, K. F., Lauschke, V. M., Uraji, J., Falk, H. J., Petersen, Y., Funk, M. C., ... & Aulehla, A. (2018). Modulation of phase shift between Wnt and Notch signaling oscillations controls mesoderm segmentation. Cell, 172(5), 1079-1090.
 
# Giulitti, S., Pellegrini, M., Zorzan, I., Martini, P., Gagliano, O., Mutarelli, M., ... & Martello, G. (2018). Direct generation of human naive induced pluripotent stem cells from somatic cells in microfluidics. Nature cell biology.
*6i: CHIR99021, PD0325901, GO6983, WH-4-023, SB590885, and Y27632 from Axon Medchem
 
# Bahat, A., Goldman, A., Zaltsman, Y., Khan, D. H., Halperin, C., Amzallag, E., ... & Schimmer, A. D. (2018). MTCH2-mediated mitochondrial fusion drives exit from naïve pluripotency in embryonic stem cells. Nature communications, 9(1), 5132.
 
# Ito, Y., Nakamura, S., Sugimoto, N., Shigemori, T., Kato, Y., Ohno, M., ... & Eto, K. (2018). Turbulence activates platelet biogenesis to enable clinical scale ex vivo production. Cell, 174(3), 636-648.
*CHIR9901, LY294002, PRT4165, SB431542, IOX2 from Axon Medchem
 
# K.F. Sonnen, V.M. Lauschke, J. Uraji, H.J. Falk, Y. Petersen, M.C.Funk, M. Beaupeux, P. François, C.A. Merten, A. Aulehla. (2018). Modulation of Phase Shift between Wnt and Notch Signaling Oscillations Controls Mesoderm Segmentation.
Cell, 2018, 172(5), 1079-1090.e12
 
# Mor, N., Rais, Y., Sheban, D., Peles, S., Aguilera-Castrejon, A., Zviran, A., ... & Hanna J.H. (2018). Neutralizing Gatad2a-Chd4-Mbd3/NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency. Cell stem cell. 23 (3), 412-425.e10
*CHIR99021, PD0325901, GO6983, CPG77675, Y27632, DBZ from Axon Medchem
 
# Barakat, T. S., Halbritter, F., Zhang, M., Rendeiro, A. F., Perenthaler, E., Bock, C., & Chambers, I. (2018). Functional dissection of the enhancer repertoire in human embryonic stem cells. Cell stem cell, 23(2), 276-288.
*2i: CHIR99021 + PD0325901 from Axon Medchem
 
# Peruzzotti-Jametti, L., Bernstock, J. D., Vicario, N., Costa, A. S., Kwok, C. K., Leonardi, T., ... & Mallucci, G. (2018). Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation. Cell Stem Cell.
 
# Sahakyan, A., Clement, K., Clowers, K. J., Erickson, A. R., Shioda, K., Gygi, S. P., ... & Hochedlinger. K. Reduced MEK inhibition preserves genomic stability in naive human embryonic stem cells. Nature Methods. 15, 732–740.
*CHIR99021, PD0325901, GO6983, Y27632, IM12, SB590885, WH4-023 .. from Axon Medchem
 
# Yasuda, S. Y., Ikeda, T., Shahsavarani, H., Yoshida, N., Nayer, B., Hino, M., ... & Hasegawa, K. (2018). Chemically defined and growth-factor-free culture system for the expansion and derivation of human pluripotent stem cells. Nature Biomedical Engineering, 2(3), 173.
 
# Senís, E., Mosteiro, L., Wilkening, S., Wiedtke, E., Nowrouzi, A., Afzal, S., ... & Grimm, D (2018). AAVvector-mediated in vivo reprogramming into pluripotency. Nature communications, 9(1), 2651.
*2i: CHIR99021 + PD0325901 from Axon Medchem
 
# Kilens, S., Meistermann, D., Moreno, D., Chariau, C., Gaignerie, A., Reignier, A., ... & Flippe, L. (2018). Parallel derivation of isogenic human primed and naive induced pluripotent stem cells. Nature communications, 9(1), 360.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
# Pfeiffer, M. J., Quaranta, R., Piccini, I., Fell, J., Rao, J., Röpke, A., ... & Greber, B. (2018). Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES. Nature communications, 9(1), 440.
 
# de Jesus, B. B., Marinho, S. P., Barros, S., Sousa-Franco, A., Alves-Vale, C., Carvalho, T., & Carmo-Fonseca, M. (2018). Silencing of the lncRNA Zeb2-NAT facilitates reprogramming of aged fibroblasts and safeguards stem cell pluripotency. Nature communications, 9(1), 94.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Todaro, F., Campolo, F., Barrios, F., Pellegrini, M., Di Cesare, S., Tessarollo, L., ... & Dolci, S. (2018). Regulation of Kit expression in early mouse embryos and ES cells. STEM CELLS.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Heo, H. R., Song, H., Kim, H. R., Lee, J. E., Chung, Y. G., Kim, W. J., ... & Hong, S. H. (2018). Reprogramming mechanisms influence the maturation of hematopoietic progenitors from human pluripotent stem cells. Cell death & disease, 9(11), 1090.
 
Skvortsova, E. V., Sinenko, S. A., & Tomilin, A. N. (2018). Immortalized murine fibroblast cell lines are refractory to reprogramming to pluripotent state. Oncotarget, 9(81), 35241.
 
Berger, E., Magliaro, C., Paczia, N., Monzel, A. S., Antony, P., Linster, C. L., ... & Schwamborn, J. C. (2018). Millifluidic culture improves human midbrain organoid vitality and differentiation. Lab on a Chip, 18(20), 3172-3183.
 
YAZAWA, Masayuki; SONG, LouJin. Methods for Cardiac Differentiation of Human Induced Pluripotent Stem Cells. U.S. Patent Application No 15/755,812, 2018.
 
OSAFUNE, Kenji; TOYODA, Taro; KIMURA, Azuma. Method for producing pancreatic bud cells. U.S. Patent Application No 15/760,523, 2018.
*CHIR99021 and LDN193189 from Axon Medchem
 
Mae, S. I., Ryosaka, M., Toyoda, T., Matsuse, K., Oshima, Y., Tsujimoto, H., ... & Osafune, K. (2018). Generation of branching ureteric bud tissues from human pluripotent stem cells. Biochemical and biophysical research communications, 495(1), 954-961.
*CHIR99021 and LDN193189 from Axon Medchem
 
Kamenova, I., Mukherjee, P., Conic, S., Mueller, F., El-Saafin, F., Bardot, P., ... & Vincent, S. D. (2018). Co-translation drives the assembly of mammalian nuclear multisubunit complexes. bioRxiv, 419812.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Yuan, J., Ma, Y., Huang, T., Chen, Y., Peng, Y., Li, B., ... & Ding, Q. (2018). Genetic modulation of RNA splicing with a CRISPR-guided cytidine deaminase. Molecular cell, 72(2), 380-394.
 
Aguilar‐Bravo, B., Rodrigo‐Torres, D., Ariño, S., Coll, M., Pose, E., Blaya, D., ... & Dubuquoy, L. (2018). Ductular reaction cells display an inflammatory profile and recruit neutrophils in alcoholic hepatitis. Hepatology.
* CHIR99021, Y27632 and A83-01 from Axon Medchem
 
Hamanaka, S., Umino, A., Sato, H., Hayama, T., Yanagida, A., Mizuno, N., ... & Masaki, H. (2018). Generation of vascular endothelial cells and hematopoietic cells by blastocyst complementation. Stem cell reports, 11(4), 988-997.
 
BOLOGNIN, Silvia; MONZEL, Anna; SCHWAMBORN, Jens. Means and methods for generating midbrain organoids. U.S. Patent Application No 15/766,779, 2018.
 
Dwivedi, O. P., Lehtovirta, M., Hastoy, B., Chandra, V., Kleiner, S., Jain, D., ... & Hansson, O. (2018). Loss of ZnT8 function protects against diabetes by enhanced insulin secretion. bioRxiv, 436030.
 
Ghimire, S., Van der Jeught, M., Neupane, J., Roost, M. S., Anckaert, J., Popovic, M., ... & Menten, B. (2018). Comparative analysis of naive, primed and ground state pluripotency in mouse embryonic stem cells originating from the same genetic background. Scientific reports, 8(1), 5884.
Strakova, K., Kowalski-Jahn, M., Gybel, T., Valnohova, J., Dhople, V. M., Harnos, J., ... & Lindskog, C. (2018). Dishevelled enables casein kinase 1–mediated phosphorylation of Frizzled 6 required for cell membrane localization. Journal of Biological Chemistry, 293(48), 18477-18493.
 
Rehbach, K. (2018). Rapid semi-automated phenotypic assays for compound testing in patient-derived SPG4 neurons (Doctoral dissertation, Universitäts-und Landesbibliothek Bonn).
 
GÜNTHER, Katharina. Generation of early human neuroepithelial progenitors from primary cells for biomedical applications. 2018.
 
Van Haver, S. (2018). DEVELOPMENT OF A HUMAN EMBRYONIC STEM CELL BASED PLATFORM FOR NEUROBLASTOMA TUMOUR MODELLING (Doctoral dissertation, Ghent University).
*CHIR99021, LDN193189 ans SB431532 from Axon Medchem
 
Zviran, A., Mor, N., Rais, Y., Gingold, H., Peles, S., Chomsky, E., ... & Manor, Y. S. (2018). The Molecular and Functional Foundations of Conducive Somatic Cell Reprogramming to Ground State Pluripotency.
 
NAKATSUJI, Norio; MINAMI, Itsunari. Composition for promoting cardiac differentiation of pluripotent stem cell comprising EGFR inhibitor. U.S. Patent Application No 10/196,609, 2019.
 
GOTOH, Shimpei, et al. Method for inducing differentiation of alveolar epithelial cells. U.S. Patent Application No 15/555,183, 2018.
 
Duthoo, E. (2018). IN VITRO GENERATION OF STEM CELL DERIVED GAMETES (Doctoral dissertation, Ghent University).
*CHIR99021 and BIRB0796 from Axon Medchem
 
Foster, B. M., Stolz, P., Mulholland, C. B., Montoya, A., Kramer, H., Bultmann, S., & Bartke, T. (2018). Critical role of the UBL domain in stimulating the E3 ubiquitin ligase activity of UHRF1 toward chromatin. Molecular cell, 72(4), 739-752.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Bursch, F. (2018). Studies on pathomechanisms and novel therapies in amyotrophic lateral sclerosis (Doctoral dissertation, University of Veterinary Medicine Hannover).
 
TZAHOR, Eldad, et al. Methods, kits and devices for promoting cardiac regeneration. U.S. Patent Application No 15/147,178, 2018.
  
TZAHOR, Eldad, et al. Methods, kits and devices for promoting cardiac regeneration. U.S. Patent Application No 10/017,574, 2018.
 
HUCH ORTEGA, Meritxell; CAROLUS, Johannes. LIVER ORGANOID, USES THEREOF AND CULTURE METHOD FOR OBTAINING THEM. U.S. Patent Application No 15/665,363, 2018.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Cuartas-López, A. M., Hernández-Cuellar, C. E., & Gallego-Gómez, J. C. (2018). Disentangling the Role of PI3K/Akt, Rho GTPase and the Actin Cytoskeleton on Dengue Virus Infection. Virus Research, 256, 153-165
 
Mulholland, C. B., Traube, F. R., Parsa, E., Eckl, E. M., Schoenung, M., Modic, M., ... & Bultmann, S. (2018). Distinct and stage-specific contributions of TET1 and TET2 to stepwise cytosine oxidation in the transition from naive to primed pluripotency. bioRxiv, 281519.
*2i: CHIR99021 + PD0325901 from Axon Medchem
 
Mulholland, C. B., Ryan, J., Qin, W., Bartoschek, M. D., Traube, F. R., Parsa, E., ... & Leonhardt, H. (2018). TET1 drives global DNA demethylation via DPPA3-mediated inhibition of maintenance methylation. bioRxiv, 321604.
*2i: CHIR99021 + PD0325901 from Axon Medchem
 
Dahlmann, J., Awad, G., Dolny, C., Weinert, S., Richter, K., Fischer, K. D., ... & Kensah G. (2018). Generation of functional cardiomyocytes from rat embryonic and induced pluripotent stem cells using feeder-free expansion and differentiation in suspension culture. PloS one, 13(3), e0192652.
 
Nose, N., Werner, R. A., Ueda, Y., Günther, K., Lapa, C., Javadi, M. S., ... & Higuchi T. (2018). Metabolic substrate shift in human induced pluripotent stem cells during cardiac differentiation: Functional assessment using in vitro radionuclide uptake assay. International Journal of Cardiology. in press.
 
SHOJI, Masanobu. Method for producing dopaminergic neurons. U.S. Patent Application No 10/017,734, 2018.
*CHIR99021, LDN193189, SU5402, SB431542, PD184352, PD173074 ... from Axon Medchem
 
OSAFUNE, Kenji; KOTAKA, Maki. Hepatocyte induction method. U.S. Patent Application No 15/539,042, 2018.
 
Shen, J., Wang, X., Zhou, D., Li, T., Tang, L., Gong, T., ... & Liang, P. (2018). Modelling cadmium‐induced cardiotoxicity using human pluripotent stem cell‐derived cardiomyocytes. Journal of cellular and molecular medicine.
*CHIR99021 and IWR-1 from Axon Medchem
 
Hoshina, A., Kawamoto, T., Sueta, S. I., Mae, S. I., Araoka, T., Tanaka, H., ... & Osafune, K. (2018). Development of new method to enrich human iPSC-derived renal progenitors using cell surface markers. Scientific reports, 8(1), 6375.
 
Song, J., Janiszewski, A., De Geest, N., Vanheer, L., Talon, I., Oh, T., & Pasque, V. (2018). Two Active X-chromosomes Modulate the Growth, Pluripotency Exit and DNA Methylation Landscape of Mouse Naive Pluripotent Stem Cells through Different Pathways. bioRxiv, 291450.
*2i: CHIR99021 + PD0325901 from Axon Medchem
 
Mor, N., Rais, Y., Peles, S., Sheban, D., Aguilera-Castrejon, A., Zviran, A., ... & Hanna J. H. (2018). Neutralizing Gatad2a-Chd4-Mbd3 Axis within the NuRD complex facilitates deterministic induction of naive pluripotency.
*2i: CHIR99021 + PD0325901 from Axon Medchem
 
Ghimire, S., Van der Jeught, M., Neupane, J., Roost, M. S., Anckaert, J., Popovic, M., ... & Heindryckx, B. (2018). Comparative analysis of naive, primed and ground state pluripotency in mouse embryonic stem cells originating from the same genetic background. Scientific reports, 8(1), 5884.
 
Hsu, F., Spannl, S., Ferguson, C., Hyman, A. A., Parton, R. G., & Zerial, M. (2018). Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria. eLife, 7, e32282.
 
GOTOH, Shimpei, et al. Method for inducing differentiation of airway epithelial cells. U.S. Patent Application No 15/558,670, 2018.
 
van der Wal, E., Herrero-Hernandez, P., Wan, R., & Broeders, M. Stijn LM in’t Groen, Tom JM van Gestel, Wilfred FJ van IJcken, 5 Tom H. Cheung, 4 Ans T. van der Ploeg, 2, 3 Gerben J. Schaaf, and WWM Pim Pijnappel. Stem Cell Reports. 10, 1975–1990.
 
Lee, J., Matsuzawa, A., Shiura, H., Sutani, A., & Ishino, F. (2018). Preferable in vitro condition for maintaining faithful DNA methylation imprinting in mouse embryonic stem cells. Genes to Cells, 23(3), 146-160.
 
GOTOH, Shimpei, et al. Method for inducing differentiation of alveolar epithelial cells. U.S. Patent Application No 15/555,183, 2018.
 
Conic, S., Desplancq, D., Ferrand, A., Fischer, V., Heyer, V., San Martin, B. R., ... & Tora, L (2018). Imaging of native transcription factors and histone phosphorylation at high resolution in live cells. J. Cell Biol, 217(4), 1537-1552.
*2i: CHIR99021 + PD0325901 from Axon Medchem
 
Row, R. H., Pegg, A., Kinney, B. A., Farr 3rd, G. H., Maves, L., Lowell, S., ... & Martin, B. L. (2018). BMP and FGF signaling interact to pattern mesoderm by controlling basic helix-loop-helix transcription factor activity. Elife, 7, e31018.
 
木村瑞希. 細胞リプログラミングにおける WNT2/β‐catenin 経路の解析. 2018.
 
Sutherland, L., Ruhe, M., Gattegno-Ho, D., Mann, K., Greaves, J., Koscielniak, M., ... & Tsakiridis, A. (2018). LIF-dependent survival of embryonic stem cells is regulated by a novel palmitoylated Gab1 signalling protein. J Cell Sci, jcs-222257.
*2i: CHIR99021 + PD0325901 from Axon Medchem
 
Nett, I. R., Mulas, C., Gatto, L., Lilley, K. S., & Smith, A. (2018). Negative feedback via RSK modulates Erk‐dependent progression from naïve pluripotency. EMBO reports, e45642.
*CHIR99021, PD0325901, BI-D1870 from Axon Medchem
 
Lynch, CJ. Bernad, R, Calvo, I, Nobrega-Pereira, S, Ruiz, S, Ibarz, N, Martinez-Val, A. Gran-Castro, O, Gomez-Lopez, G, s-Leo´ n, EA, Angarica, VE, del Sol, A, Ortega, S, Fernandez-Capetillo, O.Rojo, E, Munoz, J and Serrano, M. The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity. Cell Reports 22, 2018, 396–410. 
*2i: CHIR99021 + PD0325901 from Axon Medchem
 
El-Saafin, F., Curry, C., Ye, T., Garnier, J. M., Kolb-Cheynel, I., Stierle, M., ... & Tora, L. (2018). Homozygous TAF8 mutation in a patient with intellectual disability results in undetectable TAF8 protein, but preserved RNA polymerase II transcription. Human molecular genetics, 27(12), 2171-2186.
*2i: CHIR99021 + PD0325901 from Axon Medchem
 
SATO, Toshiro; CLEVERS, Johannes C.; HUCH ORTEGA, Meritxell. CULTURE MEDIUM FOR EPITHELIAL STEM CELLS AND ORGANOIDS COMPRISING THE STEM CELLS. U.S. Patent Application No 15/654,243, 2018.
*2i: CHIR99021 + PD0325901 from Axon Medchem
 
Yamauchi, K., Li, J., Morikawa, K., Liu, L., Shirayoshi, Y., Nakatsuji, N., ... & Suemori, H. (2018). Isolation and characterization of ventricular-like cells derived from NKX2-5eGFP/w and MLC2vmCherry/w double knock-in human pluripotent stem cells. Biochemical and biophysical research communications, 495(1), 1278-1284.
 
Messemaker, T. C., Leeuwen, S. M., Berg, P. R., EJ‘t Jong, A., Palstra, R. J., Hoeben, R. C., ... & Mikkers, H. M. (2018). Allele-specific repression of Sox2 through the long non-coding RNA Sox2ot. Scientific reports, 8(1), 386.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Yoshimura, A., Adachi, N., Matsuno, H., Kawamata, M., Yoshioka, Y., Kikuchi, H., ... & Tamai, Y. (2018). The Sox2 promoter-driven CD63-GFP transgenic rat model allows tracking of neural stem cell-derived extracellular vesicles. Disease models & mechanisms, 11(1), dmm028779.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Toyoshima, H., Okazaki, Y., Yokoo, T., & Sugahara, I. (2018). Peptide and application thereof. U.S. Patent No. 9,856,304. Washington, DC: U.S. Patent and Trademark Office.
 
Katayama, M., Hirayama, T., Tani, T., Nishimori, K., Onuma, M., & Fukuda, T. (2018). Chick derived induced pluripotent stem cells by the poly‐cistronic transposon with enhanced transcriptional activity. Journal of cellular physiology, 233(2), 990-1004.
 
Jovanovic, V. M., Salti, A., Tilleman, H., Zega, K., Jukic, M. M., Zou, H., ... & Brodski, C. (2018). BMP/SMAD pathway promotes neurogenesis of midbrain dopaminergic neurons in vivo and in human induced pluripotent and neural stem cells. Journal of Neuroscience, 38(7), 1662-1676.
 
Sagner, A., Gaber, Z. B., Delile, J., Kong, J. H., Rousso, D. L., Pearson, C. A., ... & Novitch, B. G. (2018). Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics. PLoS biology, 16(2), e2003127.
 
Yu, Y., Wang, X., Zhang, X., Zhai, Y., Lu, X., Ma, H., ... & Li, L. (2018). ERK inhibition promotes neuroectodermal precursor commitment by blocking self-renewal and primitive streak formation of the epiblast. Stem cell research & therapy, 9(1), 2.
 
Zhu, H., Kimura, T., Swami, S., & Wu, J. Y. (2018). Pluripotent stem cells as a source of osteoblasts for bone tissue regeneration. Biomaterials.
 
Angarica, V. E., del Sol, A., Ortega, S., Fernandez-Capetillo, O., Rojo, E., Munoz, J., & Serrano, M. The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Mor, N., Rais, Y., Peles, S., Sheban, D., Aguilera-Castrejon, A., Zviran, A., ... & Zerbib, M. (2018). Neutralizing Gatad2a-Chd4-Mbd3 Axis within the NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency. bioRxiv, 192781.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
SR Braam, F STEVENHAGEN. Assays for measuring cardiotoxicity. US Patent App. 15/552,333, 2018
 
K.F. Sonnen, V.M. Lauschke, J. Uraji, H.J. Falk, Y. Petersen, M.C.Funk, M. Beaupeux, P. François, C.A. Merten, A. Aulehla. (2018). Modulation of Phase Shift between Wnt and Notch Signaling Oscillations Controls Mesoderm Segmentation.
Cell, 2018, 172(5), 1079-1090.e12
 
Peruzzotti-Jametti, L., Bernstock, J. D., Vicario, N., Costa, A. S., Kwok, C. K., Leonardi, T., ... & Mallucci, G. (2018). Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation. Cell Stem Cell.
 
Yamauchi, K., Li, J., Morikawa, K., Liu, L., Shirayoshi, Y., Nakatsuji, N., ... & Suemori, H. (2018). Isolation and characterization of ventricular-like cells derived from NKX2-5eGFP/w and MLC2vmCherry/w double knock-in human pluripotent stem cells. Biochemical and biophysical research communications, 495(1), 1278-1284.
 
Messemaker, T. C., Leeuwen, S. M., Berg, P. R., EJ‘t Jong, A., Palstra, R. J., Hoeben, R. C., ... & Mikkers, H. M. (2018). Allele-specific repression of Sox2 through the long non-coding RNA Sox2ot. Scientific reports, 8(1), 386.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Yoshimura, A., Adachi, N., Matsuno, H., Kawamata, M., Yoshioka, Y., Kikuchi, H., ... & Tamai, Y. (2018). The Sox2 promoter-driven CD63-GFP transgenic rat model allows tracking of neural stem cell-derived extracellular vesicles. Disease models & mechanisms, 11(1), dmm028779.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Kilens, S., Meistermann, D., Moreno, D., Chariau, C., Gaignerie, A., Reignier, A., ... & Flippe, L. (2018). Parallel derivation of isogenic human primed and naive induced pluripotent stem cells. Nature communications, 9(1), 360.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Toyoshima, H., Okazaki, Y., Yokoo, T., & Sugahara, I. (2018). Peptide and application thereof. U.S. Patent No. 9,856,304. Washington, DC: U.S. Patent and Trademark Office.
 
Pfeiffer, M. J., Quaranta, R., Piccini, I., Fell, J., Rao, J., Röpke, A., ... & Greber, B. (2018). Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES. Nature communications, 9(1), 440.
 
Katayama, M., Hirayama, T., Tani, T., Nishimori, K., Onuma, M., & Fukuda, T. (2018). Chick derived induced pluripotent stem cells by the poly‐cistronic transposon with enhanced transcriptional activity. Journal of cellular physiology, 233(2), 990-1004.
 
Jovanovic, V. M., Salti, A., Tilleman, H., Zega, K., Jukic, M. M., Zou, H., ... & Brodski, C. (2018). BMP/SMAD pathway promotes neurogenesis of midbrain dopaminergic neurons in vivo and in human induced pluripotent and neural stem cells. Journal of Neuroscience, 38(7), 1662-1676.
 
Sagner, A., Gaber, Z. B., Delile, J., Kong, J. H., Rousso, D. L., Pearson, C. A., ... & Novitch, B. G. (2018). Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics. PLoS biology, 16(2), e2003127.
 
Yu, Y., Wang, X., Zhang, X., Zhai, Y., Lu, X., Ma, H., ... & Li, L. (2018). ERK inhibition promotes neuroectodermal precursor commitment by blocking self-renewal and primitive streak formation of the epiblast. Stem cell research & therapy, 9(1), 2.
 
Zhu, H., Kimura, T., Swami, S., & Wu, J. Y. (2018). Pluripotent stem cells as a source of osteoblasts for bone tissue regeneration. Biomaterials.
 
de Jesus, B. B., Marinho, S. P., Barros, S., Sousa-Franco, A., Alves-Vale, C., Carvalho, T., & Carmo-Fonseca, M. (2018). Silencing of the lncRNA Zeb2-NAT facilitates reprogramming of aged fibroblasts and safeguards stem cell pluripotency. Nature communications, 9(1), 94.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Angarica, V. E., del Sol, A., Ortega, S., Fernandez-Capetillo, O., Rojo, E., Munoz, J., & Serrano, M. The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Mor, N., Rais, Y., Peles, S., Sheban, D., Aguilera-Castrejon, A., Zviran, A., ... & Zerbib, M. (2018). Neutralizing Gatad2a-Chd4-Mbd3 Axis within the NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency. bioRxiv, 192781.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
SR Braam, F STEVENHAGEN. Assays for measuring cardiotoxicity. US Patent App. 15/552,333, 2018
 
2017  (77 citations)
HIRABAYASHI, M., HARA, H., GOTO, T., TAKIZAWA, A., DWINELL, M. R., YAMANAKA, T., ... & NAKAUCHI, H. (2017). Haploid embryonic stem cell lines derived from androgenetic and parthenogenetic rat blastocysts. Journal of Reproduction and Development, 63(6), 611-616.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Osafune, K., & Toyoda, T. (2017). Method for producing pancreatic blast cells and pancreatic disease treatment agent containing pancreatic blast cells. U.S. Patent Application No. 15/311,759.
 
Trixl, L., Amort, T., Wille, A., Zinni, M., Ebner, S., Hechenberger, C., ... & Piatti, P. (2017). RNA cytosine methyltransferase Nsun3 regulates embryonic stem cell differentiation by promoting mitochondrial activity. Cellular and Molecular Life Sciences, 1-15.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Yoshimura, A., Adachi, N., Matsuno, H., Kawamata, M., Yoshioka, Y., Kikuchi, H., ... & Tamai, Y. (2018). The Sox2 promoter-driven CD63-GFP transgenic rat model allows tracking of neural stem cell-derived extracellular vesicles. Disease models & mechanisms, 11(1), dmm028779.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Messemaker, T. C., Leeuwen, S. M., Berg, P. R., EJ‘t Jong, A., Palstra, R. J., Hoeben, R. C., ... & Mikkers, H. M. (2018). Allele-specific repression of Sox2 through the long non-coding RNA Sox2ot. Scientific reports, 8(1), 386.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Fitzgerald, J. C., Zimprich, A., Carvajal Berrio, D. A., Schindler, K. M., Maurer, B., Schulte, C., ... & Bobbili, D. R. (2017). Metformin reverses TRAP1 mutation-associated alterations in mitochondrial function in Parkinson’s disease. Brain, 140(9), 2444-2459.
 
Tang, L., Su, J., & Liang, P. (2017). Modeling cadmium-induced endothelial toxicity using human pluripotent stem cell-derived endothelial cells. Scientific reports, 7(1), 14811.
*CHIR99021 and IWR-1 from Axon Medchem
 
Pusapati, G. V., Kong, J. H., Patel, B. B., Krishnan, A., Sagner, A., Kinnebrew, M., ... & Rohatgi, R. (2017). CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog. Developmental cell.
*PD98059 and CHIR99021 from Axon Medchem
 
Raab, S., Klingenstein, M., Möller, A., Illing, A., Tosic, J., Breunig, M., ... & Kleger, A. (2017). Reprogramming to pluripotency does not require transition through a primitive streak-like state. Scientific reports, 7(1), 16543.
 
Karg, E., Smets, M., Ryan, J., Forné, I., Qin, W., Mulholland, C. B., ... & Leonhardt, H. (2017). Ubiquitome Analysis Reveals PCNA-Associated Factor 15 (PAF15) as a Specific Ubiquitination Target of UHRF1 in Embryonic Stem Cells. Journal of molecular biology, 429(24), 3814-3824.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Matsuo, K., Sone, M., Honda-Kohmo, K., Toyohara, T., Sonoyama, T., Taura, D., ... & Ohta, A. (2017). Significance of dopamine D 1 receptor signalling for steroidogenic differentiation of human induced pluripotent stem cells. Scientific reports, 7(1), 15120.
 
WANG, Jichang; IZSVÁK, Zsuzsanna; HURST, Laurence Daniel. Endogenous retrovirus transcription as a marker for primate naive pluripotent stem cells. U.S. Patent Application No 15/517,904, 2017.
*CHIR99021, PD0325901, SB2020190
 
TOYOSHIMA, Hideo, et al. Peptide and application thereof. U.S. Patent No 9,856,304, 2018.
 
Yamamoto, Y., Gotoh, S., Korogi, Y., Seki, M., Konishi, S., Ikeo, S., ... & Ito, I. (2017). Long-term expansion of alveolar stem cells derived from human iPS cells in organoids. Nature methods, 14(11), 1097.
 
BRAAM, Stefan Robbert; TEROOLEN, Leon; MUMMERY, Christine. Cardiomyocyte maturation. U.S. Patent Application No 15/316,341, 2017.
 
HASEGAWA, Kouichi, et al. Culture medium for pluripotent stem cells. U.S. Patent Application No 15/128,747, 2017.
 
Alzubi, J., Pallant, C., Mussolino, C., Howe, S. J., Thrasher, A. J., & Cathomen, T. (2017). Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model. Scientific Reports, 7(1), 12475.
 
Jacobs, E. Z., Warrier, S., Volders, P. J., D’haene, E., Van Lombergen, E., Vantomme, L., ... & Vergult, S. (2017). CRISPR/Cas9-mediated genome editing in naïve human embryonic stem cells. Scientific reports, 7(1), 16650.
 
de Jesus, B. B., Marinho, S. P., Barros, S., Sousa-Franco, A., Alves-Vale, C., Carvalho, T., & Carmo-Fonseca, M. (2018). Silencing of the lncRNA Zeb2-NAT facilitates reprogramming of aged fibroblasts and safeguards stem cell pluripotency. Nature communications, 9(1), 94.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
HANNA, Yaqub; NOVERSHTERN, Noa; RAIS, Yoach. Media for culturing pluripotent stem cells. U.S. Patent Application No 15/500,163, 2017.
*CHIR99021, BIO, PD0325901, PD98059, PD184352, BAY43-9006, Thiazovivin, CGP77675, DAPT, DBZ, LY2886762, RU-SKI43, LDN193189, K02288, Dosomorphine, BIRB796, AEG3482, SB203580, SB202190, LY 2228820, PD169316 etc. from Axon Medchem
 
Braet, H. (2017). ANALYSIS OF THE GENOMIC STABILITY OF HUMAN EMBRYONIC STEM CELLS IN DIFFERENT STATES OF PLURIPOTENCY (Doctoral dissertation, Ghent University).
*CHIR99021 and BIR796 from Axon Medchem
 
SCHOELER, Hans R., et al. Mammalian neural plate border stem cells capable of forming neural tube and neural crest cell lineages including central and peripheral neurons. U.S. Patent Application No 15/233,561, 2017.
 
Katsuda, T., Hosaka, K., & Ochiya, T. (2017). Generation of Chemically Induced Liver Progenitors (CLiPs) from Rat Adult Hepatocytes. Cell Stem Cell.
 
Lee, J., Matsuzawa, A., Shiura, H., Sutani, A., & Ishino, F. (2018). Preferable in vitro condition for maintaining faithful DNA methylation imprinting in mouse embryonic stem cells. Genes to Cells.
 
VUNJAK-NOVAKOVIC, Gordana, et al. Engineered adult-like human heart tissue. U.S. Patent Application No 15/151,751, 2017.
 
ORTEGA, Meritxell Huch; CLEVERS, Johannes Carolus. Liver organoid, uses thereof and culture method for obtaining them. U.S. Patent No 9,765,301, 2017.
*2i: CHIR99021 and PD0325901 from Axon Medchem

Warrier, S., Van der Jeught, M., Duggal, G., Tilleman, L., Sutherland, E., Taelman, J., ... & Peelman, L. (2017). Direct comparison of distinct naive pluripotent states in human embryonic stem cells. Nature Communications, 8: 15055.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413953/

Hohwieler, M., Illing, A., Hermann, P. C., Mayer, T., Stockmann, M., Perkhofer, L., ... & Kuo, C. C. (2017). Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling. Gut, 66(3), 473-486.
See: http://gut.bmj.com/content/66/3/473
*Chir99021 and SB431542 from Axon Medchem

Yamaguchi, T., Sato, H., Kato-Itoh, M., Goto, T., Hara, H., Sanbo, M., ... & Ota, Y. (2017). Interspecies organogenesis generates autologous functional islets. Nature, 542(7640), 191-196.
https://www.nature.com/nature/journal/v542/n7640/abs/nature21070.html
*2i: CHIR99021 and PD0325901 from Axon Medchem

Kawamata, M., Katsuda, T., Yamada, Y., & Ochiya, T. (2017). In vitro reconstitution of breast cancer heterogeneity with multipotent cancer stem cells using small molecules. Biochemical and Biophysical Research Communications, 482(4), 750-757.
See: http://www.sciencedirect.com/science/article/pii/S0006291X16319805
*2i: CHIR99021 and PD0325901 from Axon Medchem

Nigro, A. L., Prosper, F., & Aranguren, X. L. (2017). Generation of a Sprague-Dawley-GFP rat iPS cell line. Stem Cell Research. 2017, 21, 47-50.
https://www.researchgate.net/profile/Antonio_Lo_Nigro/publication/316029625_Generation_of_a_Sprague-Dawley-GFP_rat_iPS_cell_line/links/58f770f6aca272649886fda3/Generation-of-a-Sprague-Dawley-GFP-rat-iPS-cell-line.pdf
*2i: CHIR99021 and PD0325901 from Axon Medchem

Stryjewska, A., Dries, R., Pieters, T., Verstappen, G., Conidi, A., Coddens, K., ... & van Grunsven, L. A. (2017). Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse Embryonic Stem Cells. Stem Cells, 35(3), 611-625.
See: http://onlinelibrary.wiley.com/doi/10.1002/stem.2521/full
*2i: CHIR99021 and PD0325901 from Axon Medchem

Coppiello, G., Abizanda, G., Aguado, N., Iglesias, E., Iglesias-Garcia, O., Nigro, A. L., ... & Aranguren, X. L. (2017). Generation of a Sprague-Dawley-GFP rat iPS cell line. Stem Cell Research. 21, 40-43.
See: http://www.sciencedirect.com/science/article/pii/S187350611730065X
*2i: CHIR99021 and PD0325901 from Axon Medchem

Coppiello, G., Abizanda, G., Aguado, N., Iglesias, E., Iglesias-Garcia, O., Nigro, A. L., ... & Aranguren, X. L. (2017). Isolation and characterization of Sprague-Dawley and Wistar Kyoto GFP rat embryonic stem cells. Stem Cell Research. 21, 47-50.
See: http://www.sciencedirect.com/science/article/pii/S1873506117300648
*2i: CHIR99021 and PD0325901 from Axon Medchem

Yang, S., Ding, S., Xu, Q., Li, X., & Xiong, Q. (2017). Genetic Manipulation by Zinc-Finger Nucleases in Rat-Induced Pluripotent Stem Cells. Cellular Reprogramming (Formerly" Cloning and Stem Cells"). 19(3): 180-188.
See: http://online.liebertpub.com/doi/abs/10.1089/cell.2016.0028

Yoshimura, Y., Taguchi, A., & Nishinakamura, R. (2017). Generation of a Three-Dimensional Kidney Structure from Pluripotent Stem Cells. Organ Regeneration: 3D Stem Cell Culture & Manipulation, 179-193.
See: https://link.springer.com/protocol/10.1007/978-1-4939-6949-4_13

Kwok, C. K., Ueda, Y., Kadari, A., Günther, K., Heron, A., Schnitzler, A. C., ... & Edenhofer, F. (2017). Scalable stirred suspension culture for the generation of billions of human induced pluripotent stem cells using single‐use bioreactors. Journal of Tissue Engineering and Regenerative Medicine.
See: http://onlinelibrary.wiley.com/doi/10.1002/term.2435/full

Hosokawa, Y., Toyoda, T., Fukui, K., Baden, M. Y., Funato, M., Kondo, Y., ... & Watanabe, A. (2017). Insulin‐producing cells derived from ‘induced pluripotent stem cells’ of patients with fulminant type 1 diabetes: vulnerability to cytokine insults and increased expression of apoptosis‐related genes. Journal of Diabetes Investigation. DOI: 10.1111/jdi.12727
http://onlinelibrary.wiley.com/doi/10.1111/jdi.12727/full

Tosti, L., Ashmore, J., Tan, B. S. N., Carbone, B., Mistri, T. K., Wilson, V., ... & Kaji, K. (2017). Mapping transcription factor occupancy using minimal numbers of cells in vitro and in vivo. bioRxiv, 158931.
http://www.biorxiv.org/content/early/2017/07/03/158931.full.pdf+html
*2i: CHIR99021 and PD0325901 from Axon Medchem

Ludwig, A. K., Zhang, P., Hastert, F. D., Meyer, S., Rausch, C., Herce, H. D., ... & Storm, C. (2017). Binding of MBD proteins to DNA blocks Tet1 function thereby modulating transcriptional noise. Nucleic acids research, 45(5), 2438-2457.
https://academic.oup.com/nar/article/45/5/2438/2638395/Binding-of-MBD-proteins-to-DNA-blocks-Tet1
*2i: CHIR99021 and PD0325901 from Axon Medchem*

Pieters, T., Haenebalcke, L., Bruneel, K., Vandamme, N., Hochepied, T., van Hengel, J., ... & Goossens, S. (2017). Structure-function Studies in Mouse Embryonic Stem Cells Using Recombinase-mediated Cassette Exchange. JoVE (Journal of Visualized Experiments), (122), e55575-e55575.
https://www.jove.com/video/55575/structure-function-studies-mouse-embryonic-stem-cells-using
*2i: CHIR99021 and PD0325901 from Axon Medchem

Zhang, P., Rausch, C., Hastert, F. D., Boneva, B., Filatova, A., Patil, S. J., ... & Cardoso, M. C. (2017). Methyl-CpG binding domain protein 1 regulates localization and activity of Tet1 in a CXXC3 domain-dependent manner. Nucleic Acids Research.
https://academic.oup.com/nar/article/3752492
*2i: CHIR99021 and PD0325901 from Axon Medchem

Ziegenhain, C., Vieth, B., Parekh, S., Reinius, B., Guillaumet-Adkins, A., Smets, M., ... & Enard, W. (2017). Comparative analysis of single-cell RNA sequencing methods. Molecular cell, 65(4), 631-643.
http://www.sciencedirect.com/science/article/pii/S1097276517300497
*2i: CHIR99021 and PD0325901 from Axon Medchem

Monzel, A. S., Smits, L. M., Hemmer, K., Hachi, S., Moreno, E. L., van Wuellen, T., ... & Berger, E. (2017). Derivation of human midbrain-specific organoids from neuroepithelial Stem Cells. Stem cell reports, 8(5), 1144-1154.
http://www.sciencedirect.com/science/article/pii/S2213671117301169

Katsuda, T., Kawamata, M., Hagiwara, K., Takahashi, R. U., Yamamoto, Y., Camargo, F. D., & Ochiya, T. (2017). Conversion of terminally committed hepatocytes to culturable bipotent progenitor cells with regenerative capacity. Cell stem cell, 20(1), 41-55.
http://www.sciencedirect.com/science/article/pii/S1934590916303472
*2i: CHIR99021 and PD0325901 from Axon Medchem

Cirelli, E., De Domenico, E., Botti, F., Massoud, R., Geremia, R., & Grimaldi, P. (2017). Effect Of Microgravity On Aromatase Expression In Sertoli Cells. Scientific Reports, 2017; 7: 3469.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471225/

Böscke, R., Vladar, E. K., Könnecke, M., Hüsing, B., Linke, R., Pries, R., ... & Wollenberg, B. (2017). Wnt Signaling in Chronic Rhinosinusitis with Nasal Polyps. American journal of respiratory cell and molecular biology, 56(5), 575-584.
http://www.atsjournals.org/doi/abs/10.1165/rcmb.2016-0024OC

KATAYAMA, M., HIRAYAMA, T., KIYONO, T., ONUMA, M., TANI, T., TAKEDA, S., ... & FUKUDA, T. (2017). Immortalized prairie vole-derived fibroblasts (VMF-K4DTs) can be transformed into pluripotent stem cells and provide a useful tool with which to determine optimal reprogramming conditions. Journal of Reproduction and Development, 2016-164.
https://www.jstage.jst.go.jp/article/jrd/advpub/0/advpub_2016-164/_article

A.S. Monzel, L.M. Smits, K. Hemmer, S. Hachi, E. L. Moreno,
T. van Wuellen, J. Jarazo, J. Walter, I. Bruggemann, I Boussaad, E. Berger,
R. M. Fleming, S. Bolognin, and J. C. Schwamborn. Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells. Stem Cell Reports. 2017, 8, 1144–1154.
http://www.cell.com/stem-cell-reports/pdfExtended/S2213-6711(17)30116-9

Anton, T., & Bultmann, S. (2017). Site-specific recruitment of epigenetic factors with a modular CRISPR/Cas system. Nucleus, 1-8.
http://www.tandfonline.com/doi/full/10.1080/19491034.2017.1292194?scroll=top&needAccess=true
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Hirsch, C., Striegl, B., Mathes, S., Adlhart, C., Edelmann, M., Bono, E., ... & Nyffeler, J. (2017). Multiparameter toxicity assessment of novel DOPO-derived organophosphorus flame retardants. Archives of toxicology, 91(1), 407-425.
https://link.springer.com/article/10.1007/s00204-016-1680-4

Katayama, M., Hirayama, T., Tani, T., Nishimori, K., Onuma, M., & Fukuda, T. (2017). Chick derived induced pluripotent stem cells by the poly‐cistronic transposon with enhanced transcriptional activity. Journal of Cellular Physiology.
http://onlinelibrary.wiley.com/doi/10.1002/jcp.25947/full

van der Wal, E., Bergsma, A. J., van Gestel, T. J., LM, S., Zaehres, H., Araúzo-Bravo, M. J., ... & Pijnappel, W. P. (2017). GAA Deficiency in Pompe Disease Is Alleviated by Exon Inclusion in iPSC-Derived Skeletal Muscle Cells. Molecular Therapy-Nucleic Acids, 7, 101-115.
http://www.sciencedirect.com/science/article/pii/S2162253117301403

Murakami, N., Imamura, K., Izumi, Y., Egawa, N., Tsukita, K., Enami, T., ... & Inoue, H. (2017). Proteasome impairment in neural cells derived from HMSN-P patient iPSCs. Molecular brain, 10(1), 7.
https://molecularbrain.biomedcentral.com/articles/10.1186/s13041-017-0286-y

Ehrlich, M., Mozafari, S., Glatza, M., Starost, L., Velychko, S., Hallmann, A. L., ... & Marteyn, A. (2017). Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors. Proceedings of the National Academy of Sciences, 114(11), E2243-E2252.
http://www.pnas.org/content/114/11/E2243.short

Gotoh, S. Generation of Alveolar Epithelial Spheroids via Isolated. Am. J. Physiol, 258, L134-L147.
https://pdfs.semanticscholar.org/2dba/7ce947c65034d6ddd0007013f4785cc624af.pdf

Giacomelli, E., Bellin, M., Sala, L., Van Meer, B. J., Tertoolen, L. G., Orlova, V. V., & Mummery, C. L. (2017). Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells. Development, dev-143438.
http://dev.biologists.org/content/develop/early/2017/03/08/dev.143438.full.pdf

Gouti, M., Delile, J., Stamataki, D., Wymeersch, F. J., Huang, Y., Kleinjung, J., ... & Briscoe, J. (2017). A gene regulatory network balances neural and mesoderm specification during vertebrate trunk development. Developmental Cell, 41(3), 243-261.
http://www.sciencedirect.com/science/article/pii/S1534580717302952

Hoffmann, D., Schott, J. W., Geis, F. K., Lange, L., Müller, F. J., Lenz, D., ... & Schambach, A. (2017). Detailed comparison of retroviral vectors and promoter configurations for stable and high transgene expression in human induced pluripotent stem cells. Gene Therapy, 24(5), 298-307.
https://www.nature.com/gt/journal/v24/n5/abs/gt201720a.html

Nguyen, T. P., & Sieg, S. F. (2017). TGF-β inhibits IL-7-induced proliferation in memory but not naive human CD4+ T cells. Journal of Leukocyte Biology, jlb-3A1216.
http://www.jleukbio.org/content/early/2017/06/05/jlb.3A1216-520RR.abstract

Barakat, T. S., Halbritter, F., Zhang, M., Rendeiro, A. F., Bock, C., & Chambers, I. (2017). Functional dissection of the enhancer repertoire in human embryonic stem cells. bioRxiv, 146696.
http://www.biorxiv.org/content/early/2017/07/04/146696.full.pdf+html
*2i: CHIR99021 and PD0325901 from Axon Medchem

Chal, J., Al Tanoury, Z., Oginuma, M., Moncuquet, P., Gobert, B., Miyanari, A., ... & Garnier, J. M. (2017). Recapitulating Early Development Of Mouse Musculoskeletal Precursors Of The Paraxial Mesoderm In Vitro. bioRxiv, 140574.
http://www.biorxiv.org/content/early/2017/05/22/140574
* CHIR99021 and LDN193189 from Axon Medchem

Thanisch, K., Song, C., Engelkamp, D., Koch, J., Wang, A., Hallberg, E., ... & Solovei, I. (2017). Nuclear envelope localization of LEMD2 is developmentally dynamic and lamin A/C dependent yet insufficient for heterochromatin tethering. Differentiation, 94, 58-70.
http://www.sciencedirect.com/science/article/pii/S0301468116301116
*2i: CHIR99021 and PD0325901 from Axon Medchem

Dierickx, P., Vermunt, M. W., Muraro, M. J., Creyghton, M. P., Doevendans, P. A., van Oudenaarden, A., ... & Van Laake, L. W. (2017). Circadian networks in human embryonic stem cell‐derived cardiomyocytes. EMBO reports, e201743897.
http://www.sciencedirect.com/science/article/pii/S2213671116303009
*2i: CHIR99021 and PD0325901 from Axon Medchem

Nakatsuji, N., Minami, I., Uesugi, M., & Aiba, K. (2017). U.S. Patent No. 9,587,220. Washington, DC: U.S. Patent and Trademark Office.
http://embor.embopress.org/content/early/2017/05/23/embr.201743897?utm_source=TrendMD&utm_medium=cpc&utm_campaign=EMBO_Rep_TrendMD_0

A. L. Nigro,* A. de Jaime-Soguero, R. Khoueiry, D. S. Cho, G. M. Ferlazzo, I. Perini, V. A. Escalona, X. L. Aranguren, S.M.C. de Sousa Lopes, K. P. Koh, P. Giulio Conaldi, W.-S. Hu, A. Zwijsen, F. Lluis, & C.M. Verfaillie.
PDGFRa+ Cells in Embryonic Stem Cell Cultures Represent the In Vitro Equivalent of the Pre-implantation Primitive Endoderm Precursors.
http://www.cell.com/stem-cell-reports/pdfExtended/S2213-6711(16)30300-9
*2i: CHIR99021 and PD0325901 from Axon Medchem

Zhang, P., Ludwig, A. K., Hastert, F. D., Rausch, C., Lehmkuhl, A., Hellmann, I., ... & Cardoso, M. C. (2017). L1 retrotransposition is activated by Ten-eleven-translocation protein 1 and repressed by methyl-CpG binding proteins. Nucleus, (May 2017 accepted), 1-15.
http://www.tandfonline.com/doi/abs/10.1080/19491034.2017.1330238
*2i: CHIR99021 and PD0325901 from Axon Medchem

Amort, T., Rieder, D., Wille, A., Khokhlova-Cubberley, D., Riml, C., Trixl, L., ... & Lusser, A. (2017). Distinct 5-methylcytosine profiles in poly (A) RNA from mouse embryonic stem cells and brain. Genome biology, 18(1), 1.
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1139-1
*2i: CHIR99021 and PD0325901 from Axon Medchem

Uliassi, E., Gandini, A., Perone, R. C., & Bolognesi, M. L. (2017). Neuroregeneration versus neurodegeneration: toward a paradigm shift in Alzheimer's disease drug discovery.
https://www.future-science.com/doi/abs/10.4155/fmc-2017-0038

Kondo, Y., Toyoda, T., Ito, R., Funato, M., Hosokawa, Y., Matsui, S., ... & Watanabe, A. (2017). Identification of a small molecule that facilitates the differentiation of human iPSCs/ESCs and mouse embryonic pancreatic explants into pancreatic endocrine cells. Diabetologia, 1-13.
https://link.springer.com/article/10.1007/s00125-017-4302-7

Ashida, Y., Nakajima‐Koyama, M., Hirota, A., Yamamoto, T., & Nishida, E. (2017). Activin A in combination with ERK1/2 MAPK pathway inhibition sustains propagation of mouse embryonic stem cells. Genes to Cells, 22(2), 189-202.
http://onlinelibrary.wiley.com/doi/10.1111/gtc.12467/full

Glover, J. D., Wells, K. L., Matthäus, F., Painter, K. J., Ho, W., Riddell, J., ... & Mort, R. L. (2017). Hierarchical patterning modes orchestrate hair follicle morphogenesis. PLoS biology, 15(7), e2002117.
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2002117

Marczenke, M., Piccini, I., Mengarelli, I., Fell, J., Röpke, A., Seebohm, G., ... & Greber, B. (2017). Cardiac Subtype-Specific Modeling of Kv1. 5 Ion Channel Deficiency Using Human Pluripotent Stem Cells. Frontiers in Physiology, 8.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498524/

Drouin‐Ouellet, J., Lau, S., Brattås, P. L., Ottosson, D. R., Pircs, K., Grassi, D. A., ... & Graff, C. (2017). REST suppression mediates neural conversion of adult human fibroblasts via microRNA‐dependent and‐independent pathways. EMBO molecular medicine, 9(8), 1117-1131.
http://embomolmed.embopress.org/content/9/8/1117
*CHIR99021, SB431542 and LDN193189 from Axon Medchem

Dierickx, P., Vermunt, M. W., Muraro, M. J., Creyghton, M. P., Doevendans, P. A., van Oudenaarden, A., ... & Van Laake, L. W. (2017). Circadian networks in human embryonic stem cell‐derived cardiomyocytes. EMBO reports, e201743897.
http://embor.embopress.org/content/early/2017/05/23/embr.201743897?utm_source=TrendMD&utm_medium=cpc&utm_campaign=EMBO_Rep_TrendMD_0

Jason, J. Y., Paranjape, S. R., Walker, M. P., Choudhury, R., Wolter, J. M., Fragola, G., ... & Zylka, M. J. (2017). The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome. Journal of Biological Chemistry, jbc-M117.
http://www.jbc.org/content/early/2017/05/30/jbc.M117.788448.short

Yi, J. J., Paranjape, S. R., Walker, M. P., Choudhury, R., Wolter, J. M., Fragola, G., ... & Zylka, M. J. (2017).
The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome.
JBC Papers in Press. Published on May 30, 2017 as Manuscript M117. 788448.
https://www.researchgate.net/publication/317261376_The_autism-linked_UBE3A_T485A_mutant_E3_ubiquitin_ligase_activates_the_Wntb-catenin_pathway_by_inhibiting_the_proteasome

2016 (66 citations)
Sancho-Martinez, Ignacio, et al. "Establishment of human iPSC-based models for the study and targeting of glioma initiating cells." Nature communications 7 (2016).

http://www.nature.com/ncomms/2016/160222/ncomms10743/full/ncomms10743.html
2i CHIR99021 and PD0325901 were from Axon Medchem. 

Matsuno, Kunihiko, et al. "Redefining definitive endoderm subtypes by robust induction of human induced pluripotent stem cells." Differentiation (2016).
http://www.sciencedirect.com/science/article/pii/S0301468116300238
*CHIR99021 and LDN193189 were purchased from Axon Medchem.

Meek, Stephen, et al. "Reduced levels of dopamine and altered metabolism in brains ofHPRTknock-out rats: a new rodent model of Lesch-Nyhan Disease." Scientific reports 6 (2016): 25592.
http://www.nature.com/articles/srep25592
2i:CHIR99021 and PD0325901 were purchased from Axon Medchem 

Vrij, Erik, et al. "Directed Assembly and Development of Material‐Free Tissues with Complex Architectures." Advanced Materials (2016).
http://onlinelibrary.wiley.com/doi/10.1002/adma.201505723/full 

Becker, Matthias, et al. "Polycomb proteinBMI1 regulates osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells downstream of GSK3." Stem cells and development (2016).
http://online.liebertpub.com/doi/abs/10.1089/scd.2015.0277 

Sudheer, Smita, et al. "Different Concentrations of FGF Ligands, FGF2 or FGF8 Determine Distinct States of WNT‐Induced Presomitic Mesoderm."STEMCELLS (2016).
http://onlinelibrary.wiley.com/doi/10.1002/stem.2371/abstract
2i:CHIR99021 and PD0325901 were from Axon Medchem. 

Kugler, Josephine, et al. "Identification and characterization of teratogenic chemicals using embryonic stem cells isolated from a Wnt/β-Catenin-reporter transgenic mouse line." Toxicological Sciences (2016): kfw094.
http://toxsci.oxfordjournals.org/content/early/2016/05/19/toxsci.kfw094.abstract
*CHIR99021 and XAV939 from Axon Medchem

Huang, Jijun, et al. "Coupling switch of P2Y-IP3 receptors mediates differential Ca2+ signaling in human embryonic stem cells and derived cardiovascular progenitor cells." Purinergic signalling (2016): 1-14.
http://link.springer.com/article/10.1007/s11302-016-9512-9

Rivron, Nicolas Clément, et al. "BLASTOID,CELLLINEBASED ARTIFICIAL BLASTOCYST."U.S.Patent No. 20,160,060,593.3 Mar. 2016.
http://www.freepatentsonline.com/y2016/0060593.html 

Den Hartogh, Sabine C. "Fluorescent gene reporters in human pluripotent stem cells: as model for studying human heart development and cardiomyocyte differentiation." (2016).
https://openaccess.leidenuniv.nl/handle/1887/39677 

Braam, Stefan Robbert. "CULTURE MEDIUM COMPOSITION FOR MATURATING CARDIOMYOCYTES DERIVED FROM PLURIPOTENT MAMMALIANSTEMCELLS."U.S.Patent No. 20,160,122,718. 5 May 2016.
http://www.freepatentsonline.com/y2016/0122718.html 

Hara, Hiromasa, et al. "Rat Blastocysts from Nuclear Infection and Time-Lagged Enucleation and Their Commitment to Embryonic Stem Cells." Cellular Reprogramming (Formerly" Cloning and Stem Cells") 18.2 (2016): 108-115.
http://online.liebertpub.com/doi/abs/10.1089/cell.2015.0084

V Schwach et al. Generation and purification of human stem cell-derived cardiomyocytes.
Differentiation. 2016 Feb 22. pii: S0301-4681(16)30002-0.

H Neumann et al. Polysialic acid and use for treatment of neurodegenerative and neuroinflammatory diseases.
U.S. Patent 20,160,046,734.
(CHIR99021, SB431542 and Compound E(BZ) from Axon Medchem)

C Hirsch et al. Multiparameter toxicity assessment of novel DOPO-derived organophosphorus flame retardants.
Arch Toxicol. 2016 Feb 29. [Epub ahead of print]
(2i:CHIR99021 and PD0325901 from Axon Medchem)

M Naujock et al. 4-Aminopyridine Induced Activity Rescues Hypoexcitable Motor Neurons from ALSPatient-Derived Induced Pluripotent Stem Cells.
Stem Cells. 2016 Mar 6. [Epub ahead of print]

J. Wang et al. Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression. 
Nat Protoc. 2016 Feb;11(2):327-46.
(2i:CHIR99021 and PD0325901 from Axon Medchem)

B. Linnartz‐Gerlachet al. Sialylation of neurites inhibits complement‐mediated macrophage removal in a human macrophage‐neuron Co‐Culture System.
Glia. 2016 Jan;64(1):35-47.
(CHIR99021 and SB431542 from Axon Medchem) 

N. Nakatsuji et al. COMPOSITION FOR PROMOTING CARDIAC DIFFERENTIATION OF PLURIPOTENT STEMCELLCOMPRISING EGFR INHIBITOR.
U.S. Patent 20,160,002,600, issued January 7, 2016.

E.J. Vrij et al.. 3D High Throughput Screening and profiling of Embryoid Bodies in thermoformed microwell plates.
Lab Chip. 2016 Jan 18.

C. Ziegenhain et al. Comparative analysis of single-cell RNA-sequencing methods.
bioRxiv (2016): 035758.
(2i:CHIR99021 and PD0325901 from Axon Medchem)

B.C.Heng et al. An overview of protocols for the neural induction of dental and oral stem cells in vitro.
Tissue Eng Part B Rev. 2016 Jan 12.
(2i:CHIR99021 and PD0325901 from Axon Medchem)

2015  (53 citations)
J Chal et al. Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy.
Nature Biotechnology 33, 962–969 (2015)

I.J. Huijbers et al.Using the GEMM-ESC strategy to study gene function in mouse models.
Nat Protoc. 2015 Nov;10(11):1755-85.
(2i: CHIR99021 and PD0325901 from Axon Medchem)

M.J. Birket et al. Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells.
Nat Biotechnol. 2015 Sep;33(9):970-9.

H. Kawano et al. Aberrant differentiation of Tsc2-deficient teratomas associated with activation of the mTORC1-TFE3 pathway.
Oncol Rep. 2015 Nov;34(5):2251-8.
(2i from Axon Medchem: CHIR99021 and PD0325901)

A. Kirkeby et al. Generating regionalized neuronal cells from pluripotency, a step-by-step protocol.
C. Parish et al (Ed.) Developing stem cell-based therapies for neural repair.  Frontiers Media 2015, ISBN 2889194027, 9782889194025
(Y27632 and CHIR99021 from Axon Medchem)

H. Iseki et al. Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells.
Stem Cells. 2015 Nov 2.
(2i: CHIR99021 and PD0325901 from Axon Medchm)

S. Haraguchi et al. Chick embryos can form teratomas from microinjected mouse embryonic stem cells.
Dev Growth Differ. 2015 Dec 22.

C.W. van den Berg et al. Differentiation of human pluripotent stem cells to cardiomyocytes under defined conditions.
Methods Mol Biol. 2016;1353:163-80.

M. Ehrlich et al. Distinct neurodegenerative changes in an induced pluripotent stem cell model of frontotemporal dementia linked to mutant tau protein.
Stem Cell Reports. 2015 Jul 14;5(1):83-96.

G. Duggal et al. Alternative routes to induce naïve pluripotency in human embryonic stem cells.
Stem Cells. 2015 Sep;33(9):2686-98.

A. Shahraz et al. Anti-inflammatory activity of low molecular weight polysialic acid on human macrophages.
Sci Rep. 2015 Nov 19;5:16800.
(CHIR99021, SB431542 and Compound E (DBZ) from Axon Medchem)

T. Palm et al. Rapid and robust generation of long-term self-renewing human neural stem cells with the ability to generate mature astroglia.
Sci Rep. 2015 Nov 6;5:16321.

L. Braunschweig et al. Oxygen regulates proliferation of neural stem cells through Wnt/β-catenin signalling.
Mol Cell Neurosci. 2015 Jul;67:84-92.

M.V. Krivega et al. Cyclin E1 plays a key role in balancing between totipotency and differentiation in human embryonic cells.
Mol Hum Reprod. 2015 Dec;21(12):942-56

B. Watmuff et al. Human pluripotent stem cell derived midbrain PITX3eGFP/w neurons: a versatile tool for pharmacological screening and neurodegenerative modeling.
Front Cell Neurosci. 2015 Mar 31;9:104.

S. Meyer et al. Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells.
J Vis Exp. 2015 Jul 29;(101):e52831.

Y. Tabata et al. Multiparametric Phenotypic Screening System for Profiling Bioactive Compounds Using Human Fetal Hippocampal Neural Stem/Progenitor Cells.
J Biomol Screen. 2015 Oct;20(9):1074-83.

Z.E. Madeja et al. WNT/β-Catenin Signaling Affects Cell Lineage and Pluripotency-Specific Gene Expression in Bovine Blastocysts: Prospects for Bovine Embryonic Stem Cell Derivation.
Stem Cells Dev. 2015 Oct 15;24(20):2437-54.

T. Miura et al. Generation of primitive neural stem cells from human fibroblasts using a defined set of factors.
Biol Open. 2015 Oct 21;4(11):1595-607.

J. Rao et al. Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ESCs.
Cell Stem Cell. 2015 Dec 29. pii: S1934-5909(15)00517-2.

J. Chen et al. Evolutionary analysis across mammals reveals distinct classes of long noncoding RNAs.
bioRxiv, 2015 p.031385.

H.D. Devalla et al. Atrial‐like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial‐selective pharmacology.
EMBO Mol Med. 2015 Feb 19;7(4):394-410.

B. Mühl et al. SPREDs (Sprouty Related Proteins with EVH1 Domain) promote self‐renewal and inhibit mesodermal differentiation in murine embryonic stem cells.
Dev Dyn. 2015 Apr;244(4):591-606.

B. Roese-Koerner. 2015. MicroRNAs in neural stem cell proliferation and differentiation
Doctoral dissertation, Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Diss., 2015.
(CHIR99021 and LDN193189 from Axon Medchem)

M. Zhang et al. Universal Cardiac Induction of Human Pluripotent Stem Cells in Two and Three‐Dimensional Formats: Implications for In Vitro Maturation.
Stem Cells. 2015 May;33(5):1456-69.

M. Hosoya et al. Method of producing pancreatic hormone-producing cells.
U.S. Patent 9157069 (B2)

A. Kamiya et al. MEK-ERK Activity Regulates the Proliferative Activity of Fetal Hepatoblasts Through Accumulation of p16/19cdkn2a.
Stem Cells Dev. 2015 Nov 1;24(21):2525-35.
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Application Of Small Molecules Favoring Naïve Pluripotency during Human Embryonic Stem Cell Derivation.
Van der Jeught M, Taelman J, Duggal G, Ghimire S, Lierman S, Chuva de Sousa Lopes SM., Deforce D, Deroo T, De Sutter P, Heindryckx B. 
Cell. Reprogram. 2015, 17(3): 170-180. doi:10.1089/cell.2014.0085.

ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.
D’Uva, G., Aharonov, A., Lauriola, M., Kain, D., Yahalom-Ronen, Y., Carvalho, S., ... & Tzahor, E. (2015).
Nature Cell Biology 2015, 17, 627–638. doi:10.1038/ncb3149

In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.
Bartfeld, S., Bayram, T., van de Wetering, M., Huch, M., Begthel, H., Kujala, P., ... & Clevers, H. (2015).
Gastroenterology, 148(1), 126-136.

DNA lesion identity drives choice of damage tolerance pathway in murine cell chromosomes.
Cohen, I. S., Bar, C., Paz-Elizur, T., Ainbinder, E., Leopold, K., de Wind, N., ... & Livneh, Z.
Nucleic acids research, 2015, 43(3), 1637-1645.
*2i: CHIR99021 and PD0325901 from Axon Medchem

piggyBac Transposon-Based Insertional Mutagenesis in Mouse Haploid Embryonic Stem Cells.
Pettitt, S. J., Tan, E. P., & Yusa, K. (2015).
Chromosomal Mutagenesis, Methods in Meolecular Biology. 2015, Vol. 1239, pp. 15-28. Springer New York.
*2i: CHIR99021 and PD0325901 from Axon Medchem

Functional maturation of human pluripotent stem cell derived cardiomyocytes in vitro–Correlation between contraction force and electrophysiology.
Ribeiro, M. C., Tertoolen, L. G., Guadix, J. A., Bellin, M., Kosmidis, G., D'Aniello, C., ... & Passier, R. (2015).
Biomaterials. 2015 May;51:138-50. doi: 10.1016/j.biomaterials.2015.01.067. Epub 2015 Feb 18. 

Cell aggregation optimizes the differentiation of human ESCs and iPSCs into pancreatic bud-like progenitor cells.
Toyoda, T., Mae, S. I., Tanaka, H., Kondo, Y., Funato, M., Hosokawa, Y., ... & Osafune, K. (2015).
Stem cell research, 2015, 14(2), 185-197.

Generation of Rat Induced Pluripotent Stem Cells Using a Plasmid Vector and Possible Application of a Keratan Sulfate Glycan Recognizing Antibody in Discriminating Teratoma Formation Phenotypes.
Makanga, J. O., Kobayashi, M., Ikeda, H., Christianto, A., Toyoda, H., Yamada, M., ... & Inazu, T. (2015).
Biological and Pharmaceutical Bulletin, 38(1), 127-133. 

A modular open platform for systematic functional studies under physiological conditions.
Mulholland, C. B., Smets, M., Schmidtmann, E., Leidescher, S., Markaki, Y., Hofweber, M., ... & Bultmann, S. (2015).
Nucleic Acids Res. 2015 May 24. pii: gkv550. [Epub ahead of print]
*2i: CHIR99021 and PD0325901 from Axon Medchem

Signalling Through Retinoic Acid Receptors is Required for Reprogramming of Both Mouse Embryonic Fibroblast Cells and Epiblast Stem Cells to Induced Pluripotent Stem Cells.
Yang, J., Wang, W., Ooi, J., Campos, L. S., Lu, L., & Liu, P.
STEM CELLS, 2015, 33(5), 1390-1404.
*2i: CHIR99021 and PD0325901 from Axon Medchem

Dual Reporter MESP1mCherry/w‐NKX2‐5eGFP/w hESCs Enable Studying Early Human Cardiac Differentiation.
Den Hartogh, S. C., Schreurs, C., Monshouwer‐Kloots, J. J., Davis, R. P., Elliott, D. A., Mummery, C. L., & Passier, R. (2015).
Stem Cells. 2015 Jan;33(1):56-67. doi: 10.1002/stem.1842. 

Establishment of Tsc2‑deficient rat embryonic stem cells.
Ito, Y., Kawano, H., Kanai, F., Nakamura, E., Tada, N., Takai, S., ... & Hino, O.
International journal of oncology, 2015, 46(5), 1944-1952.
*2i: CHIR99021 and PD0325901 from Axon Medchem

Establishment and Use of Mouse Haploid ES Cells.
Leeb, M., Perry, A. C., & Wutz, A.
Current Protocols in Mouse Biology, 2015, 155-185.
*2i: CHIR99021 and PD0325901 from Axon Medchem

Functional Compensation Between Myc and PI3K Signaling Supports Self‐Renewal of Embryonic Stem Cells.
Hishida, T., Nakachi, Y., Mizuno, Y., Katano, M., Okazaki, Y., Ema, M., ... & Okuda, A.
Stem Cells, 2015, 33(3), 713-725.
Read more: http://onlinelibrary.wiley.com/doi/10.1002/stem.1893/full
*2i: CHIR99021 and PD0325901 from Axon Medchem

Scalable Electrophysiological Investigation of iPS Cell-Derived Cardiomyocytes Obtained by a Lentiviral Purification Strategy.
Friedrichs, S., Malan, D., Voss, Y., & Sasse, P. (2015).
Journal of Clinical Medicine, 4(1), 102-123.
*CHIR99021 and PD184352 from Axon Medchem 

Interspecific in vitro assay for the chimera-forming ability of human pluripotent stem cells.
Masaki, H., Kato-Itoh, M., Umino, A., Sato, H., Hamanaka, S., Kobayashi, T., ... & Nakauchi, H. (2015).
Development. 2015 May 28. pii: dev.124016. [Epub ahead of print] 

Embryonic stem cell differentiation requires full length Chd1.
Piatti, P., Lim, C. Y., Nat, R., Villunger, A., Geley, S., Shue, Y. T., ... & Lusser, A.
Sci Rep. 2015 Jan 26;5:8007. doi: 10.1038/srep08007.
*2i: CHIR99021 and PD0325901 from Axon Medchem

Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model.
Rahman SH, Kuehle J, Reimann C, Mlambo T, Alzubi J, Maeder ML, et al.
PLoS Genet 11(5): e1005239. doi:10.1371/journal.pgen.1005239
*3i: SB431542, CHIR99021 and PD0325901 from Axon Medchem 

Funktionelle Analyse der Histon-Demethylase UTX in hämatopoetisch differenzierenden murinen ES-Zellen.
Kampka, J. (2015).
Doctoral dissertation of Julius-Maximilians-Universität Würzburg.
*2i: CHIR99021 and PD0325901 from Axon Medchem

Universal Cardiac Induction of Human Pluripotent Stem Cells in Two and Three‐Dimensional Formats: Implications for In Vitro Maturation.
Zhang, M., Schulte, J. S., Heinick, A., Piccini, I., Rao, J., Quaranta, R., ... & Greber, B. (2015).
Stem Cells. 2015 May;33(5):1456-69. doi: 10.1002/stem.1964. 

Method for manufacturing pancreatic-hormone-producing cells.
Hosoya, M., Kunisada, Y., Shoji, M., & Yamazoe, N. (2015).
U.S. Patent No. 8932853.
*CHIR98014, CHIR99021, TDZD-8, SB216763, BIO, TWS-119, and SB415286 were purchased from Axon Medchem

A Protocol for Lentiviral Transduction and Downstream Analysis of Intestinal Organoids.
de Jeude, JFVL., Vermeulen, JL, Montenegro-Miranda, PS, Van den Brink, GR, & Heijmans, J.
J. Vis. Exp. (JoVE) 2015, 98, e52531-e52531. doi:10.3791/5253 

Successful Reprogramming of Epiblast Stem Cells by Blocking Nuclear Localization of β-Catenin.
Murayama, H., Masaki, H., Sato, H., Hayama, T., Yamaguchi, T., & Nakauchi, H. (2015).
Stem cell reports 4.1 (2015): 103-113.
*2i: CHIR99021 and PD0325901 from Axon Medchem

Gene activation-associated long noncoding RNAs function in mouse preimplantation development.
Hamazaki, N., Uesaka, M., Nakashima, K., Agata, K., & Imamura, T. 
Development. 2015 Mar 1;142(5):910-20. doi: 10.1242/dev.116996. Epub 2015 Jan 29.

Endogenous WNT Signals Mediate BMP-Induced and Spontaneous Differentiation of Epiblast Stem Cells and Human Embryonic Stem Cells.
Kurek, D., Neagu, A., Tastemel, M., Tüysüz, N., Lehmann, J., van de Werken, H. J., ... & ten Berge, D.
Stem Cell Reports. 2015, 4, 114-118.

2014 (38 citations)
YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response.
L Azzolin, T Panciera, S Soligo, E Enzo, S Bicciato, S Dupont, S Bresolin, C Frasson, G Basso, V Guzzardo, A Fassina, M Cordenonsi, S Piccolo.
Cell, 2014, 158 (1), 157-170. doi:10.1016/j.cell.2014.06.013
*CHIR99021 from Axon Medchem has been used in this study.

Differentiation of Human Pluripotent Stem Cells to Cardiomyocytes Under Defined Conditions.
van den Berg, C. W., Elliott, D. A., Braam, S. R., Mummery, C. L., & Davis, R. P. (2014). 
Methods in Molecular Biology, 10, 7651_2014_178.

Molecular and Functional Analyses of Motor Neurons Generated from Human Cord-Blood-Derived Induced Pluripotent Stem Cells. 
Naujock, M., Stanslowsky, N., Reinhardt, P., Sterneckert, J., Haase, A., Martin, U., ... & Petri, S. (2014). 
Stem cells and development, 23(24), 3011-3020.

Epigenetic Characterization of the FMR1 Promoter in Induced Pluripotent Stem Cells from Human Fibroblasts Carrying an Unmethylated Full Mutation.
de Esch, C. E., Ghazvini, M., Loos, F., Schelling-Kazaryan, N., Widagdo, W., Munshi, S. T., ... & Willemsen.
Stem Cell Reports. 2014, 3, 548–555.
* PD0325901 (1μM, ERK1/2i, Axon 1408); CHIR99021 (3μM, GSK3i, Axon 1386); SB203580 (10 μM, p38i, Axon 1363) Y-27632 (5μM, Axon 1683) from Axon Medchem.

A screen for transcription factor targets of Glycogen Synthase Kinase-3 highlights an inverse correlation of NFκB and Androgen Receptor Signaling in Prostate Cancer.
Campa, V. M., Baltziskueta, E., Bengoa-Vergniory, N., Gorroño-Etxebarria, I., Wesołowski, R., Waxman, J., & Kypta, R. M.
Oncotarget. 2014 Sep; 5(18): 8173–8187.

Origin-Dependent Neural Cell Identities in Differentiated Human iPSCs In Vitro and after Transplantation into the Mouse Brain. 
Hargus, G., Ehrlich, M., Araúzo-Bravo, M. J., Hemmer, K., Hallmann, A. L., Reinhardt, P., ... & Zaehres, H. (2014). 
Cell reports, 8(6), 1697-1703.

Erk Signaling Suppresses Embryonic Stem Cell SelfRenewal to Specify Endoderm.
Hamilton, W. B., & Brickman, J. M. 
Cell report, 2014, 9(6), 2056–2070.
*2i: CHIR99021 and PD0325901 from Axon Medchem 

Isolated naive pluripotent stem cells and methods of generating same.
Hanna, Yaqub, Noa Novershtern, and Yoach Rais. (2014).
US Patent Application 14/259,997. US 20140315301 A1
*2i CHIR99021 and PD0325901 and 20 other compounds from Axon Medchem

The role of chromatin organization and structure in neuronal differentiation.
Weng, M. K. 2014
PhD Thesis

Targeted organ generation using Mixl1-inducible mouse pluripotent stem cells in blastocyst complementation. 
Kobayashi, T., Kato-Itoh, M., & Nakauchi, H. (2014). 
Stem cells and development, 24(2), 182-189.
*2i used in this study and CHIR99021 from Axon Medchem

Direct Neural Conversion from Human Fibroblasts Using Self-Regulating and Nonintegrating Viral Vectors. 
Lau, S., Ottosson, D. R., Jakobsson, J., & Parmar, M. 
Cell reports, 2014, 9(5), 1673-1680.
*CHIR99021 and LDN193189 from Axon Medchem

Gene Targeting Study Reveals Unexpected Expression of Brain expressed X-linked 2 in Endocrine and Tissue Stem/progenitor Cells in Mice.
K Ito, S Yamazaki, R Yamamoto, Y Tajima, A Yanagida, T Kobayashi, M Kato-Itoh, S Kakuta, Y Iwakura, H Nakauchi and A Kamiya*.
J Biol Chem. 2014 Oct 24;289(43):29892-911. doi: 10.1074/jbc.M114.580084. Epub 2014 Aug 20.
*2i: CHIR99021 (Axon 1386) and PD0325901 (Axon 1408) were procured from Axon Medchem. 

The Generation and Maintenance of Rat Induced Pluripotent Stem Cells.
T Yamaguchi, S Hamanaka, H Nakauchi.
Stem Cells and Tissue Repair. Methods in Molecular Biology. 2014, 1210, 143-150. Date: 06 Aug 2014
*2i used and CHIR99021 from Axon Medchem

Dual reporter MESP1mCherry/w-NKX2-5eGFP/w hESCs enable studying early human cardiac differentiation.
SC Den Hartogh, C Schreurs, JJ Monshouwer-Kloots, RP Davis1, DA Elliott, C Mummery and R Passier.
Stem Cells. 2015 Jan;33(1):56-67. doi: 10.1002/stem.1842.

CULTURE MEDIA FOR STEM CELLS.
JC Clevers, T Sato, M Huch Ortega, W Richard.
US Patent Application 20140243227.
*2i: CHIR99021 (Axon 1386) and PD0325901 (Axon 1408) from Axon Medchem 

Identifying Nuclear Protein–Protein Interactions Using GFP Affinity Purification and SILAC-Based Quantitative Mass Spectrometry.
HI Baymaz, CG Spruijt, M Vermeulen.
Methods in Molecular Biology 2014, 1188, 207-226.
2i inhibitors (Axon Medchem, CHIR99021 and PD0325901 

Generation of Alveolar Epithelial Spheroids via Isolated Progenitor Cells from Human Pluripotent Stem Cells.
S Gotoh, I Ito, T Nagasaki, Y Yamamoto, S Konishi, Y Korogi, H Matsumoto, S Muro, T Hirai, M Funato, SI Mae, T Toyoda, A Sato-Otsubo, S Ogawa, K Osafune, M Mishima.
Stem Cell Reports, 2014, in press. DOI: 10.1016/j.stemcr.2014.07.005

Serum supplemented culture medium masks hypertrophic phenotypes in human pluripotent stem cell derived cardiomyocytes.
C Dambrot, SR Braam, LGJ Tertoolen, M Birket, DE Atsma and CL Mummery.
J. Cell. Mol. Med., 2014, online 1 Jul 2014. DOI: 10.1111/jcmm.12356

Reprogramming activity of NANOGP8, a NANOG family member widely expressed in cancer.
AR Palla, D Piazzolla, M Abad, H Li, O Dominguez, HB Schonthaler, EF Wagner and M Serrano.
Oncogene 2014, 33, 2513–2519.
2i: CHIR99021 (Axon 1386) and PD0325901 (Axon 1408) from Axon Medchem 

Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia.
D Piazzolla, AR Palla, C Pantoja, M Cañamero… & M Serrano*.
Nature Communications, 2014, 5 (4226), in press. doi:10.1038/ncomms5226
*2i: CHIR99021 (Axon 1386) and PD0325901 (Axon 1408) are procured from Axon Medchem.

TET-mediated oxidation of methylcytosine causes TDG or NEIL glycosylase dependent gene reactivation.
U Müller, C Bauer, M Siegl, A Rottach, H Leonhardt*
Nucl. Acids Res. (2014) online Jun 19, 2014. doi: 10.1093/nar/gku552
2i: PD0325901 (Axon 1408) and CHIR99021 (Axon 1386) 

Development of FGF2-dependent pluripotent stem cells showing naive state characteristics from murine preimplantation inner cell mass.
M Ozawa, E Kawakami, R Sakamoto, T Shibasaki, A Gotoa, N Yoshida.
Stem Cell Res. 2014, 13 (1), 75–87.  DOI: 10.1016/j.scr.2014.04.012
Read more: http://www.sciencedirect.com/science/article/pii/S1873506114000488 

Effect of Leukemia Inhibitory Factor and Forskolin on Establishment of Rat Embryonic Stem Cell Lines.
M Hirabayashi, C TAMURA, M SANBO, H HARA, S Hochi.
J. Reprod. Devel. 2014, 60 (1), 78-82.  doi:  10.1262/jrd.2013-109

Dynamics and evolution of β-catenin-dependent Wnt signaling revealed through massively parallel clonogenic screening.
PK Shah, MP Walker, CE Sims, MB Major, NL Allbritton*
Integr. Biol.,2014, 6, 673-684.  DOI: 10.1039/C4IB00050A