Proteases (Serine)

The large family of serine proteases (almost one-third of all proteases; EC 3.4.21.-) is characterized by its general mechanism of action to cleave peptide bonds in proteins, in which serine serves as the nucleophilic amino acid at the (enzyme's) active site. The members of this family  can be divided roughly into four sub-groups based on their structure, being chymotrypsin-like (trypsin-like), subtilisin-like, carboxypeptidase Y-like, and Clp-like[1].


[1] L. Hedstrom. Serine Protease Mechanism and Specificity. Chem. Rev. 2002, 102, 4501-4524.

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Axon ID Name Description From price
1754 Apixaban Factor Xa inhibitor €125.00
2093 Daclatasvir dihydrochloride Hepatitis C virus (HCV) NS5A protein inhibitor €85.00
1669 Danoprevir HCV NS3/4A serine protease inhibitor €115.00
2364 GW 311616A Potent, selective and orally active human neutrophil elastase (HNE) inhibitor €135.00
1536 Odiparcil Thrombin inhibitor (via Heparin CoFII) €125.00
1269 SSR 69071 HLE inhibitor €145.00
1769 T 1776Na Inhibitor of plasminogen activator inhibitor-1 €95.00
1383 Tiplaxtinin Plasminogen activator inhibitor-1 (PAI-1) inhibitor €75.00
2344 TM 5275 Selective and orally active inhibitor of PAI-1 €105.00

9 Item(s)

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