Proteases (Serine)

The large family of serine proteases (almost one-third of all proteases; EC 3.4.21.-) is characterized by its general mechanism of action to cleave peptide bonds in proteins, in which serine serves as the nucleophilic amino acid at the (enzyme's) active site. The members of this family  can be divided roughly into four sub-groups based on their structure, being chymotrypsin-like (trypsin-like), subtilisin-like, carboxypeptidase Y-like, and Clp-like[1].

[1] L. Hedstrom. Serine Protease Mechanism and Specificity. Chem. Rev. 2002, 102, 4501-4524.

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Axon ID Name Description From price
3590 ACT001 PAI-1 inhibitor €210.00
1754 Apixaban Factor Xa inhibitor €95.00
2822 BAY-678 Potent, selective and orally active human neutrophil elastase (HNE) inhibitor €105.00
3568 Col003 Potent, competitive collagen-Hsp47 interaction inhibitor €110.00
3117 Dabigatran etexilate Prodrug of Dabigatran; Thrombin inhibitor €70.00
2093 Daclatasvir dihydrochloride Hepatitis C virus (HCV) NS5A protein inhibitor €70.00
1669 Danoprevir HCV NS3/4A serine protease inhibitor €90.00
3116 Edoxaban tosylate Potent, selective and orally active factor Xa inhibitor €100.00
2364 GW 311616A Potent, selective and orally active human neutrophil elastase (HNE) inhibitor €120.00
3294 HSP47 inhibitor III Inhibitor of the collagen-specific chaperone HSP47 €120.00
3300 Ledipasvir Potent and orally available NS5A inhibitor €95.00
1536 Odiparcil Thrombin inhibitor (via Heparin CoFII) €140.00
3581 ONC212 TRAIL inducer; Selective GPR132 agonist €110.00
3710 PAZ-417 Potent, orally active and CNS-penetrant PAI-1 inhibitor €130.00
3875 PCI-27483 PCI-27483 is a potent and selective small-molecule inhibitor of activated factor VII (factor VIIa) Inquire
3175 Rivaroxaban Highly potent, selective and oral direct FXa inhibitor €70.00
2838 SK-216 Specific inhibitor of PAI-1 €105.00
1269 SSR 69071 HLE inhibitor €145.00
1769 T 1776Na Inhibitor of plasminogen activator inhibitor-1 €80.00
1383 Tiplaxtinin Plasminogen activator inhibitor-1 (PAI-1) inhibitor €70.00
2344 TM 5275 Selective and orally active inhibitor of PAI-1 €105.00
2734 TM 5441 Orally active inhibitor of PAI-1 €105.00
3618 uPA inhibitor BC-11 hydrobromide Highly specific urokinase-plasminogen activator (uPa) inhibitor €115.00
3173 Velpatasvir Hepatitis C virus NS5A inhibitor €50.00
2911 Y 29794 tosylate Orally active, brain penetrant, potent and specific prolyl endopeptidase (PPCE) inhibitor €125.00

25 Item(s)

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