Proteases (Serine)
The large family of serine proteases (almost one-third of all proteases; EC 3.4.21.-) is characterized by its general mechanism of action to cleave peptide bonds in proteins, in which serine serves as the nucleophilic amino acid at the (enzyme's) active site. The members of this family can be divided roughly into four sub-groups based on their structure, being chymotrypsin-like (trypsin-like), subtilisin-like, carboxypeptidase Y-like, and Clp-like[1].
[1] L. Hedstrom. Serine Protease Mechanism and Specificity. Chem. Rev. 2002, 102, 4501-4524.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 3590 | ACT001 | PAI-1 inhibitor | €210.00 | |
| 1754 | Apixaban | Factor Xa inhibitor | €95.00 | |
| 2822 | BAY-678 | Potent, selective and orally active human neutrophil elastase (HNE) inhibitor | €105.00 | |
| 3568 | Col003 | Potent, competitive collagen-Hsp47 interaction inhibitor | €110.00 | |
| 3117 | Dabigatran etexilate | Prodrug of Dabigatran; Thrombin inhibitor | €70.00 | |
| 2093 | Daclatasvir dihydrochloride | Hepatitis C virus (HCV) NS5A protein inhibitor | €70.00 | |
| 1669 | Danoprevir | HCV NS3/4A serine protease inhibitor | €90.00 | |
| 3116 | Edoxaban tosylate | Potent, selective and orally active factor Xa inhibitor | €100.00 | |
| 2364 | GW 311616A | Potent, selective and orally active human neutrophil elastase (HNE) inhibitor | €120.00 | |
| 3294 | HSP47 inhibitor III | Inhibitor of the collagen-specific chaperone HSP47 | €120.00 | |
| 3300 | Ledipasvir | Potent and orally available NS5A inhibitor | €95.00 | |
| 1536 | Odiparcil | Thrombin inhibitor (via Heparin CoFII) | €140.00 | |
| 3581 | ONC212 | TRAIL inducer; Selective GPR132 agonist | €110.00 | |
| 3710 | PAZ-417 | Potent, orally active and CNS-penetrant PAI-1 inhibitor | Recently added | €130.00 |
| 3175 | Rivaroxaban | Highly potent, selective and oral direct FXa inhibitor | €70.00 | |
| 2838 | SK-216 | Specific inhibitor of PAI-1 | €105.00 | |
| 1269 | SSR 69071 | HLE inhibitor | €145.00 | |
| 1769 | T 1776Na | Inhibitor of plasminogen activator inhibitor-1 | €80.00 | |
| 1383 | Tiplaxtinin | Plasminogen activator inhibitor-1 (PAI-1) inhibitor | €70.00 | |
| 2344 | TM 5275 | Selective and orally active inhibitor of PAI-1 | €105.00 | |
| 2734 | TM 5441 | Orally active inhibitor of PAI-1 | €95.00 | |
| 3618 | uPA inhibitor BC-11 hydrobromide | Highly specific urokinase-plasminogen activator (uPa) inhibitor | €115.00 | |
| 3173 | Velpatasvir | Hepatitis C virus NS5A inhibitor | €50.00 | |
| 2911 | Y 29794 tosylate | Orally active, brain penetrant, potent and specific prolyl endopeptidase (PPCE) inhibitor | €125.00 | |