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SSR 69071

Axon 1269
CAS:  344930-95-6
Purity:  99%
  • Soluble in DMSO and EtOH
  • MF:  C27H32N4O7S
  • MW:  556.63

Description

SSR 69071 is a highly potent and selective human leukocyte elastase (HLE)/neutrophil elastase inhibitor with a reported Ki value of 0.02 nM.

Neutrophil elastase is a serine protease involved in extracellular matrix degradation, inflammatory tissue injury and pulmonary disease mechanisms. SSR 69071 is useful for studying elastase-driven proteolysis and anti-inflammatory protease inhibition.

Key Features

  • Highly potent and selective human leukocyte elastase inhibitor
  • Reported Ki: 0.02 nM
  • Targets neutrophil elastase-mediated proteolysis
  • Relevant to inflammatory tissue injury and pulmonary pathway research

Applications

  • Neutrophil elastase enzyme assays
  • Serine protease inhibitor profiling
  • Inflammation and tissue damage models
  • Pulmonary disease mechanism research

More Information

Parent CAS No. 344930-95-6
Chemical Name 2-(4-Isopropyl-6-methoxy-1,1,3-trioxo-1,3-dihydro-1lambda*6*-benzo[d]isothiazol-2-ylmethoxy)-9-(2-piperidin-1-yl-ethoxy)-pyrido[1,2-a]pyrimidin-4-one
SMILES S1(=O)(=O)C2C=C(OC)C=C(C(C)C)C=2C(=O)N1COC1=CC(N2C=CC=C(OCCN3CCCCC3)C2=N1)=O
MFCD MFCD09027353
InChi InChI=1S/C27H32N4O7S/c1-18(2)20-14-19(36-3)15-22-25(20)27(33)31(39(22,34)35)17-38-23-16-24(32)30-11-7-8-21(26(30)28-23)37-13-12-29-9-5-4-6-10-29/h7-8,11,14-16,18H,4-6,9-10,12-13,17H2,1-3H3
InChiKey DRZXDZYWZSKFDL-UHFFFAOYSA-N
CID 9872438
Short Description HLE inhibitor

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