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Micheliolide
- MCL
Axon 3607
CAS:
68370-47-8
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C15H20O3
- MW: 248.32
Description
Micheliolide, a guaianolide sesquiterpene lactone, is an inhibitor of NF-κB pathway activation leading to downregulation of major inflammatory mediator expression such as TNFα and IL-1β. Moreover, MCL has been reported as inhibitor of acute leukemic cells. The prodrug of MCL, ACT001 is also available as Axon 3590.
More Information
| Parent CAS No. | 68370-47-8 |
|---|---|
| Chemical Name | (3aS,9R,9aS,9bS,Z)-9-Hydroxy-6,9-dimethyl-3-methylene-3,3a,4,5,7,8,9,9a-octahydroazuleno[4,5-b]furan-2(9bH)-one |
| SMILES | [C@@]12([H])[C@H]3OC(=O)C(=C)[C@@H]3CCC(C)=C1CC[C@]2(O)C |&1:0,2,8,16,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C15H20O3/c1-8-4-5-11-9(2)14(16)18-13(11)12-10(8)6-7-15(12,3)17/h11-13,17H,2,4-7H2,1,3H3/t11-,12-,13-,15+/m0/s1 |
| InChiKey | RDJAFOWISVMOJY-PWNZVWSESA-N |
| CID | 442279 |
| Short Description | NF-κB inhibitor |
References
- E Viennois et al. Micheliolide, a new sesquiterpene lactone that inhibits intestinal inflammation and colitis-associated cancer. Lab Invest. 2014 Sep;94(9):950-65.
- Q Zhang et al. Guaianolide sesquiterpene lactones, a source to discover agents that selectively inhibit acute myelogenous leukemia stem and progenitor cells. J Med Chem. 2012 Oct 25;55(20):8757-69.
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