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NF-κB Activation Inhibitor IV
- NFκBAI4 - FME
Axon 3387
CAS:
139141-12-1
Purity:
99%
- Soluble in DMSO
- MF: C15H13FO
- MW: 228.26
Description
NF-κB Activation Inhibitor IV is a resveratrol analogue which potently inhibits the TNFα-induced activation of NF-κB (IC50 value of 0.15 μM) and is devoid of antioxidant activity.
More Information
| Parent CAS No. | 139141-12-1 |
|---|---|
| Chemical Name | (E)-1-Fluoro-2-(4-methoxystyryl)benzene |
| SMILES | C1C=C(/C=C/C2C(F)=CC=CC=2)C=CC=1OC |
| MFCD | N.A. |
| InChi | InChI=1S/C15H13FO/c1-17-14-10-7-12(8-11-14)6-9-13-4-2-3-5-15(13)16/h2-11H,1H3/b9-6+ |
| InChiKey | ILVFNAZMSMNXJG-RMKNXTFCSA-N |
| CID | 15113698 |
| Short Description | NF-κB inhibitor |
References
- JJ Heynekamp et al. Substituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription factor nuclear factor kappaB. J Med Chem. 2006 Nov 30;49(24):7182-9.
- A Braeuning et al. The nuclear factor κB inhibitor (E)-2-fluoro-4'-methoxystilbene inhibits firefly luciferase. Biosci Rep. 2012 Dec;32(6):531-7.
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