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Sulfasalazine
- SSZ
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C18H14N4O5S
- MW: 398.39
Description
Sulfasalazine is an anti-inflammatory disease-modifying compound reported to inhibit NF-κB activation through IKKα/IKKβ blockade and to modulate additional inflammatory stress pathways including cystine/glutamate exchange in some models.
Sulfasalazine is used in inflammatory bowel disease and rheumatoid arthritis research and has also been applied in studies of hepatic stellate cell apoptosis, fibrosis resolution and inflammatory transcriptional control.
Key Features
- Anti-inflammatory NF-κB pathway modulator
- Reported inhibition of IKKα and IKKβ activity
- Used to study hepatic stellate cell apoptosis and fibrosis responses
- Relevant to rheumatoid arthritis and IBD pharmacology
Applications
- NF-κB signaling studies
- Inflammatory bowel disease models
- Rheumatoid arthritis research
- Fibrosis and hepatic stellate cell assays
More Information
| Parent CAS No. | 599-79-1 |
|---|---|
| Chemical Name | 2-hydroxy-5-((4-(N-pyridin-2-ylsulfamoyl)phenyl)diazenyl)benzoic acid |
| extra_info | . |
| SMILES | C(O)(=O)C1=CC(/N=N/C2=CC=C(S(NC3=NC=CC=C3)(=O)=O)C=C2)=CC=C1O |
| MFCD | MFCD00057363 |
| InChi | InChI=1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+ |
| InChiKey | NCEXYHBECQHGNR-QZQOTICOSA-N |
| CID | 5339 |
| Short Description | IKK inhibitor |
References
- F Oakley et al. Inhibition of inhibitor of κB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis. Gastroenterology 2005, 128(1), 108–120.
- C Wahl et al. Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B. J. Clin. Invest. 1998, 101(5), 1163.
- CK Weber et al. Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta. Gastroenterology. 2000, 119(5), 1209-1218.
- S Liptay et al. Molecular mechanisms of sulfasalazine-induced T-cell apoptosis. Br. J. Pharmacol. 2002, 137(5), 608-620.
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