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BAY 11-7082

 - BAY 11-7821
Axon 2132
CAS:  19542-67-7
Purity:  99%
  • Soluble in DMSO
  • MF:  C10H9NO2S
  • MW:  207.25

Description

IKK inhibitor and broad-spectrum inhibitor with anti-inflammatory activity against multiple targets. BAY strongly suppressed the production of nitric oxide, prostaglandin E2, and TNF-α and reduced the translocation of p65, major subunit of nuclear factor-κB, and its upstream signaling events such as phosphorylation of IκBα, IKK, and Akt. In addition, BAY also inhibits the phosphorylation or activation of extracellular signal-related kinase, p38, TANK-binding protein, and JAK-2.

More Information

Parent CAS No. 19542-67-7
Chemical Name (E)-3-(p-tolylsulfonyl)acrylonitrile
SMILES C(#N)/C=C/S(C1=CC=C(C)C=C1)(=O)=O
MFCD MFCD00712162
InChi InChI=1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+
InChiKey DOEWDSDBFRHVAP-KRXBUXKQSA-N
CID 5353431
Short Description IKK inhibitor

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