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CDDO-Me
- Bardoxolone methyl - RTA 402
- Soluble in DMSO
- MF: C32H43NO4
- MW: 505.69
Description
CDDO-Me is an orally available antioxidant inflammation modulator and Nrf2 pathway inducer that also directly blocks IKKβ activity and NF-κB signaling.
CDDO-Me (Bardoxolone methyl) modulates redox-sensitive transcriptional programs and can induce tumor cell apoptosis through disruption of redox balance. It is useful for studying Nrf2 activation, inflammatory signaling and cancer cell stress responses.
Key Features
- Potent inducer of Nrf2 pathway signaling
- Directly blocks IKKβ/NF-κB activity in reported studies
- Induces apoptosis through redox balance disruption
- Orally available triterpenoid pharmacology
Applications
- Nrf2/Keap1 pathway research
- Inflammation and NF-κB signaling studies
- Cancer cell apoptosis and stress assays
- Redox biology and oxidative stress models
More Information
| Parent CAS No. | 218600-53-4 |
|---|---|
| Chemical Name | (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-methyl 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate |
| MFCD | N.A. |
| Short Description | Apoptosis inducer |
References
- R Ahmad et al. Triterpenoid CDDO-Me Blocks the NF-κB Pathway by Direct Inhibition of IKKβ on Cys-179. J. Biol. Chem. 2006, 281, 35764-35769.
- M Konopleva et al. Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia. Blood 2002, 99(1), 326-335.
- R Ahmad et al. Combining the FLT3 inhibitor PKC412 and the triterpenoid CDDO-Me synergistically induces apoptosis in acute myeloid leukemia with the internal tandem duplication mutation. Mol. Cancer Res. 2010, 8(7), 986-993.
- MB Sporn et al. New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress. J. Nat. Prod. 2011, 74(3), 537-545.
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