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CDDO
- Bardoxolone - RTA 401
- Soluble in DMSO
- MF: C31H41NO4
- MW: 491.66
Description
A potent multifunctional anti-tumor agent; CDDO induces apoptosis in vitro in malignant cells through both intrinsic and extrinsic pathways, and it controls cellular differentiation, apoptosis, and growth inhibition by serving as a ligand for the transcription factor PPAR-γ; highly active inhibitor of nitric oxide production in mouse macrophages; it shows antiinflammatory activity against thioglycollate-interferon-gamma-induced mouse peritonitis
* Parent acid of CDDO-Me (Axon 1772)
More Information
| Parent CAS No. | 218600-44-3 |
|---|---|
| Chemical Name | (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylic acid |
| MFCD | MFCD07772296 |
| Short Description | Apoptosis inducer |
References
- T Honda et al. Synthetic oleanane and ursane triterpenoids with modified rings A and C: a series of highly active inhibitors of nitric oxide production in mouse macrophages. J. Med. Chem. 2000, 43(22), 4233-4246.
- S Inoue et al. CDDO induces apoptosis via the intrinsic pathway in lymphoid cells. Leukemia 2004, 18(5), 948-952.
- K Liby et al. The Synthetic Triterpenoids, CDDO and CDDO-Imidazolide, Are Potent Inducers of Heme Oxygenase-1 and Nrf2/ARE Signaling. Cancer Res. 2005, 65(11), 4789-4798.
- SH Bernstein et al. The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives. Blood 2012, 119(14), 3321-3329.
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