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KRP 297
- MK 767
- Soluble in DMSO
- MF: C20H17F3N2O4S
- MW: 438.42
Description
KRP 297 (MK-767) is a dual PPARα and PPARγ agonist with pharmacology relevant to lipid and glucose metabolism.
PPARα regulates fatty acid oxidation, while PPARγ controls adipocyte differentiation and insulin sensitivity. KRP 297 is useful for studying combined nuclear receptor activation in metabolic disease models and transcriptional regulation of energy homeostasis.
Key Features
- Dual agonist of PPARα and PPARγ
- Modulates lipid metabolism and insulin-sensitivity pathways
- Nuclear receptor ligand for metabolic pharmacology
- Useful for comparing PPARα versus PPARγ-driven responses
Applications
- PPAR nuclear receptor assays
- Diabetes and insulin-resistance research
- Lipid metabolism studies
- Adipocyte differentiation models
More Information
| Parent CAS No. | 213252-19-8 |
|---|---|
| Chemical Name | 5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-methoxy-N-(4-trifluoromethyl-benzyl)-benzamide |
| SMILES | C1C(CC2SC(=O)NC2=O)=CC(C(=O)NCC2C=CC(C(F)(F)F)=CC=2)=C(OC)C=1 |
| MFCD | MFCD00953587 |
| InChi | InChI=1S/C20H17F3N2O4S/c1-29-15-7-4-12(9-16-18(27)25-19(28)30-16)8-14(15)17(26)24-10-11-2-5-13(6-3-11)20(21,22)23/h2-8,16H,9-10H2,1H3,(H,24,26)(H,25,27,28) |
| InChiKey | NFFXEUUOMTXWCX-UHFFFAOYSA-N |
| CID | 151183 |
| Short Description | PPARα/γ inhibitor |
References
- AC Calkin et al. MK-767. Kyorin/Banyu/Merck. Curr Opin Investig Drugs. 2003, 4(4), 444-8.
- M Nomura et al. (3-Substituted benzyl)thiazolidine-2,4-diones as structurally new antihyperglycemic agents. Bioorg. Med. Chem. Lett. 1999, 9(4), 533.
- K Murakami et al. A novel insulin sensitizer acts as a coligand for PPAR-alpha and PPAR-gamma: effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats. Diabetes 1998, 47(12), 1841-1847.
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