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GSK 3787
- Soluble in DMSO
- MF: C15H12ClF3N2O3S
- MW: 392.78
Description
GSK 3787 is a selective, irreversible antagonist of peroxisome proliferator-activated receptor δ (PPARδ/PPARβ).
PPARδ regulates lipid metabolism, inflammation, energy expenditure and transcriptional programs linked to metabolic disease and cancer biology. GSK 3787 is useful for blocking PPARδ-dependent transcription and studying nuclear receptor selectivity.
Key Features
- Selective irreversible PPARδ antagonist
- Blocks PPARδ-dependent transcriptional signaling
- Useful for distinguishing PPARδ from PPARα and PPARγ biology
- Relevant to metabolic and inflammatory pathway research
Applications
- PPARδ nuclear receptor assays
- Metabolic transcription research
- Lipid and inflammatory signaling studies
- Nuclear receptor antagonist profiling
More Information
| Parent CAS No. | 188591-46-0 |
|---|---|
| Chemical Name | 4-chloro-N-(2-(5-(trifluoromethyl)pyridin-2-ylsulfonyl)ethyl)benzamide |
| SMILES | S(C1N=CC(C(F)(F)F)=CC=1)(=O)(=O)CCNC(C1C=CC(Cl)=CC=1)=O |
| MFCD | N.A. |
| InChi | InChI=1S/C15H12ClF3N2O3S/c16-12-4-1-10(2-5-12)14(22)20-7-8-25(23,24)13-6-3-11(9-21-13)15(17,18)19/h1-6,9H,7-8H2,(H,20,22) |
| InChiKey | JFUIMTGOQCQTPF-UHFFFAOYSA-N |
| CID | 2800647 |
| Short Description | PPARδ antagonist |
References
- PS Palkar et al. Cellular and Pharmacological Selectivity of the PPARβ/δ Antagonist GSK3787. Mol. Pharmacol. Fast Forward. 2010.06.01.
- BG Shearer et al. Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible PPARdelta antagonist. J. Med. Chem. 2010, 53(4), 1857-61.
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