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MHY 908
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C17H14ClNO3S
- MW: 347.82
Description
MHY 908 is a dual PPARα/PPARγ agonist with additional anti-melanogenic activity through tyrosinase inhibition. It activates nuclear receptor pathways linked to lipid metabolism and insulin sensitization while reducing melanogenesis in pigment-cell models.
PPARα and PPARγ regulate fatty-acid oxidation, adipocyte differentiation, glucose handling and inflammatory gene expression. MHY 908 is useful for connecting metabolic nuclear receptor pharmacology with melanogenesis, oxidative stress and dermatology-oriented cell biology.
Key Features
- Dual PPARα/PPARγ agonist profile
- Inhibits mushroom tyrosinase activity (IC50: 8.19 µM)
- More potent PPAR activation reported than fenofibrate and rosiglitazone in comparative assays
- Reduces melanogenesis-related signaling in pigment-cell models
Applications
- PPAR nuclear receptor pharmacology
- Metabolic disease and insulin-sensitization research
- Melanogenesis and pigmentation studies
- Anti-inflammatory and dermatology-relevant pathway assays
More Information
| Parent CAS No. | 1393371-39-5 |
|---|---|
| Chemical Name | 2-(4-(5-chlorobenzo[d]thiazol-2-yl)phenoxy)-2-methylpropanoic acid |
| SMILES | C(O)(=O)C(OC1=CC=C(C2=NC3=CC(Cl)=CC=C3S2)C=C1)(C)C |
| MFCD | N.A. |
| InChi | InChI=1S/C17H14ClNO3S/c1-17(2,16(20)21)22-12-6-3-10(4-7-12)15-19-13-9-11(18)5-8-14(13)23-15/h3-9H,1-2H3,(H,20,21) |
| InChiKey | HJOJVKDSEPDKSE-UHFFFAOYSA-N |
| CID | 68279301 |
| Short Description | PPARα/γ agonist |
References
- M.H. Park et al. Potent anti-diabetic effects of MHY908, a newly synthesized PPAR α/γ dual agonist in db/db mice. PLoS One. 2013 Nov 14;8(11):e78815.
- M.H. Park et al. Inhibition of melanogenesis by 2-[4-(5-chlorobenzo[d]thiazol-2-yl)phenoxy]-2-methylpropanoic acid (MHY908). Arch Pharm Res. 2014 Dec 14. [Epub ahead of print]
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