Bulk Inquiry
WY 14643
- Soluble in DMSO
- MF: C14H14ClN3O2S
- MW: 323.8
Description
WY 14643 is a selective peroxisome proliferator-activated receptor alpha (PPARα) agonist.
PPARα is a nuclear receptor that regulates fatty acid oxidation, lipid handling, peroxisome proliferation and inflammatory gene expression. WY 14643 is a standard agonist for activating PPARα-dependent transcriptional programs.
Key Features
- Selective PPARα agonist
- Activates nuclear receptor-mediated lipid metabolism pathways
- Useful for fatty acid oxidation and peroxisome proliferation studies
- Reference tool for PPARα transcriptional activation
Applications
- PPAR reporter assays
- Lipid metabolism and fatty acid oxidation studies
- Nuclear receptor pharmacology
- Inflammation and metabolic pathway research
More Information
| Parent CAS No. | 50892-23-4 |
|---|---|
| Chemical Name | [4-Chloro-6-(2,3-dimethyl-phenylamino)-pyrimidin-2-ylsulfanyl]-acetic acid |
| SMILES | C1=C(Cl)N=C(SCC(O)=O)N=C1NC1C(C)=C(C)C=CC=1 |
| MFCD | MFCD00191335 |
| InChi | InChI=1S/C14H14ClN3O2S/c1-8-4-3-5-10(9(8)2)16-12-6-11(15)17-14(18-12)21-7-13(19)20/h3-6H,7H2,1-2H3,(H,19,20)(H,16,17,18) |
| InChiKey | SZRPDCCEHVWOJX-UHFFFAOYSA-N |
| CID | 5694 |
| Short Description | PPARα agonist |
References
- Forman et al. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and d. Proc. Natl. Acad. Sci. USA 1997, 94, 4312.
- Bishop-Bailey. Peroxisome proliferator-activated receptors in the cardiovascular system. Br. J. Pharmacol. 2000, 129, 823.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1237 | GW 7647 |
From $104.50 |
| 1567 | KRP 297 |
From $121.00 |
| 1628 | GSK 3787 |
From $99.00 |
| 1950 | CDDO |
From $88.00 |
| 2019 | INT131 |
From $99.00 |
| 2114 | CP 775146 |
From $121.00 |
| 2260 | LDN 212320 |
From $99.00 |
| 2262 | GW 9662 |
From $66.00 |
| 2275 | AdipoRon |
From $88.00 |
| 2379 | ZLN 005 |
From $55.00 |
| 2402 | MHY 908 |
From $104.50 |
| 2427 | L-TBOA ammonia salt |
From $148.50 |
| 2443 | Rosiglitazone |
From $104.50 |
| 2533 | Hydroxypioglitazone |
From $198.00 |
| 2640 | TFB-TBOA |
From $198.00 |
| 2686 | FH535 |
From $82.50 |
| 2706 | FH535 sodium salt |
From $88.00 |
| 2727 | Elafibranor |
From $99.00 |
| 2814 | MHY 553 |
From $104.50 |
| 3999 | Saroglitazar magnesium |
From $176.00 |
| 4430 | Indeglitazar |
From $88.00 |
