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Rosiglitazone
- BRL 49653 - Rezult - Rosiglizole - TDZ 01
- Soluble in DMSO
- MF: C18H19N3O3S
- MW: 357.43
Description
Rosiglitazone (BRL-49653) is a high-affinity PPARγ agonist and insulin-sensitizing thiazolidinedione. It activates PPARγ transcriptional programs that regulate adipogenesis, glucose metabolism and inflammatory gene expression.
PPARγ is a nuclear receptor central to adipocyte differentiation, insulin sensitivity and metabolic homeostasis. Rosiglitazone is a benchmark agonist for metabolic disease research, adipocyte biology and nuclear receptor assay validation.
Key Features
- High-affinity PPARγ agonist
- Reported Kd: 7 nM
- Promotes adipocyte differentiation in C3H10T1/2 stem-cell models
- Clinically validated insulin-sensitizer pharmacology
Applications
- PPARγ nuclear receptor pharmacology
- Adipogenesis and stem-cell differentiation studies
- Insulin resistance and metabolic disease models
- Transcriptional reporter and ligand-binding assays
More Information
| Parent CAS No. | 122320-73-4 |
|---|---|
| Chemical Name | 5-(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)benzyl)thiazolidine-2,4-dione |
| SMILES | S1C(CC2=CC=C(OCCN(C)C3=NC=CC=C3)C=C2)C(=O)NC1=O |
| MFCD | MFCD00871760 |
| InChi | InChI=1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,15H,10-12H2,1H3,(H,20,22,23) |
| InChiKey | YASAKCUCGLMORW-UHFFFAOYSA-N |
| CID | 77999 |
| Short Description | PPARγ agonist |
References
- Y.F. Zhang et al. Rosiglitazone, a Peroxisome Proliferator-Activated Receptor (PPAR)-γ Agonist, Attenuates Inflammation Via NF-κB Inhibition in Lipopolysaccharide-Induced Peritonitis. Inflammation. 2015 Jun 6.
- J.M. Lehmann et al. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J Biol Chem. 1995 Jun 2;270(22):12953-6.
- R.T. Nolte et al. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma. Nature. 1998 Sep 10;395(6698):137-43.
- J.C. de Groot et al. Structural characterization of amorfrutins bound to the peroxisome proliferator-activated receptor γ. J Med Chem. 2013 Feb 28;56(4):1535-43.
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