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Hydroxypioglitazone
- M-IV
- Parent CAS: 146062-44-4
- Soluble in DMSO
- MF: C19H20N2O4S.HCl
- MW: 408.9
Description
Hydroxypioglitazone (Compound M-IV) is an active hydroxylated metabolite of pioglitazone with PPARγ agonist activity. It supports studies of thiazolidinedione metabolism and PPARγ-dependent insulin-sensitizing mechanisms.
PPARγ activation regulates adipocyte differentiation, glucose uptake, lipid storage and inflammatory gene expression. Hydroxypioglitazone is useful for comparing parent-drug and metabolite contributions to PPARγ pharmacology and antidiabetic pathway activity.
Key Features
- Active pioglitazone metabolite
- PPARγ agonist activity
- Reported modest antihyperglycemic activity relative to pioglitazone
- Relevant to thiazolidinedione metabolic pharmacology
Applications
- PPARγ receptor pharmacology
- Pioglitazone metabolism studies
- Type 2 diabetes and insulin-sensitivity models
- Adipocyte differentiation and glucose uptake assays
More Information
| Parent CAS No. | 146062-44-4 |
|---|---|
| Chemical Name | 5-(4-(2-(5-(1-hydroxyethyl)pyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione hydrochloride |
| SMILES | S1C(CC2=CC=C(OCCC3=NC=C(C(O)C)C=C3)C=C2)C(=O)NC1=O.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C19H20N2O4S.ClH/c1-12(22)14-4-5-15(20-11-14)8-9-25-16-6-2-13(3-7-16)10-17-18(23)21-19(24)26-17;/h2-7,11-12,17,22H,8-10H2,1H3,(H,21,23,24);1H |
| InChiKey | SBHOQYCDAHAMDW-UHFFFAOYSA-N |
| CID | 86748889 |
| Short Description | PPARγ agonist |
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