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INT131
- AMG 131
- Soluble in DMSO
- MF: C21H12Cl4N2O3S
- MW: 514.21
Description
INT131 (AMG131) is a potent, non-thiazolidinedione selective PPARγ modulator (SPPARM) and partial agonist. It activates insulin-sensitizing PPARγ pathways while aiming to separate metabolic efficacy from classical full-agonist liabilities.
PPARγ controls adipocyte differentiation, glucose handling, lipid metabolism and inflammatory gene expression. INT131 is useful for studying selective nuclear receptor modulation in metabolic disease, insulin resistance and type 2 diabetes research models.
Key Features
- Selective PPARγ modulator and partial agonist
- Non-thiazolidinedione SPPARM pharmacology
- Relevant to insulin sensitization and glucose metabolism
- Useful nuclear receptor tool compound
Applications
- PPARγ reporter assays
- Adipocyte differentiation studies
- Insulin resistance model research
- Metabolic disease pharmacology
More Information
| Parent CAS No. | 315224-26-1 |
|---|---|
| Chemical Name | 2,4-dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide |
| SMILES | C1(S(NC2=CC(Cl)=C(OC3=CC4C(N=C3)=CC=CC=4)C(Cl)=C2)(=O)=O)=CC=C(Cl)C=C1Cl |
| MFCD | MFCD13152369 |
| InChi | InChI=1S/C21H12Cl4N2O3S/c22-13-5-6-20(16(23)8-13)31(28,29)27-14-9-17(24)21(18(25)10-14)30-15-7-12-3-1-2-4-19(12)26-11-15/h1-11,27H |
| InChiKey | NMRWDFUZLLQSBN-UHFFFAOYSA-N |
| CID | 10229498 |
| Short Description | PPARγ modulator |
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