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Indeglitazar
- PPM204
- Soluble in 0.1N NaOH(aq), DMSO and EtOH
- MF: C19H19NO6S
- MW: 389.42
Description
Indeglitazar is an orally available PPAR pan-agonist with EC50 values of 0.51, 0.37 and 2.7 μM for PPARα, PPARγ and PPARδ, respectively. Evaluation of Indeglitazar in vivo confirmed the reduced adiponectin response in animal models of obesity and diabetes while revealing strong beneficial effects on glucose, triglycerides, cholesterol, body weight, and other metabolic parameters.
More Information
| Parent CAS No. | 835619-41-5 |
|---|---|
| Chemical Name | 3-(5-Methoxy-1-(4-methoxyphenylsulfonyl)-3-indolyl)propionic acid |
| SMILES | C1=C2C(CCC(O)=O)=CN(S(=O)(=O)C3=CC=C(OC)C=C3)C2=CC=C1OC |
| MFCD | MFCD18633304 |
| InChi | InChI=1S/C19H19NO6S/c1-25-14-4-7-16(8-5-14)27(23,24)20-12-13(3-10-19(21)22)17-11-15(26-2)6-9-18(17)20/h4-9,11-12H,3,10H2,1-2H3,(H,21,22) |
| InChiKey | YMPALHOKRBVHOJ-UHFFFAOYSA-N |
| CID | 11395145 |
| Short Description | PPAR agonist |
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