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Saroglitazar magnesium
- ZYH1
- Parent CAS: 495399-09-2
- Optical Purity: 99% e.e.
- Soluble in DMSO
- MF: C25H28NO4S.0.5Mg
- MW: 450.71
Description
Saroglitazar magnesium is a potent dual PPAR agonist with predominant PPARα (EC50 value of 0.65 pM) and moderate PPARγ activity (EC50 value of 3 nM). Antidiabetic agent.
More Information
| Parent CAS No. | 495399-09-2 |
|---|---|
| Chemical Name | (S)-2-Ethoxy-3-(4-(2-(2-methyl-5-(4-(methylthio)phenyl)-1H-pyrrol-1-yl)ethoxy)phenyl)propanoic acid hemi-magnesium salt |
| SMILES | C1C(C2=CC=C(C)N2CCOC2C=CC(C[C@H](OCC)C(=O)[O-])=CC=2)=CC=C(SC)C=1.[Mg+2] |&1:16,r,Sg:n:0,1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30:2:ht| |
| MFCD | N.A. |
| InChi | InChI=1S/C25H29NO4S/c1-4-29-24(25(27)28)17-19-6-10-21(11-7-19)30-16-15-26-18(2)5-14-23(26)20-8-12-22(31-3)13-9-20/h5-14,24H,4,15-17H2,1-3H3,(H,27,28)/p-1/t24-/m0/s1 |
| InChiKey | MRWFZSLZNUJVQW-DEOSSOPVSA-M |
| CID | 140705194 |
| Short Description | PPARα/γ agonist |
References
- R Agrawal et al. The first approved agent in the Glitazar's Class: Saroglitazar. Curr Drug Targets. 2014 Feb;15(2):151-5.
- RH Jani et al. Pharmacokinetics, safety, and tolerability of saroglitazar (ZYH1), a predominantly PPARα agonist with moderate PPARγ agonist activity in healthy human subjects. Clin Drug Investig. 2013 Nov;33(11):809-16.
- MR Jain et al. Saroglitazar, a novel PPARα/γ agonist with predominant PPARα activity, shows lipid-lowering and insulin-sensitizing effects in preclinical models. Pharmacol Res Perspect. 2015 Jun;3(3):e00136.
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