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ZLN 005
Axon 2379
CAS:
49671-76-3
Purity:
99%
- Soluble in DMSO
- MF: C17H18N2
- MW: 250.34
Description
Selective transcriptional regulator of peroxisome proliferator–activated receptor-γ coactivator-1α (PGC-1α). ZLN005 selectively stimulated the expression of PGC-1α and downstream genes in skeletal muscle cells, and led to changes in glucose uptake, and fatty acid oxidation in L6 myotubes in a AMPK dependent manner. Since ZLN 005 did not increase the expression of the PGC-1α gene in rat primary hepatocytes, it is hypothesized that expression of PGC-1α was regulated in a cell type–specific manner. ZLN005 exerts promising therapeutic effects for treating type 2 diabetes, as PGC-1α is a powerful transcriptional coregulator of GLUT4 and mitochondrial genes, a crucial player in the field of glucose uptake in skeletal muscle.
More Information
| Parent CAS No. | 49671-76-3 |
|---|---|
| Chemical Name | 2-(4-tert-butylphenyl)-1H-benzo[d]imidazole |
| SMILES | C1(C2=CC=C(C(C)(C)C)C=C2)NC2=CC=CC=C2N=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C17H18N2/c1-17(2,3)13-10-8-12(9-11-13)16-18-14-6-4-5-7-15(14)19-16/h4-11H,1-3H3,(H,18,19) |
| InChiKey | LQUNNCQSFFKSSK-UHFFFAOYSA-N |
| CID | 899323 |
| Short Description | Regulator of PGC-1α |
References
- L.N. Zhang et al. Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice. Diabetes. 2013, 62, 1297-1307.
- L.N. Zhang et al. Novel small-molecule AMP-activated protein kinase allosteric activator with beneficial effects in db/db mice. PLoS One. 2013, 8, e72092.
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