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AdipoRon

Axon 2275
CAS:  924416-43-3
Purity:  99%
  • Soluble in 0.1N HCl(aq) and DMSO
  • MF:  C27H28N2O3
  • MW:  428.52

Description

AdipoRon is an orally active adiponectin receptor agonist with Kd values of 1.8 μM and 3.1 μM for AdipoR1 and AdipoR2, respectively. It activates AMPK and PPARα signaling pathways and improves insulin resistance, glucose intolerance and diabetes phenotypes in obese rodent models.

Adiponectin receptor signaling links adipose-derived endocrine regulation to glucose metabolism, fatty-acid oxidation and metabolic stress resistance. AdipoRon is useful for studying AdipoR pharmacology and antidiabetic pathway modulation.

Key Features

  • Orally active adiponectin receptor (AdipoR) agonist
  • Kd: 1.8 μM at AdipoR1 and 3.1 μM at AdipoR2
  • Activates AMPK and PPARα pathways
  • Improves metabolic phenotypes in obese rodent models

Applications

  • Adiponectin receptor pharmacology
  • Insulin-resistance studies
  • Glucose and lipid metabolism research
  • Type 2 diabetes model assays

More Information

Parent CAS No. 924416-43-3
Chemical Name 2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide
SMILES C(NC1CCN(CC2=CC=CC=C2)CC1)(=O)COC1=CC=C(C(=O)C2=CC=CC=C2)C=C1
MFCD N.A.
InChi InChI=1S/C27H28N2O3/c30-26(28-24-15-17-29(18-16-24)19-21-7-3-1-4-8-21)20-32-25-13-11-23(12-14-25)27(31)22-9-5-2-6-10-22/h1-14,24H,15-20H2,(H,28,30)
InChiKey SHHUPGSHGSNPDB-UHFFFAOYSA-N
CID 16307093
Short Description AdipoR agonist

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