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WZ 4003
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C25H29ClN6O3
- MW: 496.99
Description
Specific dual inhibitor of NUAK1 (aka ARK5) and NUAK2 (aka SNARK; IC50 values 20 nM and 100 nM, respectively) with no significant inhibitory effect on a panel of 139 other kinases tested, including ten other AMPK-related kinases. WZ4003 suppressed MYPT1 phosphorylation in a dose-dependent manner, and inhibited cell proliferation, invasion and migration in vivo.
Although WZ 4003 is a close analogue of WZ 4002 (Axon 1506), it shows no affinity for the EGFR (Kd value 14 µM)
More Information
| Parent CAS No. | 1214265-58-3 |
|---|---|
| Chemical Name | N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)propionamide |
| SMILES | C(=O)(NC1=CC=CC(OC2N=C(NC3=C(OC)C=C(C=C3)N3CCN(C)CC3)N=CC=2Cl)=C1)CC |
| MFCD | N.A. |
| InChi | InChI=1S/C25H29ClN6O3/c1-4-23(33)28-17-6-5-7-19(14-17)35-24-20(26)16-27-25(30-24)29-21-9-8-18(15-22(21)34-3)32-12-10-31(2)11-13-32/h5-9,14-16H,4,10-13H2,1-3H3,(H,28,33)(H,27,29,30) |
| InChiKey | SDGJBAUIGHSMRI-UHFFFAOYSA-N |
| CID | 72200024 |
| Short Description | NUAK inhibitor |
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