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ZLN 024
Axon 2445
CAS:
723249-01-2
Purity:
100%
- Soluble in DMSO
- MF: C13H13BrN2OS
- MW: 325.22
Description
ZLN 024 is an allosteric activator of AMP-activated protein kinase (AMPK). It activates AMPK heterotrimers without directly affecting mitochondrial function or cellular AMP/ATP ratios in reported studies.
AMPK is a central metabolic sensor that coordinates glucose uptake, fatty-acid oxidation, mitochondrial homeostasis and energy stress responses. ZLN 024 is useful for studying AMPK activation in metabolic and cardiometabolic research models.
Key Features
- Allosteric AMPK activator
- Reported EC50 values: 0.42 µM for α1β1γ1 and 0.95 µM for α2β1γ1 AMPK
- Activates AMPK without directly altering mitochondrial respiration in reported assays
- Modulates metabolic signaling and energy homeostasis pathways
Applications
- AMPK pathway research
- Metabolic disease and glucose homeostasis models
- Energy-stress signaling assays
- Cardiometabolic pharmacology studies
More Information
| Parent CAS No. | 723249-01-2 |
|---|---|
| Chemical Name | 2-(2-(2-bromo-4-methylphenoxy)ethylthio)pyrimidine |
| SMILES | C1(SCCOC2=CC=C(C)C=C2Br)=NC=CC=N1 |
| MFCD | N.A. |
| InChi | InChI=1S/C13H13BrN2OS/c1-10-3-4-12(11(14)9-10)17-7-8-18-13-15-5-2-6-16-13/h2-6,9H,7-8H2,1H3 |
| InChiKey | KWJRSHZSULRJHE-UHFFFAOYSA-N |
| CID | 1825716 |
| Short Description | AMPK activator |
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