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IMS 2186
Axon 1827
CAS:
1031206-36-6
Purity:
99%
- Soluble in DMSO
- MF: C18H16O4
- MW: 296.32
Description
IMS 2186 is an anti-proliferative and anti-angiogenic compound reported to induce apoptosis, block the cell cycle at G2 and inhibit production of inflammatory mediators including PGE2 and TNF-α.
IMS 2186 has been investigated as a long-acting small-molecule approach to choroidal neovascularization and other angiogenesis-linked processes. It is useful for studying links between cell-cycle control, apoptosis and inflammatory mediator production.
Key Features
- Apoptosis-inducing anti-proliferative compound
- Blocks cell-cycle progression at G2
- Reported to inhibit PGE2 and TNF-α production
- Relevant to anti-angiogenic and anti-CNV research
Applications
- Cell-cycle arrest and apoptosis studies
- Anti-angiogenesis assay development
- PGE2 and TNF-α mediator profiling
- Choroidal neovascularization research models
More Information
| Parent CAS No. | 1031206-36-6 |
|---|---|
| Chemical Name | (E)-3-(3-hydroxy-4-methoxybenzylidene)-6-methylchroman-4-one |
| SMILES | C1OC2=CC=C(C)C=C2C(=O)/C/1=C/C1=CC=C(OC)C(O)=C1 |
| MFCD | MFCD12912419 |
| InChi | InChI=1S/C18H16O4/c1-11-3-5-16-14(7-11)18(20)13(10-22-16)8-12-4-6-17(21-2)15(19)9-12/h3-9,19H,10H2,1-2H3/b13-8+ |
| InChiKey | BZCADTHMZLYKAR-MDWZMJQESA-N |
| CID | 24987039 |
| Short Description | G2/PGE2 inhibitor |
IMS 2186
cell-cycle progression at G2 blocker
IMS2186
cell-cycle progression at G2
Blocker
Cell-cycle arrest and apoptosis studies
Anti-angiogenesis assay development
PGE2 and TNF-α mediator profiling
Choroidal neovascularization research models
apoptosis
cell cycle
angiogenesis
inflammation
immunology
CAS 1031206-36-6
Axon Medchem
Axon 1827
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