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NEO 212
- TMZ-POH
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C17H20N6O4
- MW: 372.38
Description
NEO 212 (TMZ-POH) is a DNA-alkylating agent formed by conjugating temozolomide (TMZ, Axon 2326) with perillyl alcohol (POH). It produces DNA damage and cell death more efficiently than temozolomide in reported models, with IC50 values of 5–50 μM in glioma cell lines and activity against temozolomide-resistant cancer cells.
Temozolomide resistance is a major limitation in glioma and other oncology models. NEO 212 is useful for studying DNA alkylation, resistance circumvention and improved pharmacological exposure through TMZ–POH conjugation.
Key Features
- Temozolomide–perillyl alcohol (TMZ-POH) conjugate
- DNA alkylating antitumor agent
- IC50: 5–50 μM in glioma cell lines
- Circumvents temozolomide resistance in reported models
Applications
- DNA alkylation research
- Glioma and brain tumor models
- Temozolomide-resistance studies
- Triple-negative breast cancer pharmacology
More Information
| Parent CAS No. | 1361198-79-9 |
|---|---|
| Chemical Name | (S)-(4-(Prop-1-en-2-yl)cyclohex-1-enyl)methyl 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbonylcarbamate |
| SMILES | C(OCC1CC[C@]([H])(C(C)=C)CC=1)(=O)NC(C1=C2N(C=N1)C(=O)N(C)N=N2)=O |&1:6,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C17H20N6O4/c1-10(2)12-6-4-11(5-7-12)8-27-16(25)19-15(24)13-14-20-21-22(3)17(26)23(14)9-18-13/h4,9,12H,1,5-8H2,2-3H3,(H,19,24,25)/t12-/m1/s1 |
| InChiKey | MGTLGARADRIKNV-GFCCVEGCSA-N |
| CID | 56846912 |
| Short Description | DNA alkylating agent |
References
- T.C. Chen et al. A novel temozolomide-perillyl alcohol conjugate exhibits superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo. Mol. Cancer Ther. 2014, 13, 1181-1193.
- H.Y. Cho et al. NEO212, temozolomide conjugated to perillyl alcohol, is a novel drug for effective treatment of a broad range of temozolomide-resistant gliomas. Mol. Cancer Ther. 2014, 13, 2004-2017.
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