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SB 202190
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C20H14FN3O
- MW: 331.34
Description
SB 202190 is a potent, cell-permeable and selective p38 mitogen-activated protein kinase (p38 MAPK) inhibitor. SB202190 specifically blocks the p38 MAPK signaling without altering ERK or JNK signaling pathways. SB202190 is widely used as a pharmacological tool to investigate the role of p38-dependent pathways in inflammation, cellular stress responses, apoptosis, and cytokine production.
In recent stem cell research, SB202190 is frequently used to promote self-renewal, maintain naive pluripotency, or guide cell differentiation.
Key Features
- Specific p38 MAPK inhibitor
- No inhibition on ERK and JNK kinases
- Widely used research tool in stem cell research
- Useful for inflammation and stress response studies
Applications
- p38 MAPK signaling research
- Stem Cell Research
- Apoptosis and cell survival research
- Immunology and signal transduction studies
More Information
| Parent CAS No. | 152121-30-7 |
|---|---|
| Chemical Name | 4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-2-yl]-phenol |
| SMILES | N1C=CC(C2NC(C3C=CC(O)=CC=3)=NC=2C2C=CC(F)=CC=2)=CC=1 |
| MFCD | MFCD00941964 |
| InChi | InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24) |
| InChiKey | QHKYPYXTTXKZST-UHFFFAOYSA-N |
| CID | 5169 |
| Short Description | p38 MAPK inhibitor |
References
- PC Singhal et al. Role of P38 Mitogen-Activated Protein Kinase Phosphorylation and Fas-Fas Ligand Interaction in Morphine-Induced Macrophage Apoptosis. J. Immunol. 2002, 168, 4025-4033.
- PR Young et al. Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site. J. Biol. Chem. 1997, 272, 12116-12121.
- S Nemoto et al. Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase. J. Biol. Chem. 1998, 273, 16415-16420.
- List of publications using SB 202190 (Axon 1364) purchased from Axon Medchem
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