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PD184352
- CI 1040
- Soluble in DMSO
- MF: C17H14ClF2IN2O2
- MW: 478.66
Description
PD184352 (CI-1040) is a potent, selective and non-competitive MEK inhibitor that blocks MEK activation and downstream ERK1/2 signaling. PD184352 was one of the first highly selective MEK inhibitors developed and remains a widely used tool compound for investigating the MAPK/ERK signaling pathway.
The MEK/ERK pathway regulates cell proliferation, differentiation, survival, and developmental signaling and is frequently dysregulated in cancer. PD184352 effectively suppresses MAPK signaling and has been extensively used in oncology, signal transduction, and stem cell research. In combination with SU5402 (Axon 1667) and CHIR99021 (Axon 1386), PD184352 forms the conventional 3i stem cell culture system (Axon 2129), which supports mouse embryonic stem cell (mESC) self-renewal and maintenance of pluripotency under defined culture conditions. PD184352 also served as the lead compound for the development of PD0325901 (Axon 1408).
Key Features
- Potent and selective non-competitive MEK inhibitor
- Suppresses ERK1/2 phosphorylation and MAPK signaling
- Widely used tool for MEK/ERK pathway research
- Core component of the conventional 3i stem cell culture system
Applications
- MEK/ERK and MAPK signaling research
- Cancer biology and signal transduction studies
- Embryonic stem cell maintenance and self-renewal research
- Used in stem cell culture and pluripotency studies
- Developmental biology and cellular reprogramming investigations
*Promotion: PD184352 is also part of Inhibitor Set(s):
| Stem Cell 3i inhibitor Set (Axon 2129) |
More Information
| Parent CAS No. | 212631-79-3 |
|---|---|
| Chemical Name | 2-(2-Chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide |
| SMILES | C1C(Cl)=C(NC2C(C(=O)NOCC3CC3)=CC=C(F)C=2F)C=CC=1I |
| MFCD | MFCD02683961 |
| InChi | InChI=1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24) |
| InChiKey | GFMMXOIFOQCCGU-UHFFFAOYSA-N |
| CID | 91826459 |
| Short Description | MEK1 inhibitor |
References
- RR Mattingly et al. The MEK inhibitor PD184352/CI-1040 selectively induces apoptosis in malignant schwannoma cell lines. J. Pharmacol. Exp. Ther. 2006, 316, 456-465.
- D Liu et al. Inhibitory Effects of the Mitogen-Activated Protein Kinase Kinase Inhibitor CI-1040 on the Proliferation and Tumor Growth of Thyroid Cancer Cells with BRAF or RAS Mutations. J. Clin. Endocrinol. & Meta. 2007, 92 (12), 4686-4695.
- QL Ying et al. The ground state of embryonic stem cell self-renewal. Nature, 2008, 453, 519-523.
- List of publications using PD184352 (Axon 1368) purchased from Axon Medchem
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