MEK

Four distinct MAPK cascades have been identified and named according to their MAPK module. These are extra-cellular signal-regulated kinase (ERK1/2), c-Jun N-terminal kinase (JNK), p38 and ERK5. MEK proteins (EC 2.7.12.1) belong to a family of enzymes that lie upstream to their specific MAPK targets in MAP kinase signaling pathways, and so far 7 MEK enzymes have been identified. MEK1 and MEK2 are closely related. They both participate in the Ras/Raf/MEK/ERK signal transduction cascade. MEK1 (a.k.a. MAPKK-1 or MAP2K1) is the prototype member of MEK family proteins[1].


[1] A. Akinleye et al. MEK and the inhibitors: from bench to bedside. J. Hematol. Oncol. 2013, 6, 27-38.

15 Item(s)

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Axon ID Name Description From price
1516 AZD 6244 MEK1 and MEK2 inhibitor €70.00
1999 AZD 8330 MEK 1 inhibitor €105.00
1808 BIX 02188 MEK5 inhibitor; ERK5 inhibitor €125.00
1809 BIX 02189 MEK5 inhibitor; ERK5 inhibitor €125.00
1761 GSK 1120212 MEK1 and MEK2 inhibitor €95.00
5011 Naive Stem Cell 5i inhibitor Set Set of five inhibitors for the induction and maintenance of human naive stem cell pluripotency €240.00
5010 Naive Stem Cell NHSM inhibitor Set Set of inhibitors for isolation, generation, derivatization and stabilization of naive hPSCs €275.00
1408 PD 0325901 MEK1 and MEK2 inhibitor €60.00
1368 PD 184352 MEK 1 inhibitor €85.00
1223 PD 98059 MEK inhibitor €80.00
1122 SL 327 MEK1 and MEK2 inhibitor €80.00
2128 Stem Cell 2i inhibitor Set Set of MEK inhibitor PD0325901 (Axon 1408) and GSK-3 inhibitor CHIR99021 (Axon 1386) €110.00
2129 Stem Cell 3i inhibitor Set Set of FGFR inhibitor SU5402 (Axon 1667), MEK inhibitor PD184352 (Axon 1368) and GSK-3 inhibitor CHIR99021 (Axon 1386) €155.00
5009 Stem Cell 4i inhibitor Set Set of Thiazovivin, SB 431542, PD 0325901, and CHIR 99021 (inhibitors of ROCK, TGF-β, MEK, and GSK-3 resp.) €200.00
2520 U 0126 Non-competitive inhibitor of MEK1/2 and protects brain in stroke models €90.00

15 Item(s)

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