Four distinct MAPK cascades have been identified and named according to their MAPK module. These are extra-cellular signal-regulated kinase (ERK1/2), c-Jun N-terminal kinase (JNK), p38 and ERK5. MEK proteins (EC belong to a family of enzymes that lie upstream to their specific MAPK targets in MAP kinase signaling pathways, and so far 7 MEK enzymes have been identified. MEK1 and MEK2 are closely related. They both participate in the Ras/Raf/MEK/ERK signal transduction cascade. MEK1 (a.k.a. MAPKK-1 or MAP2K1) is the prototype member of MEK family proteins[1].

[1] A. Akinleye et al. MEK and the inhibitors: from bench to bedside. J. Hematol. Oncol. 2013, 6, 27-38.

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Axon ID Name Description From price
1516 AZD6244 MEK1 and MEK2 inhibitor €60.00
1999 AZD8330 MEK 1 inhibitor €105.00
3697 Binimetinib Potent, selective, non-ATP-competitive and orally available allosteric inhibitor of MEK1/2 €60.00
1809 BIX 02189 MEK5 inhibitor; ERK5 inhibitor €110.00
3346 BIX02188 Potent MEK5 inhibitor €110.00
1808 BIX02188-Me MEK5 inhibitor; ERK5 inhibitor €110.00
4148 GDC-0973 Orally bioavailable, potent and selective small-molecule inhibitor of mitogen-activated protein kinase 1 Inquire
1761 GSK 1120212 MEK1 and MEK2 inhibitor €70.00
3059 GW 284543 hydrochloride Selective MEK5 inhibitor €95.00
5011 Naive Stem Cell 5i inhibitor Set Set of five inhibitors for the induction and maintenance of human naive stem cell pluripotency €200.00
5010 Naive Stem Cell NHSM inhibitor Set Set of inhibitors for isolation, generation, derivatization and stabilization of naive hPSCs €230.00
1408 PD0325901 MEK1 and MEK2 inhibitor €50.00
1368 PD184352 MEK 1 inhibitor €80.00
1223 PD98059 MEK inhibitor €80.00
3874 RDEA119 Potent and highly selective small molecule allosteric MEK inhibitor Inquire
1122 SL 327 MEK1 and MEK2 inhibitor €80.00
2128 Stem Cell 2i inhibitor Set Set of MEK inhibitor PD0325901 (Axon 1408) and GSK-3 inhibitor CHIR99021 (Axon 1386) €90.00
2129 Stem Cell 3i inhibitor Set Set of FGFR inhibitor SU5402 (Axon 1667), MEK inhibitor PD184352 (Axon 1368) and GSK-3 inhibitor CHIR99021 (Axon 1386) €130.00
5009 Stem Cell 4i inhibitor Set Set of Thiazovivin, SB 431542, PD0325901, and CHIR99021 (inhibitors of ROCK, TGF-β, MEK, and GSK-3 resp.) €170.00
2520 U 0126 Non-competitive inhibitor of MEK1/2 and protects brain in stroke models €90.00

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