MEK
Four distinct MAPK cascades have been identified and named according to their MAPK module. These are extra-cellular signal-regulated kinase (ERK1/2), c-Jun N-terminal kinase (JNK), p38 and ERK5. MEK proteins (EC 2.7.12.1) belong to a family of enzymes that lie upstream to their specific MAPK targets in MAP kinase signaling pathways, and so far 7 MEK enzymes have been identified. MEK1 and MEK2 are closely related. They both participate in the Ras/Raf/MEK/ERK signal transduction cascade. MEK1 (a.k.a. MAPKK-1 or MAP2K1) is the prototype member of MEK family proteins[1].
[1] A. Akinleye et al. MEK and the inhibitors: from bench to bedside. J. Hematol. Oncol. 2013, 6, 27-38.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 4217 | AS-703026 | Potent, selective and orally bioavailable small molecular inhibitor of MEK1/2 | Inquire | |
| 1516 | AZD6244 | MEK1 and MEK2 inhibitor | €60.00 | |
| 1999 | AZD8330 | MEK 1 inhibitor | €105.00 | |
| 3697 | Binimetinib | Potent, selective, non-ATP-competitive and orally available allosteric inhibitor of MEK1/2 | €60.00 | |
| 1809 | BIX 02189 | MEK5 inhibitor; ERK5 inhibitor | €110.00 | |
| 3346 | BIX02188 | Potent MEK5 inhibitor | €110.00 | |
| 1808 | BIX02188-Me | MEK5 inhibitor; ERK5 inhibitor | €110.00 | |
| 4148 | GDC-0973 | Orally bioavailable, potent and selective small-molecule inhibitor of mitogen-activated protein kinase 1 | Inquire | |
| 1761 | GSK 1120212 | MEK1 and MEK2 inhibitor | €70.00 | |
| 3059 | GW 284543 hydrochloride | Selective MEK5 inhibitor | €95.00 | |
| 5011 | Naive Stem Cell 5i inhibitor Set | Set of five inhibitors for the induction and maintenance of human naive stem cell pluripotency | €200.00 | |
| 5010 | Naive Stem Cell NHSM inhibitor Set | Set of inhibitors for isolation, generation, derivatization and stabilization of naive hPSCs | €230.00 | |
| 1408 | PD0325901 | MEK1 and MEK2 inhibitor | €50.00 | |
| 1368 | PD184352 | MEK 1 inhibitor | €80.00 | |
| 1223 | PD98059 | MEK inhibitor | €80.00 | |
| 3874 | RDEA119 | Potent and highly selective small molecule allosteric MEK inhibitor | Inquire | |
| 1122 | SL 327 | MEK1 and MEK2 inhibitor | €80.00 | |
| 2128 | Stem Cell 2i inhibitor Set | Set of MEK inhibitor PD0325901 (Axon 1408) and GSK-3 inhibitor CHIR99021 (Axon 1386) | €90.00 | |
| 2129 | Stem Cell 3i inhibitor Set | Set of FGFR inhibitor SU5402 (Axon 1667), MEK inhibitor PD184352 (Axon 1368) and GSK-3 inhibitor CHIR99021 (Axon 1386) | €130.00 | |
| 5009 | Stem Cell 4i inhibitor Set | Set of Thiazovivin, SB 431542, PD0325901, and CHIR99021 (inhibitors of ROCK, TGF-β, MEK, and GSK-3 resp.) | €170.00 | |
| 2520 | U 0126 | Non-competitive inhibitor of MEK1/2 and protects brain in stroke models | €90.00 | |