MAPK (p38)

To date, five distinct groups of mitogen activated protein kinases (MAPKs) have been characterized in mammals: extracellular signal-regulated kinases (ERKs) 1 and 2 (ERK1/2), c-Jun amino-terminal kinases (JNKs) 1, 2, and 3, p38 isoforms α, β, γ, and δ , ERKs 3 and 4, and ERK5; all sharing the enzyme commission number EC 2.7.11.24. MAPKs can be activated by a wide variety of different stimuli, but in general, ERK1 and ERK2 are preferentially activated in response to growth factors and phorbol esters, while the JNK and p38 kinases are more responsive to stress stimuli ranging from osmotic shock and ionizing radiation to cytokine stimulation. Although each MAPK has unique characteristics, a number of features are shared by the MAPK pathways studied to date. Each family of MAPKs is composed of a set of three sequentially acting kinases: a MAPK, a MAPK kinase (MAPKK or MAP2K), and a MAPKK kinase (MAPKKK or MAP3K). p38 (also known as CSBP, mHOG1, RK, and SAPK2) is the archetypal member of the second MAPK-related pathway in mammalian cells. The p38 module consists of several MAPKKKs, including MEKKs 1-4, MLK2 and -3, DLK, ASK1, Tpl2 (a.k.a. Cot), and Tak1, the MAPKKs MEK3 and MEK6 (a.k.a. MKK3 and MKK6, resp.), and the four known p38 isoforms (α, β, γ, and δ). In mammalian cells, the p38 isoforms are strongly activated by environmental stresses and inflammatory cytokines but not appreciably by mitogenic stimuli. Most stimuli that activate p38 also activate JNK, but only p38 is inhibited by the anti-inflammatory drug SB203580 (Axon 1363 and Axon 1465 (HCl salt; water soluble), which has been extremely useful in delineating the function of p38[1].

MAPK subclasses listed: MAPK (JNK), MAPK (p38), ERK


[1] P.P. Roux, J. Blenis. ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions. Microbiol. Mol. Biol. Rev. June 2004, 68, 320-344.

12 Item(s)

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Axon ID Name Description From price
1358 BIRB 796 MAPK inhibitor (p38 specific) €70.00
1895 LY 2228820 Inhibitor of p38 MAPK €105.00
5010 Naive Stem Cell NHSM inhibitor Set Set of inhibitors for isolation, generation, derivatization and stabilization of naive hPSCs €275.00
1365 PD 169316 MAPK inhibitor (p38 specific) €50.00
1837 PH 797804 Inhibitor of p38α MAPK €115.00
1364 SB 202190 MAPK inhibitor (p38 specific) €95.00
1363 SB 203580 MAPK inhibitor (p38 specific) €95.00
1465 SB 203580 hydrochloride MAPK inhibitor (p38 specific) €70.00
2444 SB 706504 Selective p38 MAPK inhibitor that targets a subset of inflammatory macrophage genes. €125.00
1671 SCIO 469 MAPK inhibitor (p38 specific) €105.00
1357 SD-169 MAPK inhibitor (p38α specific) €60.00
1811 VX 745 Inhibitor of p38α MAP kinase €90.00

12 Item(s)

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