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SB 203580 hydrochloride
- Parent CAS: 152121-47-6
- Soluble in water
- MF: C21H16FN3OS.HCl
- MW: 413.9
Description
SB 203580 hydrochloride is the water-soluble hydrochloride salt of SB 203580, a potent, cell-permeable and selective p38 mitogen-activated protein kinase (p38 MAPK) inhibitor. SB 203580 hydrochloride retains the biological activity of the parent compound while offering improved aqueous solubility for experimental applications.
The p38 MAPK pathway is activated by inflammatory cytokines, cellular stress, and environmental stimuli and regulates cytokine production, apoptosis, proliferation, and differentiation. SB 203580 hydrochloride is widely used to investigate p38-dependent signaling in inflammation, immune responses, stress signaling, and disease biology. In addition, inhibition of p38 signaling has important applications in stem cell research, where modulation of p38 activity can influence pluripotency, self-renewal, differentiation, and cellular reprogramming. The water-soluble salt form provides a convenient alternative for studies requiring aqueous formulations.
Key Features
- Water-soluble hydrochloride salt of SB 203580
- Potent and selective p38 MAPK inhibitor
- Cell-permeable small molecule inhibitor
- Suitable for inflammation and signaling research
- Useful in stem cell and developmental biology studies
Applications
- p38 MAPK signaling research
- Inflammation and cytokine signaling studies
- Stem cell differentiation and pluripotency research
- Cellular stress response investigations
- Developmental biology and regenerative medicine studies
Related Products
SB 203580 (Axon 1363) is the parent free-base form of this compound. Researchers interested in broader and more potent p38 MAPK inhibition may also consider BIRB 796 (Axon 1358), an inhibitor with activity against all four p38 MAPK isoforms.
More Information
| Parent CAS No. | 152121-47-6 |
|---|---|
| Chemical Name | 4-(4-(4-Fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-5-yl)pyridine hydrochloride |
| SMILES | N1C=CC(C2NC(C3C=CC(S(=O)C)=CC=3)=NC=2C2C=CC(F)=CC=2)=CC=1.Cl |
| MFCD | MFCD00922198 |
| InChi | InChI=1S/C21H16FN3OS.ClH/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15;/h2-13H,1H3,(H,24,25);1H |
| InChiKey | WOSGGXINSLMASH-UHFFFAOYSA-N |
| CID | 16760644 |
| Short Description | p38 MAPK inhibitor |
References
- PC Singhal et al. Role of P38 Mitogen-Activated Protein Kinase Phosphorylation and Fas-Fas Ligand Interaction in Morphine-Induced Macrophage Apoptosis. J. Immunol. 2002, 168, 4025-4033.
- PR Young et al. Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site. J. Biol. Chem. 1997, 272, 12116-12121.
- H Kankaanranta et al. SB 203580, an Inhibitor of p38 Mitogen-Activated Protein Kinase, Enhances Constitutive Apoptosis of Cytokine-Deprived Human Eosinophils. J. Pharm. Exp. Ther. 1999, 290, 2, 621-628.
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