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VX 745
- Soluble in DMSO
- MF: C19H9Cl2F2N3OS
- MW: 436.26
Description
VX 745 is a highly potent and selective p38α MAP kinase inhibitor with a reported IC50 value of 10 nM being 1000 fold selective over closely related kinases..
p38α/MAPK14 is activated by inflammatory cytokines, stress stimuli and tissue injury, driving downstream transcriptional and cytokine responses. VX 745 is useful for studying p38-dependent inflammation and stress-activated kinase signaling.
Key Features
- Potent p38α/MAPK14 inhibitor
- Reported IC50: 10 nM
- Shows strong selectivity over closely related kinases
- Relevant to inflammatory cytokine and stress-response signaling
Applications
- p38 MAPK pathway studies
- Inflammatory cytokine signaling assays
- Stress-activated kinase research
- Neuroinflammation and disease-pathway models
More Information
| Parent CAS No. | 209410-46-8 |
|---|---|
| Chemical Name | 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one |
| SMILES | C12=C(C3=C(Cl)C=CC=C3Cl)C(=O)N=CN1N=C(SC1=CC=C(F)C=C1F)C=C2 |
| MFCD | MFCD09834070 |
| InChi | InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H |
| InChiKey | VEPKQEUBKLEPRA-UHFFFAOYSA-N |
| CID | 3038525 |
| Short Description | p38α MAPK inhibitor |
References
- JP Duffy et al. The discovery of VX-745: a novel and selective p38α kinase inhibitor. ACS Med. Chem. Lett. 2011, 2, 758.
- MC Bagley et al. Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells. Bioorg. Med. Chem. Lett. 2007, 17(8), 5107-5110.
- JJ Haddad. VX-745. Vertex Pharmaceuticals. Curr. Opin. Investig. Drugs. 2001, 2(8), 1070-1076.
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