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SCIO 469
- Talmapimod
- Soluble in DMSO
- MF: C27H30ClFN4O3
- MW: 513
Description
SCIO 469 is an orally available and selective p38α MAP kinase inhibitor with approximately 10-fold selectivity over p38β and strong selectivity versus a broad kinase panel.
p38 MAPK signaling regulates inflammatory cytokine production, stress responses and tumor microenvironment biology. SCIO 469 is useful for dissecting p38α-dependent inflammatory and antineoplastic pathways.
Key Features
- Selective p38α MAPK inhibitor
- Approximately 10-fold selective for p38α over p38β
- Highly selective versus a broad kinase panel
- Relevant to inflammatory and cancer signaling models
Applications
- p38 MAPK pathway research
- Cytokine and inflammatory signaling assays
- Stress-response kinase studies
- Immunomodulatory and oncology pharmacology
More Information
| Parent CAS No. | 309913-83-5 |
|---|---|
| Chemical Name | 2-(6-chloro-5-((2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpiperazine-1-carbonyl)-1-methyl-1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide |
| MFCD | MFCD11973651 |
| Short Description | p38α MAPK inhibitor |
References
- SN Nikas and AA Drosos. SCIO-469 Scios Inc. Curr Opin Investig Drugs. 2004, 5(11), 1205-1212.
- SN Nikas and AA Drosos. SCIO-469 Scios Inc. Curr Opin Investig Drugs. 2004, 5(11), 1205-1212.
- T Navas et al. The p38 MAPK inhibitor SCIO-469 enhances the apoptotic and anti-proliferative effects of proteasome inhibitors MG132 and PS341 (Velcade) in multiple myeloma cells. Proc. Amer. Assoc. Cancer Res, 2004, Vol. Abs. #3350.
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