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NG 25 trihydrochloride
- Parent CAS: 1315355-93-1
- Soluble in water and DMSO
- MF: C29H30F3N5O2.3HCl
- MW: 646.96
Description
Type II inhibitor of TAK1 (MAP3K7) and MAP4K2 (GCK) with nanomolar potency for a wider range of kinases (IC50 values 13 nM, 22 nM, 56 nM, 75 nM, 82 nM, 102 nM, 113 nM, and 149 nM for LYN, MAP4K2, CSK, Abl, FER, p38α, SRC, and TAK1, repectively). At 0.1 µM NG25 shows strong inhibition of TAK1, Lck, MAP4K2, p38α, Abl, YES1, and OSR1. NG 25 potently inhibited the activation of IKKβ by TLR7 and TLR9 agonists and prevented the secretion of type 1 IFNs induced by these ligands in Gen2.2 cells.
More Information
| Parent CAS No. | 1315355-93-1 |
|---|---|
| Chemical Name | 3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide trihydrochloride |
| SMILES | C12C=CNC1=NC=CC=2OC1C(C)=CC=C(C(NC2C=C(C(F)(F)F)C(CN3CCN(CC)CC3)=CC=2)=O)C=1.Cl.Cl.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C29H30F3N5O2.3ClH/c1-3-36-12-14-37(15-13-36)18-21-6-7-22(17-24(21)29(30,31)32)35-28(38)20-5-4-19(2)26(16-20)39-25-9-11-34-27-23(25)8-10-33-27;;;/h4-11,16-17H,3,12-15,18H2,1-2H3,(H,33,34)(H,35,38);3*1H |
| InChiKey | QOIOJVPRHIAONM-UHFFFAOYSA-N |
| CID | 91826514 |
| Short Description | TAK1 (MAP3K7) and MAP4K2 inhibitor |
References
- L. Tan et al. Discovery of Type II Inhibitors of TGFβ-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2). J. Med. Chem. 2014 Jul 30. [Epub ahead of print]
- E. Pauls et al. Essential role for IKKβ in production of type 1 interferons by plasmacytoid dendritic cells. J. Biol. Chem. 2012, 287, 19216-19228.
- N. Dzamko et al. The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling. PLoS One. 2012, 7, e39132.
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