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PD169316
- Soluble in DMSO
- MF: C20H13FN4O2
- MW: 360.34
Description
PD169316 is a potent, cell-permeable p38 mitogen-activated protein kinase (MAPK) inhibitor that suppresses stress- and cytokine-responsive p38 signaling.
p38 MAPK regulates inflammatory mediator production, cellular stress adaptation and apoptosis. PD169316 is used to determine the contribution of p38 signaling to trophic-factor withdrawal, inflammatory responses and neuronal or non-neuronal cell death.
Key Features
- Cell-permeable p38 MAPK inhibitor
- Blocks stress-activated p38 signaling
- Reported to reduce apoptosis after trophic-factor withdrawal
- Useful for inflammatory and cell-survival pathway analysis
Applications
- p38 MAPK pathway assays
- Cytokine and inflammatory signaling studies
- Apoptosis and trophic-factor withdrawal models
- Neuronal stress and survival research
More Information
| Parent CAS No. | 152121-53-4 |
|---|---|
| Chemical Name | 4-[4-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl]pyridine |
| SMILES | C1(C2=NC(C3C=CC(F)=CC=3)=C(C3C=CN=CC=3)N2)C=CC([N+]([O-])=O)=CC=1 |
| MFCD | MFCD12405019 |
| InChi | InChI=1S/C20H13FN4O2/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(8-4-15)25(26)27/h1-12H,(H,23,24) |
| InChiKey | BGIYKDUASORTBB-UHFFFAOYSA-N |
| CID | 4712 |
| Short Description | p38 MAPK inhibitor |
References
- DJ. Samuvel et al. A Role for p38 Mitogen-Activated Protein Kinase in the Regulation of the Serotonin Transporter: Evidence for Distinct Cellular Mechanisms Involved in Transporter Surface Expression. J. Neuroscience, 2005, 25(1), 29-41.
- Y Fu et al. The p38 MAPK inhibitor, PD169316, inhibits transforming growth factor beta-induced Smad signaling in human ovarian cancer cells. Biochem. Biophys. Res. Commun. 2003, 310(2), 391-7.
- JL Kummer et al. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. J. Biol. Chem. 1997, 272(33), 20490-20494.
- R Nath et al. Inhibition of p38 kinase mimics survival signal-linked protection against apoptosis in rat cerebellar granule neurons. Cell Mol. Biol. Lett. 2001, 6,173-184.
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