Bulk Inquiry
AZD7762 hydrochloride
- Parent CAS: 860352-01-8
- Optical Purity: >98% e.e.
- Soluble in water and DMSO
- MF: C17H19FN4O2S.HCl
- MW: 398.88
Description
AZD7762 hydrochloride is a potent checkpoint kinase 1 and 2 inhibitor with reported IC50 values of approximately 5 nM for both CHK1 and CHK2.
AZD7762 suppresses DNA-damage checkpoint signaling, promotes premature cell-cycle progression and enhances the cytotoxicity of genotoxic agents. It is used to investigate checkpoint dependency, replication stress and radiosensitization.
Key Features
- Potent dual CHK1/CHK2 inhibitor
- Reported IC50: approximately 5 nM
- Abrogates S- and G2-phase DNA-damage checkpoints
- Sensitizes cells to chemotherapy and radiation
Applications
- CHK1 and CHK2 kinase assays
- DNA-damage checkpoint research
- Replication-stress and cell-cycle studies
- Chemo- and radiosensitization models
More Information
| Parent CAS No. | 860352-01-8 |
|---|---|
| Chemical Name | 5-(3-Fluoro-phenyl)-3-ureido-thiophene-2-carboxylic acid (S)-piperidin-3-ylamide hydrochloride |
| SMILES | C1(NC(N)=O)=C(C(N[C@H]2CCCNC2)=O)SC(C2C=CC=C(F)C=2)=C1.Cl |&1:8,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C17H19FN4O2S.ClH/c18-11-4-1-3-10(7-11)14-8-13(22-17(19)24)15(25-14)16(23)21-12-5-2-6-20-9-12;/h1,3-4,7-8,12,20H,2,5-6,9H2,(H,21,23)(H3,19,22,24);1H/t12-;/m0./s1 |
| InChiKey | WFZBLOIXZRZEDG-YDALLXLXSA-N |
| CID | 56972142 |
| Short Description | CHK inhibitor |
References
- JW Janetka et al, Inhibitors of Checkpoint Kinases: From discovery to the clinic. Curr. Opin. Drug Discov. & Devel. 2007, 10(4), 473-486.
- S. Ashwell and S Zabludoff. DNA Damage Detection and Repair Pathways Recent Advances with Inhibitors of Checkpoint Kinases in Cancer Therapy. Clin. Cancer Res. 2008, 14(13), 4033-4037.
- SD Zabludoff et al. AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies. Mol. Cancer Ther. 2008, 7(9), 2955-2966.
- L Carrassa et al. Role of Chk1 in the differentiation program of hematopoietic stem cells. Cell. Mol. Life Sci. 2010, 67, 1713–1722.
- List of publications using AZD 7762 hydrochloride (Axon 1399) purchased from Axon Medchem
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1357 | SD 169 |
From $66.00 |
| 1358 | BIRB 796 |
From $71.50 |
| 1363 | SB 203580 |
From $104.50 |
| 1364 | SB 202190 |
From $104.50 |
| 1365 | PD169316 |
From $104.50 |
| 1379 | PF 477736 |
From $77.00 |
| 1494 | MK 1775 |
From $88.00 |
| 1636 | CHIR124 |
From $66.00 |
| 2390 | HAMNO |
From $93.50 |
| 3828 | SCH900776 dihydrochloride |
From Inquiry |
| 3932 | CCT-245737 |
From Inquiry |
| 4145 | LY2606368 mesylate |
From Inquiry |
| 4264 | ART-446 |
From Inquiry |
