SCH900776 dihydrochloride
- MK-8776 dihydrochloride
Axon 3828
CAS:
891494-63-6
- Optical Purity: 99% e.e.
- Soluble in water and DMSO
- MF: C13H18BrN7.2HCl
- MW: 449.18
Description
SCH900776 is a potent, selective and orally bioavailable inhibitor of CHK1 (IC50 = 3 nM), highly selective against CHK2 (IC50 = 1500 nM) and CDK2 (IC50 = 160 nM).
More Information
| Parent CAS No. | 891494-63-6 |
|---|---|
| Chemical Name | (R)-6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine dihydrochloride |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1([C@@H]2CCCNC2)=NC2=C(C3=CN(C)N=C3)C=NN2C(N)=C1Br.Cl.Cl |&1:1,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C15H18BrN7/c1-22-8-10(6-19-22)11-7-20-23-14(17)12(16)13(21-15(11)23)9-3-2-4-18-5-9/h6-9,18H,2-5,17H2,1H3/t9-/m1/s1 |
| InChiKey | GMIZZEXBPRLVIV-SECBINFHSA-N |
| CID | 46239015 |
| Short Description | CHK1 Inhibitor |
References
- TJ Guzi et al. Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening. Mol Cancer Ther. 2011 Apr;10(4):591-602.
- M Labroli et al. Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: a template-based approach--part 2. Bioorg Med Chem Lett. 2011 Jan 1;21(1):471-4.
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