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ART-446

Axon 4264
CAS:  2984543-29-3
  • Optical Purity:  98% e.e.
  • Soluble in 0.1N HCl(aq) and DMSO
  • MF:  C20H19F5N8O
  • MW:  482.41

Description

ART-446 is a potent small molecule CHK2 (Checkpoint kinase 2) inhibitor (IC 50 = 9 nM). It exhibits promising potential in enhancing the therapeutic effects of Olaparib (Axon 1464) and Irinotecan (Axon 3370).

More Information

Parent CAS No. 2984543-29-3
Chemical Name 3-Amino-6-(5-fluoro-2-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)pyridin-4-yl)-N-((3S,5S)-5-fluoropiperidin-3-yl)pyrazine-2-carboxamide
extra_info Sold in collaboration with Chemietek
SMILES N1C=C(F)C(C2N=C(C(=O)N[C@H]3C[C@H](F)CNC3)C(N)=NC=2)=CC=1C1C=NN(CC(F)(F)F)C=1 |&1:11,13,r|
MFCD N.A.
InChi N.A.
InChiKey N.A.
CID N.A.
Short Description CHK2 inhibitor

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