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Gefitinib
- ZD 1839 - Iressa
- Soluble in DMSO
- MF: C22H24ClFN4O3
- MW: 446.9
Description
Gefitinib is a selective, ATP-competitive epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that reduces receptor autophosphorylation and downstream MAPK and PI3K–AKT signaling.
Gefitinib is a first-generation EGFR inhibitor used extensively to study EGFR-dependent growth and oncogenic signaling. It is particularly relevant to models bearing activating EGFR mutations and to mechanisms of acquired resistance such as T790M.
Key Features
- Selective first-generation EGFR tyrosine kinase inhibitor
- Blocks EGFR autophosphorylation
- Suppresses MAPK and PI3K–AKT pathway output
- Reference compound for EGFR mutation and resistance studies
Applications
- EGFR kinase and phosphorylation assays
- EGFR-mutant lung cancer models
- Growth-factor signaling research
- Acquired resistance and combination-treatment studies
More Information
| Parent CAS No. | 184475-35-2 |
|---|---|
| Chemical Name | N-(3-chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine |
| SMILES | C1CN(CCCOC2C(OC)=CC3=NC=NC(NC4C=C(Cl)C(F)=CC=4)=C3C=2)CCO1 |
| MFCD | MFCD04307832 |
| InChi | InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27) |
| InChiKey | XGALLCVXEZPNRQ-UHFFFAOYSA-N |
| CID | 123631 |
| Short Description | EGFR inhibitor |
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