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CP 547632
- Soluble in DMSO
- MF: C20H24BrF2N5O3S
- MW: 532.4
Description
CP 547632 is a potent oral VEGFR2/KDR tyrosine kinase inhibitor that also targets basic FGF kinase activity, with IC50 values of 11 nM and 9 nM, respectively.
VEGFR2 and FGF signaling regulate endothelial proliferation, vascular permeability and angiogenic remodeling. CP 547632 is useful for studies of antiangiogenic kinase inhibition and VEGF-stimulated receptor autophosphorylation.
Key Features
- Potent inhibitor of VEGFR2/KDR signaling
- IC50: 11 nM for VEGFR2 and 9 nM for basic FGF kinase
- Inhibits VEGF-stimulated VEGFR2 autophosphorylation in cells
- Selective versus EGFR, PDGFRβ and related tyrosine kinases
Applications
- VEGF/VEGFR2 signaling research
- Angiogenesis assay development
- Endothelial kinase pathway studies
- Antiangiogenic oncology pharmacology
More Information
| Parent CAS No. | 252003-65-9 |
|---|---|
| Chemical Name | 3-(4-bromo-2,6-difluorobenzyloxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide |
| SMILES | C1(Br)C=C(F)C(COC2C(C(=O)N)=C(NC(=O)NCCCCN3CCCC3)SN=2)=C(F)C=1 |
| MFCD | MFCD07772279 |
| InChi | InChI=1S/C20H24BrF2N5O3S/c21-12-9-14(22)13(15(23)10-12)11-31-18-16(17(24)29)19(32-27-18)26-20(30)25-5-1-2-6-28-7-3-4-8-28/h9-10H,1-8,11H2,(H2,24,29)(H2,25,26,30) |
| InChiKey | HXHAJRMTJXHJJZ-UHFFFAOYSA-N |
| CID | 9811611 |
| Short Description | VEGFR2 inhibitor |
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