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OSI 930
- Soluble in DMSO
- MF: C22H16F3N3O2S
- MW: 443.44
Description
OSI 930 is an orally active receptor tyrosine kinase inhibitor targeting c-KIT and VEGFR2/KDR signaling.
c-KIT can drive tumor cell proliferation, while VEGFR2 mediates angiogenic endothelial signaling. OSI 930 is useful for studying combined effects on tumor-cell intrinsic RTK signaling and tumor-associated vascular growth pathways.
Key Features
- Orally active c-KIT and VEGFR2 inhibitor
- Targets tumor proliferation and angiogenic signaling pathways
- Useful for receptor tyrosine kinase selectivity studies
- Relevant to oncology models involving KIT or VEGF signaling
Applications
- c-KIT and VEGFR2 kinase assays
- Angiogenesis research
- Cancer cell proliferation studies
- RTK-driven tumor model profiling
More Information
| Parent CAS No. | 728033-96-3 |
|---|---|
| Chemical Name | 3-(quinolin-4-ylmethylamino)-N-(4-(trifluoromethoxy)phenyl)thiophene-2-carboxamide |
| SMILES | C1C=C2C(CNC3C=CSC=3C(NC3C=CC(OC(F)(F)F)=CC=3)=O)=CC=NC2=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C22H16F3N3O2S/c23-22(24,25)30-16-7-5-15(6-8-16)28-21(29)20-19(10-12-31-20)27-13-14-9-11-26-18-4-2-1-3-17(14)18/h1-12,27H,13H2,(H,28,29) |
| InChiKey | FGTCROZDHDSNIO-UHFFFAOYSA-N |
| CID | 9868037 |
| Short Description | Kit/VEGFR 2 inhibitor |
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