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Sunitinib malate
- SU 11248 - Sutent
- Parent CAS: 557795-19-4
- Soluble in DMSO
- MF: C22H27FN4O2.C5H8O4
- MW: 530.59
Description
Sunitinib malate is an orally active multitarget receptor tyrosine kinase inhibitor that inhibits VEGFRs, PDGFRs, KIT, FLT3 and related growth-factor receptors.
Sunitinib blocks tumor angiogenesis and receptor-driven proliferation through combined inhibition of vascular and oncogenic kinase signaling. It is a widely used reference for anti-angiogenic multikinase pharmacology and resistance studies.
Key Features
- Multitarget VEGFR/PDGFR/KIT kinase inhibitor
- Blocks angiogenic and proliferative signaling
- Orally active antineoplastic pharmacology
- Useful for receptor-kinase selectivity and resistance research
Applications
- VEGFR and PDGFR kinase assays
- Angiogenesis and endothelial-cell models
- KIT- and FLT3-dependent cancer research
- Multikinase inhibitor resistance studies
More Information
| Parent CAS No. | 557795-19-4 |
|---|---|
| Chemical Name | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidine)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide malate |
| extra_info | . |
| MFCD | MFCD08282795 |
| Short Description | PDGFR inhibitor |
References
- J Motzer et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007, 356(2), 115–124.
- ED Deeks and GM Keating. Sunitinib. Drugs 2006, 66, 2255-2266.
- TJ Abrams et al. SU11248 Inhibits KIT and Platelet-derived Growth Factor Receptor β in Preclinical Models of Human Small Cell Lung Cancer. Mol. Cancer Ther. 2003, 2, 471-478.
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