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PF 04217903 mesylate
- Parent CAS: 956905-27-4
- Soluble in 0.1N HCl(aq)
- MF: C19H16N8O.CH4O3S
- MW: 468.49
Description
PF 04217903 mesylate is an orally bioavailable, selective MET/c-MET tyrosine kinase inhibitor with low-nanomolar binding potency.
Selective MET blockade enables analysis of HGF/MET pathway dependence without broad multi-kinase effects. PF 04217903 is useful in cancer models that evaluate MET-driven proliferation, survival, motility and resistance signaling.
Key Features
- Selective MET/c-MET kinase inhibitor
- Orally bioavailable small-molecule tool
- Low-nanomolar MET binding potency reported
- Useful for isolating MET-dependent signaling effects
Applications
- MET kinase inhibitor assays
- HGF/MET pathway research
- Cancer cell proliferation and migration studies
- RTK selectivity and resistance models
More Information
| Parent CAS No. | 956905-27-4 |
|---|---|
| Chemical Name | 2-(4-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol methanesulfonate |
| SMILES | C1(C2C=NN(CCO)C=2)N=C2N(CC3C=CC4N=CC=CC=4C=3)N=NC2=NC=1.O=S(=O)(O)C |
| MFCD | MFCD17392584 |
| InChi | InChI=1S/C19H16N8O.CH4O3S/c28-7-6-26-12-15(9-22-26)17-10-21-18-19(23-17)27(25-24-18)11-13-3-4-16-14(8-13)2-1-5-20-16;1-5(2,3)4/h1-5,8-10,12,28H,6-7,11H2;1H3,(H,2,3,4) |
| InChiKey | HBEMHKVWZJTVOC-UHFFFAOYSA-N |
| CID | 24852079 |
| Short Description | c-MET inhibitor |
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