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Regorafenib
- BAY 73-4506 - Stivarga
- Soluble in DMSO
- MF: C21H15ClF4N4O3
- MW: 482.82
Description
Regorafenib is an oral multi-kinase inhibitor targeting angiogenic, stromal and oncogenic kinases including VEGFR, TIE2, KIT and RAF family signaling.
Regorafenib is pharmacologically relevant for studying tumor angiogenesis, stromal signaling and broad kinase network suppression. Its VEGFR2/TIE2 activity supports investigation of antiangiogenic mechanisms in cancer models.
Key Features
- Oral multi-kinase inhibitor
- Targets VEGFR/TIE2 angiogenic signaling
- Also modulates KIT and RAF-driven oncogenic pathways
- Reference compound for broad-spectrum anticancer kinase inhibition
Applications
- Angiogenesis and endothelial signaling studies
- Oncology kinase pathway research
- Tumor-stroma interaction models
- Kinase selectivity and resistance assays
More Information
| Parent CAS No. | 755037-03-7 |
|---|---|
| Chemical Name | 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide |
| SMILES | C1(Cl)C=CC(NC(=O)NC2C=CC(OC3C=C(C(=O)NC)N=CC=3)=CC=2F)=CC=1C(F)(F)F |
| MFCD | MFCD16038047 |
| InChi | InChI=1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32) |
| InChiKey | FNHKPVJBJVTLMP-UHFFFAOYSA-N |
| CID | 11167602 |
| Short Description | RTK inhibitor |
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