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AMG 706
- Motesanib diphosphate
- Parent CAS: 453562-69-1
- Soluble in water
- MF: C22H23N5O.2H3O4P
- MW: 569.44
Description
More Information
| Parent CAS No. | 453562-69-1 |
|---|---|
| Chemical Name | N-(3,3-dimethylindolin-6-yl)-2-(pyridin-4-ylmethylamino)nicotinamide bis(phosphate) |
| SMILES | C1(NCC2C=CN=CC=2)=NC=CC=C1C(NC1=CC2=C(C=C1)C(C)(C)CN2)=O.P(O)(O)(=O)O.P(O)(O)(=O)O |
| MFCD | MFCD12407403 |
| InChi | InChI=1S/C22H23N5O.2H3O4P/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15;2*1-5(2,3)4/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28);2*(H3,1,2,3,4) |
| InChiKey | ONDPWWDPQDCQNJ-UHFFFAOYSA-N |
| CID | 16097729 |
| Short Description | VEGFR inhibitor |
References
- A Polverino et al. AMG 706, an Oral, Multikinase Inhibitor that Selectively Targets Vascular Endothelial Growth Factor, Platelet-Derived Growth Factor, and Kit Receptors, Potently Inhibits Angiogenesis (...). Cancer Res. 2006, 66, 8715.
- A Coxon et al. Broad Antitumor Activity in Breast Cancer Xenografts by Motesanib, a Highly Selective, Oral Inhibitor of Vascular Endothelial Growth Factor, Platelet-Derived Growth Factor, and Kit Receptors. Clin. Cancer Res. 2009, 15, 110.
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