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AMG 208
- Moderately soluble in DMSO with 0.1N HCl(aq)
- MF: C22H17N5O2
- MW: 383.4
Description
More Information
| Parent CAS No. | 1002304-34-8 |
|---|---|
| Chemical Name | 7-methoxy-4-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methylphenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)quinoline |
| SMILES | N1C2C(=CC=C(OC)C=2)C(OCC2N3C(=NN=2)C=CC(C2=CC=CC=C2)=N3)=CC=1 |
| MFCD | MFCD17215205 |
| InChi | InChI=1S/C22H17N5O2/c1-28-16-7-8-17-19(13-16)23-12-11-20(17)29-14-22-25-24-21-10-9-18(26-27(21)22)15-5-3-2-4-6-15/h2-13H,14H2,1H3 |
| InChiKey | HEAIZQNMNCHNFD-UHFFFAOYSA-N |
| CID | 24864821 |
| Short Description | MET inhibitor |
References
- B.K. Albrecht et al. Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase. J. Med. Chem. 2008, 51, 2879-2882.
- A.A. Boezio et al. Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors. Bioorg. Med. Chem. Lett. 2009, 19, 6307-6312.
- X. Liu et al. Developing c-MET pathway inhibitors for cancer therapy: progress and challenges. Trends Mol. Med. 2010, 16, 37-45.
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