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Quizartinib dihydrochloride
- AC220 dihydrochloride
- Parent CAS: 950769-58-1
- Soluble in DMSO
- MF: C29H32N6O4S.2HCl
- MW: 633.59
Description
Quizartinib dihydrochloride is a highly potent and selective FLT3 tyrosine kinase inhibitor with low-nanomolar activity in biochemical and cellular assays.
FLT3 signaling is a major driver in subsets of acute myeloid leukemia. Quizartinib is a second-generation FLT3 inhibitor used to investigate FLT3-dependent proliferation, kinase selectivity and resistance mechanisms in AML models.
Key Features
- Potent second-generation FLT3 inhibitor
- Low-nanomolar biochemical and cellular activity
- Focused selectivity profile across the human kinome
- Relevant to FLT3-driven AML research
Applications
- FLT3 kinase assay development
- Acute myeloid leukemia models
- Kinase selectivity and resistance studies
- Targeted oncology pharmacology
More Information
| Parent CAS No. | 950769-58-1 |
|---|---|
| Chemical Name | 1-(5-tert-Butyl-isoxazol-3-yl)-3-{4-[7-(2-morpholin-4-yl-ethoxy)-benzo[d]imidazo[2,1-b]thiazol-2-yl]-phenyl}-urea dihydrochloride |
| SMILES | N(C1C=C(C(C)(C)C)ON=1)C(NC1=CC=C(C2=CN3C4=CC=C(OCCN5CCOCC5)C=C4SC3=N2)C=C1)=O.Cl.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C29H32N6O4S.2ClH/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34;;/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36);2*1H |
| InChiKey | DHYPGRVMIOATAE-UHFFFAOYSA-N |
| CID | 25184035 |
| Short Description | FLT3 inhibitor |
References
- PP Zarrinkar et al. AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). Blood 2009, 114 (14), 2984-2992.
- PH Wiernik. FLT3 inhibitors for the treatment of acute myeloid leukemia. Clin. Adv. Hematol. Oncol. 2010, 8(6), 429-444.
- Q Chao et al. Identification of N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea dihydrochloride (AC220), a uniquely potent, selective, and (...). J. Med. Chem. 2009, 52(23), 7808-7816.
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