EGFR

The epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein that constitutes one of four members of the erbB family of tyrosine kinase receptors. The ErbB receptor tyrosine kinase family (RTK class I) consists of ErbB1/EGFR/HER1, and ErbB2-4/HER2-4[1]. Binding of EGFR to its cognate ligands leads to autophosphorylation of receptor tyrosine kinase and subsequent activation of signal transduction pathways that are involved in regulating cellular proliferation, differentiation, and survival. Interestingly, ERbB receptor tyrosine kinases have important roles in human cancer. The gene symbol, ErbB, is derived from the name of a viral oncogene to which these receptors are homologous: Erythroblastic Leukemia Viral Oncogene. Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's disease.[2] Additionally, research revealed that the expression or activation of epidermal growth factor receptor and ErbB2 are altered in many epithelial tumors, and clinical studies indicate that they have important roles in tumor aetiology and progression[3].


[1] Regulation of ERBB Receptors.C.S. Gerbin.Nature Education 2010, 3(9), 36.
[2] The EGF receptor family: spearheading a merger of signaling and therapeutics. E.M. Bublil, Y. Yarden. Curr. Opin. Cell Biol. 2007, 19 (2), 124–134.
[3] ERBB receptors and cancer: the complexity of targeted inhibitors. N.E.Hynes,H.A. Lane. Nat Rev Cancer. 2005, 5(5),341.

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Axon ID Name Description From price
1653 AEE 788 EGFR, ErbB2 and VEGFR tyrosine kinase inhibitor €95.00
1986 AST 1306 tosylate ErbB2 and EGFR inhibitor €105.00
2563 AZD 3759 Potent, orally active, brain-penetrant, EGFR tyrosine kinase inhibitor €85.00
2342 AZD 9291 Potent oral, irreversible, third-generation EGFR TKI with selectivity for mutant EGFRs €95.00
1544 BIBW 2992 EGFR and ErbB-2/HER2 tyrosine kinase inhibitor €65.00
1433 CI 1033 EGFR tyrosine kinase inhibitor €60.00
2680 EAI045 Allosteric EGFR inhibitor (L858R/T790M-specific)  Recently added €105.00
1760 EGFR Inhibitor [879127-07-8] Highly selective EGFR tyrosine kinase inhibitor €125.00
1128 Erlotinib hydrochloride EGFR tyrosine kinase inhibitor €70.00
1393 Gefitinib EGFR tyrosine kinase inhibitor €70.00
1395 Lapatinib ditosylate EGFR and ErbB-2/HER2 tyrosine kinase inhibitor €95.00
1526 Neratinib EGFR and ErbB-2/HER2 tyrosine kinase inhibitor €90.00
1632 OSI 420 EGFR tyrosine kinase inhibitor €95.00
1665 Pelitinib EGFR tyrosine kinase inhibitor €95.00
1411 Vandetanib VEGFR and EGFR tyrosine kinase inhibitor €55.00

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