The ErbB receptor tyrosine kinase family (RTK class I) consists of four cell surface receptors: ErbB1/EGFR/HER1, and ErbB2-4/HER2-4[1]. ERbB receptor tyrosine kinases have important roles in human cancer. The gene symbol, ErbB, is derived from the name of a viral oncogene to which these receptors are homologous: Erythroblastic Leukemia Viral Oncogene. Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's disease.[2] Additionally, research revealed that the expression or activation of epidermal growth factor receptor and ErbB2 are altered in many epithelial tumors, and clinical studies indicate that they have important roles in tumor aetiology and progression[3].

[1] Regulation of ERBB Receptors.C.S. Gerbin.Nature Education 2010, 3(9), 36.
[2] The EGF receptor family: spearheading a merger of signaling and therapeutics. E.M. Bublil, Y. Yarden. Curr. Opin. Cell Biol. 2007, 19 (2), 124–134.
[3] ERBB receptors and cancer: the complexity of targeted inhibitors. N.E.Hynes,H.A. Lane. Nat Rev Cancer. 2005, 5(5),341.

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Axon ID Name Description From price
1653 AEE 788 EGFR, ErbB2 and VEGFR tyrosine kinase inhibitor €80.00
1986 AST 1306 tosylate ErbB2 and EGFR inhibitor €90.00
1544 BIBW 2992 EGFR and ErbB-2/HER2 tyrosine kinase inhibitor €50.00
3853 BMS-599626 Potent and selective EGFR and ErbB2 inhibitor Inquire
1537 CP 724714 ErbB-2/HER2 kinase inhibitor €80.00
3235 Dacomitinib Potent irreversible pan-HER inhibitor €60.00
1395 Lapatinib ditosylate EGFR and ErbB-2/HER2 tyrosine kinase inhibitor €80.00
1526 Neratinib EGFR and ErbB-2/HER2 tyrosine kinase inhibitor €80.00
2920 Poziotinib Irreversible pan-HER inhibitor €95.00
2053 TAK 165 ErbB2/HER2 kinase inhibitor €60.00
3232 TAK-788 Potent and selective EGFR and ErbB-2/HER2 tyrosine kinase inhibitor €70.00

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