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Dacomitinib
- PF-00299804
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C24H25ClFN5O2
- MW: 469.94
Description
More Information
| Parent CAS No. | 1110813-31-4 |
|---|---|
| Chemical Name | (E)-N-(4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enamide |
| SMILES | C1CCN(C/C=C/C(NC2=CC3C(NC4C=CC(F)=C(Cl)C=4)=NC=NC=3C=C2OC)=O)CC1 |
| MFCD | N.A. |
| InChi | InChI=1S/C24H25ClFN5O2/c1-33-22-14-20-17(24(28-15-27-20)29-16-7-8-19(26)18(25)12-16)13-21(22)30-23(32)6-5-11-31-9-3-2-4-10-31/h5-8,12-15H,2-4,9-11H2,1H3,(H,30,32)(H,27,28,29)/b6-5+ |
| InChiKey | LVXJQMNHJWSHET-AATRIKPKSA-N |
| CID | 11511120 |
| Short Description | HER inhibitor |
References
- JA Engelman et al. PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib. Cancer Res. 2007 Dec 15;67(24):11924-32.
- JB Smaill. Tyrosine Kinase Inhibitors. 20. Optimization of Substituted Quinazoline and Pyrido[3,4-d]pyrimidine Derivatives as Orally Active, Irreversible Inhibitors of the Epidermal Growth Factor Receptor Family. J Med Chem. 2016 Sep 8;59(17):8103-24.
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