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CP 724714
- Soluble in DMSO
- MF: C27H27N5O3
- MW: 469.53
Description
CP 724714 is an orally active, selective HER2/ErbB2 tyrosine kinase inhibitor designed to block HER2-driven signaling.
HER2 kinase activation promotes proliferation and survival in HER2-amplified tumor models. CP 724714 is useful for studying ErbB2 pathway dependence, HER2-selective pharmacology and inhibitor responses in cancer cell systems.
Key Features
- Selective HER2/ErbB2 kinase inhibitor
- Orally active compound for oncology pharmacology studies
- Suppresses HER2-driven cellular signaling
- Useful for evaluating HER2 pathway dependence
Applications
- HER2 signaling research
- Breast cancer cell model studies
- ErbB kinase inhibitor assays
- Antiproliferative pharmacology profiling
More Information
| Parent CAS No. | 383432-38-0 |
|---|---|
| Chemical Name | 2-Methoxy-N-((E)-3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-acetamide |
| SMILES | C1(/C=C/CNC(COC)=O)C=C2C(NC3C=C(C)C(OC4C=CC(C)=NC=4)=CC=3)=NC=NC2=CC=1 |
| MFCD | MFCD15144738 |
| InChi | InChI=1S/C27H27N5O3/c1-18-13-21(8-11-25(18)35-22-9-6-19(2)29-15-22)32-27-23-14-20(7-10-24(23)30-17-31-27)5-4-12-28-26(33)16-34-3/h4-11,13-15,17H,12,16H2,1-3H3,(H,28,33)(H,30,31,32)/b5-4+ |
| InChiKey | LLVZBTWPGQVVLW-SNAWJCMRSA-N |
| CID | 9874913 |
| Short Description | ErbB 2 inhibitor |
References
- JP Jani et al. Discovery and Pharmacologic Characterization of CP-724,714, a Selective ErbB2 Tyrosine Kinase Inhibitor. Cancer Res. 2007, 67(20), 9887-9893.
- PN Munster et al. First Study of the Safety, Tolerability, and Pharmacokinetics of CP-724,714 in Patients with Advanced Malignant Solid HER2-Expressing Tumors. Clin. Cancer Res. 2007, 13, 1238-1245.
- F Guo et al. Pharmacokinetics of a HER2 tyrosine kinase inhibitor CP-724,714 in patients with advanced malignant HER2 positive solid tumors: correlations with clinical characteristics and safety. Cancer Chemother. Pharmacol. 2008, 62(1), 97-109.
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